The response of smoke detectors to pyrolysis and combustion products from aircraft interior materials

The following projects were completed as part of the effort to develop and test economically feasible fire-resistant materials for interior furnishings of aircraft as well as detectors of incipient fires in passenger and cargo compartments: (1) determination of the sensitivity of various contemporary gas and smoke detectors to pyrolysis and combustion products from materials commonly used in aircraft interiors and from materials that may be used in the future, (2) assessment of the environmental limitations to detector sensitivity and reliability. The tests were conducted on three groups of materials by exposure to the following three sources of exposure: radiant and Meeker burner flame, heated coil, and radiant source only. The first test series used radiant heat and flame exposures on easily obtainable test materials. Next, four materials were selected from the first group and exposed to an incandescent coil to provide the conditions for smoldering combustion. Finally, radiant heat exposures were used on advanced materials that are not readily available

The GPRIME approach to finite element modeling

GPRIME, an interactive modeling system, runs on the CDC 6000 computers and the DEC VAX 11/780 minicomputer. This system includes three components: (1) GPRIME, a user friendly geometric language and a processor to translate that language into geometric entities, (2) GGEN, an interactive data generator for 2-D models; and (3) SOLIDGEN, a 3-D solid modeling program. Each component has a computer user interface of an extensive command set. All of these programs make use of a comprehensive B-spline mathematics subroutine library, which can be used for a wide variety of interpolation problems and other geometric calculations. Many other user aids, such as automatic saving of the geometric and finite element data bases and hidden line removal, are available. This interactive finite element modeling capability can produce a complete finite element model, producing an output file of grid and element data

Squeeze-Film Flow in the Presence of a Thin Porous Bed, with Application to the Human Knee Joint

Motivated by the desire for a better understanding of the lubrication of the human knee joint, the squeeze-film flow of a thin layer of Newtonian fluid (representing the synovial fluid) filling the gap between a flat impermeable surface (representing the femoral condyles) and a flat thin porous bed (representing the articular cartilage) coating a stationary flat impermeable surface (representing the tibial plateau) is considered. As the impermeable surface approaches the porous bed under a prescribed constant load all of the fluid is squeezed out of the gap in a finite contact time. In the context of the knee, the size of this contact time suggests that when a person stands still for a short period of time their knees may be fluid lubricated, but that when they stand still for a longer period of time contact between the cartilage-coated surfaces may occur. The fluid particle paths are calculated, and the penetration depths of fluid particles into the porous bed are determined. In the context of the knee, these penetration depths provide a measure of how far into the cartilage nutrients are carried by the synovial fluid, and suggest that when a person stands still nutrients initially in the fluid layer penetrate only a relatively small distance into the cartilage. However, the model also suggests that the cumulative effect of repeated loading and unloading of the knees during physical activity such as walking or running may be sufficient to carry nutrients deep into the cartilage

Similarities and contrasts in tectonic and volcanic style and history along the Colorado plateaus-to-basin and range transition zone in Western Arizona: Geologic framework for tertiary extensional tectonics

The overall temporal and spatial relations between middle Tertiary volcanism and tectonism from the Basin and Range province onto the edge of the Colorado Plateaus province suggest that a single magnetic-tectonic episode affected the entire region more or less simultaneously during this period. The episode followed a post-Laramide (late Eocene through Oligocene) period of 25 million years of relative stability. Middle Tertiary volcanism did not migrate gradually eastward in a simple fashion onto the Colorado Plateau. In fact, late Oligocene volcanism appears to be more voluminous near the Aquarius Mountains than throughout the adjacent Basin and Range province westward to the Colorado River. Any model proposed to explain the cause of extension and detachment faulting in the eastern part of the Basin and Range province must consider that the onset of volcanism appears to have been approximately synchronous from the Colorado River region of the Basin and Range across the transition zone and onto the edge of the Colorado Plateaus

Molecular Line Emission from Massive Protostellar Disks: Predictions for ALMA and the EVLA

We compute the molecular line emission of massive protostellar disks by solving the equation of radiative transfer through the cores and disks produced by the recent radiation-hydrodynamic simulations of Krumholz, Klein, & McKee. We find that in several representative lines the disks show brightness temperatures of hundreds of Kelvin over velocity channels ~10 km s^-1 wide, extending over regions hundreds of AU in size. We process the computed intensities to model the performance of next-generation radio and submillimeter telescopes. Our calculations show that observations using facilities such as the EVLA and ALMA should be able to detect massive protostellar disks and measure their rotation curves, at least in the nearest massive star-forming regions. They should also detect significant sub-structure and non-axisymmetry in the disks, and in some cases may be able to detect star-disk velocity offsets of a few km s^-1, both of which are the result of strong gravitational instability in massive disks. We use our simulations to explore the strengths and weaknesses of different observational techniques, and we also discuss how observations of massive protostellar disks may be used to distinguish between alternative models of massive star formation.Comment: 15 pages, 9 figures, emulateapj format, accepted for publication in ApJ. Resolution of figures severely degraded to fit within size limits. Download the full paper from http://www.astro.princeton.edu/~krumholz/recent.htm

An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule

HIV-1 integrase (IN) is a validated target for developing antiretroviral inhibitors. Using affinity acetylation and mass spectrometric (MS) analysis, we previously identified a tetra-acetylated inhibitor (2E)-3-[3,4-bis(acetoxy)phenyl]-2-propenoate-N-[(2E)-3-[3,4-bis(acetyloxy)phenyl]-1-oxo-2-propenyl]-L-serine methyl ester; compound 1] that selectively modified Lys173 at the IN dimer interface. Here we extend our efforts to dissect the mechanism of inhibition and structural features that are important for the selective binding of compound 1. Using a subunit exchange assay, we found that the inhibitor strongly modulates dynamic interactions between IN subunits. Restricting such interactions does not directly interfere with IN binding to DNA substrates or cellular cofactor lens epithelium-derived growth factor, but it compromises the formation of the fully functional nucleoprotein complex. Studies comparing compound 1 with a structurally related IN inhibitor, the tetra-acetylated-chicoric acid derivative (2R,3R)-2,3-bis[[(2E)-3-[3,4-bis(acetyloxy)phenyl]-1-oxo-2-propen-1-yl]oxy]-butanedioic acid (compound 2), indicated striking mechanistic differences between these agents. The structures of the two inhibitors differ only in their central linker regions, with compounds 1 and 2 containing a single methyl ester group and two carboxylic acids, respectively. MS experiments highlighted the importance of these structural differences for selective binding of compound 1 to the IN dimer interface. Moreover, molecular modeling of compound 1 complexed to IN identified a potential inhibitor binding cavity and provided structural clues regarding a possible role of the central methyl ester group in establishing an extensive hydrogen bonding network with both interacting subunits. The proposed mechanism of action and binding site for the small-molecule inhibitor identified in the present study provide an attractive venue for developing allosteric inhibitors of HIV-1 IN

Straggler Root-Cause and Impact Analysis for Massive-scale Virtualized Cloud Datacenters

Increased complexity and scale of virtualized distributed systems has resulted in the manifestation of emergent phenomena substantially affecting overall system performance. This phenomena is known as “Long Tail”, whereby a small proportion of task stragglers significantly impede job completion time. While work focuses on straggler detection and mitigation, there is limited work that empirically studies straggler root-cause and quantifies its impact upon system operation. Such analysis is critical to ascertain in-depth knowledge of straggler occurrence for focusing developmental and research efforts towards solving the Long Tail challenge. This paper provides an empirical analysis of straggler root-cause within virtualized Cloud datacenters; we analyze two large-scale production systems to quantify the frequency and impact stragglers impose, and propose a method for conducting root-cause analysis. Results demonstrate approximately 5% of task stragglers impact 50% of total jobs for batch processes, and 53% of stragglers occur due to high server resource utilization. We leverage these findings to propose a method for extreme straggler detection through a combination of offline execution patterns modeling and online analytic agents to monitor tasks at runtime. Experiments show the approach is capable of detecting stragglers less than 11% into their execution lifecycle with 95% accuracy for short duration jobs