Impaired limb shortening following stroke: what's in a name?

BackgroundDifficulty advancing the paretic limb during the swing phase of gait is a prominent manifestation of walking dysfunction following stroke. This clinically observable sign, frequently referred to as 'foot drop', ostensibly results from dorsiflexor weakness.ObjectiveHere we investigated the extent to which hip, knee, and ankle motions contribute to impaired paretic limb advancement. We hypothesized that neither: 1) minimal toe clearance and maximal limb shortening during swing nor, 2) the pattern of multiple joint contributions to toe clearance and limb shortening would differ between post-stroke and non-disabled control groups.MethodsWe studied 16 individuals post-stroke during overground walking at self-selected speed and nine non-disabled controls who walked at matched speeds using 3D motion analysis.ResultsNo differences were detected with respect to the ankle dorsiflexion contribution to toe clearance post-stroke. Rather, hip flexion had a greater relative influence, while the knee flexion influence on producing toe clearance was reduced.ConclusionsSimilarity in the ankle dorsiflexion, but differences in the hip and knee, contributions to toe clearance between groups argues strongly against dorsiflexion dysfunction as the fundamental impairment of limb advancement post-stroke. Marked reversal in the roles of hip and knee flexion indicates disruption of inter-joint coordination, which most likely results from impairment of the dynamic contribution to knee flexion by the gastrocnemius muscle in preparation for swing. These findings suggest the need to reconsider the notion of foot drop in persons post-stroke. Redirecting the focus of rehabilitation and restoration of hemiparetic walking dysfunction appropriately, towards contributory neuromechanical impairments, will improve outcomes and reduce disability

Optical excitation of nonlinear spin waves

We demonstrate a technique for exciting spin waves in an ultracold gas of Rb-87 atoms based on tunable AC Stark potentials. This technique allows us to excite normal modes of spin waves with arbitrary amplitudes in the trapped gas, including dipole, quadrupole, octupole, and hexadecapole modes. These modes exhibit strong nonlinearities, which manifest as amplitude dependence of the excitation frequencies and departure from sinusoidal behavior. Our results are in good agreement with a full treatment of a quantum Boltzmann transport equation.Comment: 11 pages, 5 figure

Holographic gauge mediation via strongly coupled messengers

We consider a relative of semi-direct gauge mediation where the hidden sector exists at large 't Hooft coupling. Such scenarios can be difficult to describe using perturbative field theory methods but may fall into the class of holographic gauge mediation scenarios, meaning that they are amenable to the techniques of gauge/gravity duality. We use a recently found gravity solution to examine one such case where the hidden sector is a cascading gauge theory resulting in a confinement scale not much smaller than the messenger mass. In the original construction of holographic gauge mediation, as in other examples of semi-direct gauge mediation at strong coupling, the primary contributions to visible sector soft terms come from weakly coupled messenger mesons. In contrast to these examples, we describe the dual of a gauge theory where there are significant contributions from scales where the strongly coupled messenger quarks are the effective degrees of freedom. In this regime, the visible sector gaugino mass can be calculated entirely from holography.Comment: 42 pages, 3 figures, references added, typos and minor errors correcete

Decoherence-driven Cooling of a Degenerate Spinor Bose Gas

We investigate the relationship between the coherence of a partially Bose-condensed spinor gas and its temperature. We observe cooling of the normal component driven by decoherence as well the effect of temperature on decoherence rates.Comment: 4 pages, 2 figure

The Mystery of the Ramsey Fringe that Didn't Chirp

We use precision microwave spectroscopy of magnetically trapped, ultra-cold 87Rb to characterize intra- and inter-state density correlations. The cold collision shifts for both normal and condensed clouds are measured. The results verify the presence of the sometimes controversial "factors of two", in normal-cloud mean-field energies, both within a particular state and between two distinct spin species. One might expect that as two spin species decohere, the inter-state factor of two would revert to unity, but the associated frequency chirp one naively expects from such a trend is not observed in our data.Comment: Proceedings of the 18th International Conference on Atomic Physics (ICAP 2002

Thermally Induced Losses in Ultra-Cold Atoms Magnetically Trapped Near Room-Temperature Surfaces

We have measured magnetic trap lifetimes of ultra-cold Rb87 atoms at distances of 5-1000 microns from surfaces of conducting metals with varying resistivity. Good agreement is found with a theoretical model for losses arising from near-field magnetic thermal noise, confirming the complications associated with holding trapped atoms close to conducting surfaces. A dielectric surface (silicon) was found in contrast to be so benign that we are able to evaporatively cool atoms to a Bose-Einstein condensate by using the surface to selectively adsorb higher energy atoms.Comment: Improved theory curve eliminates discrepancy. JLTP in pres

Does inhibitory repetitive transcranial magnetic stimulation augment functional task practice to improve arm recovery in chronic stroke?

Introduction. Restoration of upper extremity (UE) functional use remains a challenge for individuals following stroke. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive modality that modulates cortical excitability and is being explored as a means to potentially ameliorate these deficits. The purpose of this study was to evaluate, in the presence of chronic stroke, the effects of low-frequency rTMS to the contralesional hemisphere as an adjuvant to functional task practice (FTP), to improve UE functional ability. Methods. Twenty-two individuals with chronic stroke and subsequent moderate UE deficits were randomized to receive 16 sessions (4 times/week for 4 weeks) of either real-rTMS or sham-rTMS followed by 1-hour of paretic UE FTP. Results. No differences in UE outcomes were revealed between the real-rTMS and sham-rTMS intervention groups. After adjusting for baseline differences, no differences were revealed in contralesional cortical excitability postintervention. In a secondary analysis, data pooled across both groups revealed small, but statistically significant, improvements in UE behavioral measures. Conclusions. rTMS did not augment changes in UE motor ability in this population of individuals with chronic stroke. The chronicity of our participant cohort and their degree of UE motor impairment may have contributed to inability to produce marked effects using rTMS

TLR2 and TLR4 in Ischemia Reperfusion Injury

Ischemia reperfusion (I/R) injury refers to the tissue damage which occurs when blood supply returns to tissue after a period of ischemia and is associated with trauma, stroke, myocardial infarction, and solid organ transplantation. Although the cause of this injury is multifactorial, increasing experimental evidence suggests an important role for the innate immune system in initiating the inflammatory cascade leading to detrimental/deleterious changes. The Toll-like Receptors (TLRs) play a central role in innate immunity recognising both pathogen- and damage-associated molecular patterns and have been implicated in a range of inflammatory and autoimmune diseases. In this paper, we summarise the current state of knowledge linking TLR2 and TLR4 to I/R injury, including recent studies which demonstrate that therapeutic inhibition of TLR2 has beneficial effects on I/R injury in a murine model of myocardial infarction