Ternary nucleation of H_2SO_4, NH_3 and H_2O

A classical theory of the ternary homogeneous nucleation of sulfuric acid—ammonia—water is presented. For NH3 mixing ratios exceeding 1 ppt, the presence of ammonia enhances the binary (sulfuric acid—water) nucleation rate by several orders of magnitude. However, the limiting component for ternary nucleation—as for binary nucleation—is sulfuric acid. The sulfuric acid concentration needed for significant ternary nucleation is several orders of magnitude below that required in binary case

Self-Sustaining Oscillations in Complex Networks of Excitable Elements

Random networks of symmetrically coupled, excitable elements can self-organize into coherently oscillating states if the networks contain loops (indeed loops are abundant in random networks) and if the initial conditions are sufficiently random. In the oscillating state, signals propagate in a single direction and one or a few network loops are selected as driving loops in which the excitation circulates periodically. We analyze the mechanism, describe the oscillating states, identify the pacemaker loops and explain key features of their distribution. This mechanism may play a role in epileptic seizures.Comment: 5 pages, 4 figures included, submitted to Phys. Rev. Let

Archaeological Investigations for the Canyon Hydroelectric Project, Comal County, Texas

During January 1986, the Center for Archaeological Research from The University of Texas at San Antonio conducted a pedestrian survey along portions of a proposed Canyon Lake hydroelectric transmission line right-of-way in Comal County, Texas, for the Guadalupe-Blanco River Authority. The survey located six prehistoric sites (41 CM 160, 41 CM 161, 41 CM 162, 41 CM 163, 41 CM 164, and 41 CM 166) in the right-of-way, and one historic building complex (41 CM 165) adjacent to but well outside of the right-of-way. Recommendations were made for further testing of the prehistoric sites and background research for the historic site to determine their potential eligibility for nomination to the National Register of Historic Places and as a Texas Archeological Landmark. During April 1986, the Center conducted testing at prehistoric sites 41 CM 160, 41 CM 161, 41 CM 162, 41 CM 163, and 41 CM 164. Archival research was done for 41 CM 165. This work was done for the Guadalupe-Blanco River Authority as required by the Texas Historical Commission. All of the prehistoric sites were found to be lithic quarry sites that are deemed to have little potential for contributing significant new archaeological information. None are recommended as potentially eligible for nomination to the National Register or for Texas Archeological Landmark status. The historic site (41 CM 165) appears to have National Register potential. Further background research, building documentation, and selective testing are recommended, but not as part of this project

Infection with a Virulent Strain of Wolbachia Disrupts Genome Wide-Patterns of Cytosine Methylation in the Mosquito Aedes aegypti

BACKGROUND Cytosine methylation is one of several reversible epigenetic modifications of DNA that allow a greater flexibility in the relationship between genotype and phenotype. Methylation in the simplest models dampens gene expression by modifying regions of DNA critical for transcription factor binding. The capacity to methylate DNA is variable in the insects due to diverse histories of gene loss and duplication of DNA methylases. Mosquitoes like Drosophila melanogaster possess only a single methylase, DNMT2. DESCRIPTION Here we characterise the methylome of the mosquito Aedes aegypti and examine its relationship to transcription and test the effects of infection with a virulent strain of the endosymbiont Wolbachia on the stability of methylation patterns. CONCLUSION We see that methylation in the A. aegypti genome is associated with reduced transcription and is most common in the promoters of genes relating to regulation of transcription and metabolism. Similar gene classes are also methylated in aphids and honeybees, suggesting either conservation or convergence of methylation patterns. In addition to this evidence of evolutionary stability, we also show that infection with the virulent wMelPop Wolbachia strain induces additional methylation and demethylation events in the genome. While most of these changes seem random with respect to gene function and have no detected effect on transcription, there does appear to be enrichment of genes associated with membrane function. Given that Wolbachia lives within a membrane-bound vacuole of host origin and retains a large number of genes for transporting host amino acids, inorganic ions and ATP despite a severely reduced genome, these changes might represent an evolved strategy for manipulating the host environments for its own gain. Testing for a direct link between these methylation changes and expression, however, will require study across a broader range of developmental stages and tissues with methods that detect splice variants.This research was supported by The National Health and Medical Research Council of Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Analysis of Nonlinear Synchronization Dynamics of Oscillator Networks by Laplacian Spectral Methods

We analyze the synchronization dynamics of phase oscillators far from the synchronization manifold, including the onset of synchronization on scale-free networks with low and high clustering coefficients. We use normal coordinates and corresponding time-averaged velocities derived from the Laplacian matrix, which reflects the network's topology. In terms of these coordinates, synchronization manifests itself as a contraction of the dynamics onto progressively lower-dimensional submanifolds of phase space spanned by Laplacian eigenvectors with lower eigenvalues. Differences between high and low clustering networks can be correlated with features of the Laplacian spectrum. For example, the inhibition of full synchoronization at high clustering is associated with a group of low-lying modes that fail to lock even at strong coupling, while the advanced partial synchronizationat low coupling noted elsewhere is associated with high-eigenvalue modes.Comment: Revised version: References added, introduction rewritten, additional minor changes for clarit

The Relative Importance of Innate Immune Priming in Wolbachia-Mediated Dengue Interference

The non-virulent Wolbachia strain wMel and the life-shortening strain wMelPop-CLA, both originally from Drosophila melanogaster, have been stably introduced into the mosquito vector of dengue fever, Aedes aegypti. Each of these Wolbachia strains interferes with viral pathogenicity and/or dissemination in both their natural Drosophila host and in their new mosquito host, and it has been suggested that this virus interference may be due to host immune priming by Wolbachia. In order to identify aspects of the mosquito immune response that might underpin virus interference, we used whole-genome microarrays to analyse the transcriptional response of A. aegypti to the wMel and wMelPop-CLA Wolbachia strains. While wMel affected the transcription of far fewer host genes than wMelPop-CLA, both strains activated the expression of some immune genes including anti-microbial peptides, Toll pathway genes and genes involved in melanization. Because the induction of these immune genes might be associated with the very recent introduction of Wolbachia into the mosquito, we also examined the same Wolbachia strains in their original host D. melanogaster. First we demonstrated that when dengue viruses were injected into D. melanogaster, virus accumulation was significantly reduced in the presence of Wolbachia, just as in A. aegypti. Second, when we carried out transcriptional analyses of the same immune genes up-regulated in the new heterologous mosquito host in response to Wolbachia we found no over-expression of these genes in D. melanogaster, infected with either wMel or wMelPop. These results reinforce the idea that the fundamental mechanism involved in viral interference in Drosophila and Aedes is not dependent on the up-regulation of the immune effectors examined, although it cannot be excluded that immune priming in the heterologous mosquito host might enhance the virus interference trait

The wMelPop strain of Wolbachia interferes with dopamine levels in Aedes aegypti

Wolbachia is an intracellular bacterium that has been stably transinfected into the mosquito vector of dengue, Aedes aegypti. This inherited infection causes a range of metabolic and phenotypic alterations in the mosquito, which might be related to neuronal abnormalities. In order to determine if these alterations were caused by the manipulation of neuroamines by this bacterium, we studied the expression of genes involved in the dopamine biosynthetic pathway and also measured the amount of dopamine in infected and uninfected mosquitoes of different ages. Wolbachia-infected mosquitoes exhibit greater expression of some genes related to the melanization pathway, but not for those directly linked to dopamine production. Although dopamine levels were higher in Wolbachia-positive mosquitoes this was not consistent across all insect ages nor was it related to the previously described Wolbachia induced "bendy" and "shaky" phenotypes

A Global Analog of Cheshire Charge

It is shown that a model with a spontaneously broken global symmetry can support defects analogous to Alice strings, and a process analogous to Cheshire charge exchange can take place. A possible realization in superfluid He-3 is pointed out.Comment: 24 pages (figures 1-4 included as uu-encoded tar files), CALT-68-1865 (Revised version: an expression (eq. 17) for global charge density is corrected; some typos and sign mismatches are removed.

New approaches to model and study social networks

We describe and develop three recent novelties in network research which are particularly useful for studying social systems. The first one concerns the discovery of some basic dynamical laws that enable the emergence of the fundamental features observed in social networks, namely the nontrivial clustering properties, the existence of positive degree correlations and the subdivision into communities. To reproduce all these features we describe a simple model of mobile colliding agents, whose collisions define the connections between the agents which are the nodes in the underlying network, and develop some analytical considerations. The second point addresses the particular feature of clustering and its relationship with global network measures, namely with the distribution of the size of cycles in the network. Since in social bipartite networks it is not possible to measure the clustering from standard procedures, we propose an alternative clustering coefficient that can be used to extract an improved normalized cycle distribution in any network. Finally, the third point addresses dynamical processes occurring on networks, namely when studying the propagation of information in them. In particular, we focus on the particular features of gossip propagation which impose some restrictions in the propagation rules. To this end we introduce a quantity, the spread factor, which measures the average maximal fraction of nearest neighbors which get in contact with the gossip, and find the striking result that there is an optimal non-trivial number of friends for which the spread factor is minimized, decreasing the danger of being gossiped.Comment: 16 Pages, 9 figure

Topologically Alice Strings and Monopoles

Symmetry breaking can produce ``Alice'' strings, which alter scattered charges and carry monopole number and charge when twisted into loops. Alice behavior arises algebraically, when strings obstruct unbroken symmetries -- a fragile criterion. We give a topological criterion, compelling Alice behavior or deforming it away. Our criterion, that \pi_o(H) acts nontrivially on \pi_1(H), links topologically Alice strings to topological monopoles. We twist topologically Alice loops to form monopoles. We show that Alice strings of condensed matter systems (nematic liquid crystals, helium 3A, and related non-chiral Bose condensates and amorphous chiral superconductors) are topologically Alice, and support fundamental monopole charge when twisted into loops. Thus they might be observed indirectly, not as strings, but as loop-like point defects. We describe other models, showing Alice strings failing our topological criterion; and twisted Alice loops supporting deposited, but not fundamental, monopole number.Comment: 2 figures; this paper consolidates preprints hep-th/0304161 and hep-th/0304162, to appear in Phys. Rev.