A two-base encoded DNA sequence alignment problem in computational biology

The recent introduction of instruments capable of producing millions of DNA sequence reads in a single run is rapidly changing the landscape of genetics. The primary objective of the "sequence alignment" problem is to search for a new algorithm that facilitates the use of two-base encoded data for large-scale re-sequencing projects. This algorithm should be able to perform local sequence alignment as well as error detection and correction in a reliable and systematic manner, enabling the direct comparison of encoded DNA sequence reads to a candidate reference DNA sequence. We will first briefly review two well-known sequence alignment approaches and provide a rudimentary improvement for implementation on parallel systems. Then, we carefully examin a unique sequencing technique known as the SOLiDTM System that can be implemented, and follow by the results from the global and local sequence alignment. In this report, the team presents an explanation of the algorithms for color space sequence data from the high-throughput re-sequencing technology and a theoretical parallel approach to the dynamic programming method for global and local alignment. The combination of the di-base approach and dynamic programming provides a possible viewpoint for large-scale re-sequencing projects. We anticipate the use of distributed computing to be the next-generation engine for large-scale problems like such

Misreporting in a randomized clinical trial for smoking cessation in adolescents

Introduction: Misreporting smoking behavior is common among younger smokers participating in clinical trials for smoking cessation. This study focused on the prevalence of and factors associated with adolescent misreporting of smoking behaviors within the context of a randomized clinical trial for smoking cessation. Methods: Adolescent smokers (N = 129) participated in a randomized clinical trial that compared two brief interventions for smoking cessation. Following the final (6-month) follow-up, a confidential, self-administered exit questionnaire examined the extent to which participants admitted to having misreported smoking quantity, frequency and/or consequences during the study. Factors associated with under- and over-reporting were compared to accurate-reporting. Results: One in 4 adolescent smokers (25.6%) admitted to under-reporting during the study and 14.7% admitted to over-reporting; 10.9% of the adolescents admitted to both under- and over-reporting. Rates of admitted misreporting did not differ between treatment conditions or recruitment site. Compared to accurate-reporting, under- and over-reporting were significantly associated with home smoking environment and the belief among adolescents that the baseline interviewer wanted them to report smoking more or less than they actually smoked. Compared to accurate reporters, over-reporters were more likely to be non-White and to report being concerned with the confidentiality of their responses. Conclusions: A post-study confidential debriefing questionnaire can be a useful tool for estimating rates of misreporting and examining whether potential differences in misreporting might bias the interpretation of treatment effects. Future studies are needed to thoroughly examine potentially addressable reasons that adolescents misreport their smoking behavior and to develop methods for reducing misreporting

The Occupational Therapy Examination and Practice Preparation (OTepp) Program: Development, Implementation and Evaluation of an Educational Program for Internationally-Educated Occupational Therapists

This paper provides a chronological overview of the development, implementation, and evaluation of an educational initiative aimed at ensuring internationally-educated occupational therapists are prepared to enter practice in their new country, Canada. The three major phases of the program’s 12-year evolution are described, to distill the key lessons learned at each phase. Data related to the demographics of participants, program content, results of the national examination, registration, and employment outcomes are included. An enhanced understanding of the transition experience of internationally educated occupational therapists provides a strong foundation from which to support internationally-educated colleagues and strengthen the occupational therapy profession

Электропривод и электрооборудование механизма подъема экскаватора ЭШ 20/90

Произведен расчёт и выбор силового оборудования для электропривода механизма подъема одноковшового экскаватора ЭШ 20/90. Исследованы статические и динамические характеристики двухконтурной системы автоматического регулирования электропривода экскаватора.The calculation and choice of power equipment for the electric drive of the lifting mechanism of the one-bucket excavator ES 20/90 is made. The static and dynamic characteristics of a two-circuit automatic control system for the electric drive of an excavator are studied

OLAC CAPC Moving Image Work-Level Records Task Force Draft Report and Recommendations, Part I: Moving Image Work Definition and Boundaries, Part II: Core Attributes and Relationships

The Moving Image Work-Level Records Task Force of Online Audiovisual Catalogers (OLAC) Cataloging Policy Committee (CAPC) was charged with investigating and making recommendations on issues related to FRBR-based work-level records for moving image materials, including, but not limited to: Identifying characteristics of moving image works (possibly with some indication of relative importance) that should be included in work-level records and creating operational definitions of these characteristics. Identifying potential sources of information about these characteristics and examining the reliability of these sources. Examining existing bibliographic records to identify places where work-level information might be recorded and investigating the possibility of extracting information from pools of existing bibliographic records to create provisional work-level records

OLAC CAPC Moving Image Work-Level Records Task Force Final Report and Recommendations, Part IV: Extracting Work-Level Information from Existing MARC Manifestation Records

This subgroup of the Moving Image Work-Level Records Task Force of Online Audiovisual Catalogers (OLAC) Cataloging Policy Committee (CAPC) was charged with identifying places in MARC manifestation-level bibliographic records where work-level information may be encoded and examining a sample of MARC records to see how reliably this information might be extrapolated from existing records. Currently we do not have work-level records for moving images, except for a relatively small number of uniform title authority records, which usually contain only title information. Moving image uniform title authority records usually represent works, but tend to include only enough information to uniquely identify the work or expression rather than a more complete description. However, information about moving image works is often embedded in our current manifestation-level bibliographic records. If we wish to move to an environment where we create and share work-level records for moving images, it would be helpful if we could use automated means to extract data from existing bibliographic records to populate provisional work-level records. These provisional records could later be enhanced, verified and corrected by human beings. Therefore, we are interested in determining the extent to which it is possible to accurately extract work-level information from existing bibliographic records

OLAC CAPC Moving Image Work-Level Records Task Force Report and Recommendations, Part I: Moving Image Work Definition and Boundaries, Part II: Core Attributes and Relationships

The Moving Image Work-Level Records Task Force of Online Audiovisual Catalogers (OLAC) Cataloging Policy Committee (CAPC) was charged with investigating and making recommendations on issues related to FRBR-based work-level records for moving image materials, including, but not limited to: Identifying characteristics of moving image works (possibly with some indication of relative importance) that should be included in work-level records and creating operational definitions of these characteristics. Identifying potential sources of information about these characteristics and examining the reliability of these sources. Examining existing bibliographic records to identify places where work-level information might be recorded and investigating the possibility of extracting information from pools of existing bibliographic records to create provisional work-level records

OLAC CAPC Moving Image Work-Level Records Task Force Final Report and Recommendations, Part IIIa: Operational Definitions: A Thought Experiment

This first section of part three examines the types of information and guidance that will be needed by catalogers in order to create, enhance, correct, and maintain work/primary expression records for moving images, which we have often referred to as work records for short

OLAC CAPC Moving Image Work-Level Records Task Force Final Report and Recommendations, Part IIIb: Data Sources

This second section of part three examines a number of primary and secondary sources that include information about moving images works and provides brief annotations of coverage, assessment of reliability, and a list of elements covered in each source. Print, and free and subscription online sources are included. Information about these sources is being entered into a relational database in the hope that it can be made available on the web in a flexible manner (e.g., by element covered, types of works covered, level of reliability, online vs. print)