Teaching: Making a Difference.[ 4th ed.]

The fourth edition of Teaching: Making a Difference, 4th Edition (Churchill et al.) draws together the voices and contemporary research of Australia’s pre-eminent education academics. The combination of their knowledge, hands-on experience and insight will help you develop your craft and technique, and provide a framework to enable you to excel as a future educator. This market-leading text is accessible for all students and designed to engage and inspire, while staying realistic, practical and jargon-free

Teaching: Making a Difference.[ 5th ed.]

When preparing pre-service teachers for their first classroom experience, academics are faced with the challenge of helping students understand what it’s really like to be a teacher. Teaching: Making a Difference, 5th Edition is a practical text that brings the classroom to life for your students. It contains all the theoretical foundations, and is supported by digital resources to demonstrate real-world applications. This market-leading text equips your students with all the tools, activities and teaching plans they need. The new fifth edition also addresses the changes in digital technology that the world has recently experienced and arms your students with the ICT competencies they’ll soon need to use in the classroom

Clinical and genetic characteristics of late-onset Huntington's disease

Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients