A Universal Multiphase Mission Execution Automaton (MEA) with Prolog Implementation for Unmanned Untethered Vehicles", Proceedings of 17th International Symposium on Unmanned Untethered Submersible Technology, Portsmouth, NH, August 2011.

Proceedings of the 17th International Symposium on Unmanned Untethered Submersible Technology, Portsmouth, NH, August, 2011

Inertial and Magnetic Posture Tracking for Inserting Humans Into Networked Virtual Environments

Proceedings of ACM Symposium on Virtual Reality Software & Technology (VRST 2001), Banff, Alberta, Canada, 15 - 17 November 2001, pp.9-16.Accepted/Published Conference Pape

Implementing an evidence-based caregiver intervention within an integrated healthcare system

The complexity of dementia care combined with the lack of care experience and external support systems creates unique burdens for the caregiver. This article describes the initial findings from the Scott & White Family Caregiver Program (FCP), the Resources for Enhancing Alzheimer's Caregiver Health (REACH II) intervention adapted for a healthcare setting. The FCP targeted one large hospital and one large ambulatory internal medicine primary care clinic within the Scott & White system. The 6-month program provided support and skills training tailored to the specific needs of caregivers based on their level of risk. At follow-up, the overall risk score, caregiver burden, and patient problem behaviors were significantly decreased and care recipient safety significantly increased. All caregivers reported that the information provided was helpful. This model successfully translated REACH II into an integrated healthcare setting and significantly reduced risks associated with dementia caregiving

‘Ethnic group’, the state and the politics of representation

The assertion, even if only by implication, that ‘ethnic group’ categories represent ‘real’ tangible entities, indeed identities, is commonplace not only in the realms of political and policy discourse but also amongst contemporary social scientists. This paper, following Brubaker (2002), questions this position in a number of key respects: of these three issues will dominate the discussion that follows. First, there is an interrogation of the proposition that those to whom the categories/labels refer constitute sociologically meaningful ‘groups’ as distinct from (mere) human collectivities. Secondly, there is the question of how these categories emerge, i.e. exactly what series of events, negotiations and contestations lie behind their construction and social acceptance. Thirdly, and as a corollary to the latter point, we explore the process of reification that leads to these categories being seen to represent ‘real things in the world’ (ibid.)

Interactions of Single-Nozzle Sonic Propulsive Deceleration Jets on Mars Entry Aeroshells

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/83612/1/AIAA-2010-4888-277.pd

Random, blocky and alternating ordering in supramolecular polymers of chemically bidisperse monomers

As a first step to understanding the role of molecular or chemical polydispersity in self-assembly, we put forward a coarse-grained model that describes the spontaneous formation of quasi-linear polymers in solutions containing two self-assembling species. Our theoretical framework is based on a two-component self-assembled Ising model in which the bidispersity is parameterized in terms of the strengths of the binding free energies that depend on the monomer species involved in the pairing interaction. Depending upon the relative values of the binding free energies involved, different morphologies of assemblies that include both components are formed, exhibiting paramagnetic-, ferromagnetic- or anti ferromagnetic-like order,i.e., random, blocky or alternating ordering of the two components in the assemblies. Analyzing the model for the case of ferromagnetic ordering, which is of most practical interest, we find that the transition from conditions of minimal assembly to those characterized by strong polymerization can be described by a critical concentration that depends on the concentration ratio of the two species. Interestingly, the distribution of monomers in the assemblies is different from that in the original distribution, i.e., the ratio of the concentrations of the two components put into the system. The monomers with a smaller binding free energy are more abundant in short assemblies and monomers with a larger binding affinity are more abundant in longer assemblies. Under certain conditions the two components congregate into separate supramolecular polymeric species and in that sense phase separate. We find strong deviations from the expected growth law for supramolecular polymers even for modest amounts of a second component, provided it is chemically sufficiently distinct from the main one.Comment: Submitted to Macromolecules, 6 figures. arXiv admin note: substantial text overlap with arXiv:1111.176

Stable Distributions in Stochastic Fragmentation

We investigate a class of stochastic fragmentation processes involving stable and unstable fragments. We solve analytically for the fragment length density and find that a generic algebraic divergence characterizes its small-size tail. Furthermore, the entire range of acceptable values of decay exponent consistent with the length conservation can be realized. We show that the stochastic fragmentation process is non-self-averaging as moments exhibit significant sample-to-sample fluctuations. Additionally, we find that the distributions of the moments and of extremal characteristics possess an infinite set of progressively weaker singularities.Comment: 11 pages, 5 figure

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer‐related mortality. Despite significant advances made in the treatment of other cancers, current chemotherapies offer little survival benefit in this disease. Pancreaticoduodenectomy offers patients the possibility of a cure, but most will die of recurrent or metastatic disease. Hence, preventing metastatic disease in these patients would be of significant benefit. Using principal component analysis (PCA), we identified a LOX/hypoxia signature associated with poor patient survival in resectable patients. We found that LOX expression is upregulated in metastatic tumors from Pdx1‐Cre KrasG12D/+ Trp53R172H/+ (KPC) mice and that inhibition of LOX in these mice suppressed metastasis. Mechanistically, LOX inhibition suppressed both migration and invasion of KPC cells. LOX inhibition also synergized with gemcitabine to kill tumors and significantly prolonged tumor‐free survival in KPC mice with early‐stage tumors. This was associated with stromal alterations, including increased vasculature and decreased fibrillar collagen, and increased infiltration of macrophages and neutrophils into tumors. Therefore, LOX inhibition is able to reverse many of the features that make PDAC inherently refractory to conventional therapies and targeting LOX could improve outcome in surgically resectable disease

Children's use of multiple categorisations in practice in a multicultural setting.

Little is known about whether and how children combine categories of race, ethnicity, language and religion in multicultural settings where more than one of these dimensions is salient. Ethnographic data from a multicultural London primary school found that children usually organised multiple categories congruently (e.g. 'If you're Indian you are Sikh'), despite strong opposition from teachers. This congruent organisation may originate in an undifferentiated experience of categories in the family, and/or represent the best 'fit' with a local population in which categories were correlated. Children used congruent organisation to infer peers' group membership, which may amplify intergroup contrasts