Implant esthetics using a Nobel Replace Standard implant vs. Nobel Perfect Scalloped implant placed in immediate extraction sockets in the esthetic zone of the maxilla.

Aims. The primary aim of this study was to compare esthetic outcomes for the Nobel Replace Standard implant vs. the Nobel Perfect Scalloped implant as determined by hard and soft tissue measurements and objective and subjective esthetic indices. Methods. 18 patients with a tooth in the maxillary esthetic zone scheduled for replacement with an immediate implant who had at least one adjacent tooth were included in the study. Nine test patients received a Nobel Perfect scalloped platform implant and 9 positive control patients received a Nobel Replace 2-stage flat platform implant. Prior to suturing a fixture level impression was taken to allow provisional fabrication by a laboratory. Implant uncovering and provisionalization occurred at 2 months after fixture placement. Final impressions were taken at 4 months and the final crown was placed at 6 months. Results. Implants platforms were placed a mean of 2.5 to 3.0 mm apical to the facial gingival margin, a mean of about 1.5 mm coronal to the facial osseous margin, and a mean of about 2.0 mm from the adjacent tooth. There was a statistically significant mean loss of osseous height on adjacent teeth of about 1.5 mm (p \u3c 0.05). with no significant differences between scalloped and standard groups (p \u3e 0.05). The osseous crest to contact distance was a mean of about 5.5 to 6.0 mm at crown placement with no significant differences between groups (p \u3e 0.05). There was minimal facial recession of about 0.3 mm at the time of crown placement and the gingival margin was harmonious with adjacent teeth 78% of the time for both scalloped and standard groups. A papilla completely filled the embrasure space in 11 of 17 sites for the scalloped group and in only 2 of 18 sites for the standard group. Thus there was papilla harmony with adjacent teeth 67% of the time for the scalloped group and only 33% of the time for the standard group. Subjective visual analog scores by the patient ranged from 98 to 99 for the scalloped group and from 93 to 94 for the standard group. Conclusions. Adjacent tooth interproximal bone loss and crest to contact distance were more than desirable but similar for both the scalloped and the standard groups. Despite this finding there was a substantially higher incidence of complete papilla formation and papilla harmony for the scalloped group. Subjective patient determined visual analog scores were consistently higher for the scalloped group. Thus there was a trend toward better esthetics with the scalloped implant at the time of crown placement

The bandmerged Planck Early Release Compact Source Catalogue: Probing sub-structure in the molecular gas at high Galactic latitude

The Planck Early Release Compact Source Catalogue (ERCSC) includes nine lists of highly reliable sources, individually extracted at each of the nine Planck frequency channels. To facilitate the study of the Planck sources, especially their spectral behaviour across the radio/infrared frequencies, we provide a "bandmerged" catalogue of the ERCSC sources. This catalogue consists of 15191 entries, with 79 sources detected in all nine frequency channels of Planck and 6818 sources detected in only one channel. We describe the bandmerging algorithm, including the various steps used to disentangle sources in confused regions. The multi-frequency matching allows us to develop spectral energy distributions of sources between 30 and 857 GHz, in particular across the 100 GHz band, where the energetically important CO J=1->0 line enters the Planck bandpass. We find ~3-5sigma evidence for contribution to the 100 GHz intensity from foreground CO along the line of sight to 147 sources with |b|>30 deg. The median excess contribution is 4.5+/-0.9 percent of their measured 100 GHz flux density which cannot be explained by calibration or beam uncertainties. This translates to 0.5+/-0.1 K km s^{-1} of CO which must be clumped on the scale of the Planck 100 GHz beam, i.e., ~10 arcmin. If this is due to a population of low mass (~15 Msun) molecular gas clumps, the total mass in these clumps may be more than 2000 Msun. Further, high-spatial-resolution, ground-based observations of the high-latitude sky will help shed light on the origin of this diffuse, clumpy CO emission.Comment: 15 pages, 15 figures, MNRAS in pres

Light-dependent N-end rule-mediated disruption of protein function in Saccharomyces cerevisiae and Drosophila melanogaster

Here we describe the development and characterization of the photo-N-degron, a peptide tag that can be used in optogenetic studies of protein function in vivo. The photo-N-degron can be expressed as a genetic fusion to the amino termini of other proteins, where it undergoes a blue light-dependent conformational change that exposes a signal for the class of ubiquitin ligases, the N-recognins, which mediate the N-end rule mechanism of proteasomal degradation. We demonstrate that the photo-N-degron can be used to direct light-mediated degradation of proteins in Saccharomyces cerevisiae and Drosophila melanogaster with fine temporal control. In addition, we compare the effectiveness of the photo-N-degron with that of two other light-dependent degrons that have been developed in their abilities to mediate the loss of function of Cactus, a component of the dorsal-ventral patterning system in the Drosophila embryo. We find that like the photo-N-degron, the blue light-inducible degradation (B-LID) domain, a light-activated degron that must be placed at the carboxy terminus of targeted proteins, is also effective in eliciting light-dependent loss of Cactus function, as determined by embryonic dorsal-ventral patterning phenotypes. In contrast, another previously described photosensitive degron (psd), which also must be located at the carboxy terminus of associated proteins, has little effect on Cactus-dependent phenotypes in response to illumination of developing embryos. These and other observations indicate that care must be taken in the selection and application of light-dependent and other inducible degrons for use in studies of protein function in vivo, but importantly demonstrate that N- and C-terminal fusions to the photo-N-degron and the B-LID domain, respectively, support light-dependent degradation in vivo

Exertional Heat Illness Risk Factors and Physiological Responses of Youth Football Players

OBJECTIVE: To determine which intrinsic and extrinsic exertional heat illness (EHI) risk factors exist in youth American football players and observe perceptual and physiological responses of players during events (games and practices). METHODS: Cross-sectional cohort study observing 63 youth football players, varying in position. Independent variables were league (weight-restricted (WR, n = 27) and age-restricted (AR, n = 36)) and event type. Dependent variables were anthropometrics, work-to-rest ratio, and wet bulb globe temperature. Descriptive variables included preparticipation examination and uniform configuration. A subset of 16 players participated in physiological variables (heart rate and gastrointestinal temperature). Data collection occurred on 7 AR and 8 WR nonconsecutive practices and the first 3 games of the season. RESULTS: Mean values for anthropometric variables were higher (p \u3c 0.05) in the AR league than the WR league. Work time (χ (1,111) = 4.232; p = 0.039) and rest time (χ (1,111) = 43.41; p \u3c 0.001) were significantly greater for games, but ratios were significantly higher for practices (χ (1,111) = 40.62; p \u3c 0.001). The majority of events (77%) observed were in black and red flag wet bulb globe temperature risk categories. A total of 57% of the players had a preparticipation examination, and up to 82% of events observed were in full uniforms. Individual gastrointestinal temperature and heart rate responses ranged widely and no players reached critical thresholds. CONCLUSION: Extrinsic (disproportionate work ratios, environmental conditions) and intrinsic (higher body mass index) EHI risk factors exist in youth football. Certain risk factors may be influenced by event and league type. National youth football organizations need to create thorough guidelines that address EHI risk factors for local leagues to adopt