Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites

Background: We have previously described an approach to predicting the substrate specificity of serine-threonine protein kinases. The method, named Predikin, identifies key conserved substrate-determining residues in the kinase catalytic domain that contact the substrate in the region of the phosphorylation site and so determine the sequence surrounding the phosphorylation site. Predikin was implemented originally as a web application written in Javascript

Effects of Nutrition During Gilt Development and Genetic Line on Farrowing Rates Through Parity 3, Causes of Culling, Sow Weights and Backfats through Parity 4, and Factors Affecting Farrowing Rates

Gilts of two genetic lines were developed with either ad libitum access to feed or energy restriction (75% of ad libitum) to determine effects on subsequent sow performance and longevity. Gilts can be developed with regimens in which energy is restricted during the growing period but the proportion that express pubertal estrus may be reduced in leaner, faster growing lines. Effects on subsequent farrowing rates are small. Sow weight and buckfat at farrowing and weaning of Parity 1 litters affect the likelihood of producing a Parity 2 litter, but these effects are dependent on lean growth rate of the line and on the gilt development regimen. Weight was important in the slower growing, fatter line developed with the restricted feeding regimen; backfat was important in the leaner, faster growing line, but the effect was twice as great in females developed with restricted feeding than for those developed with ad libitum access to feed