Bringing the Heart and Soul Back to Medicine: The Doctor as a Humanist Project

The more technical the teaching of medicine is, the more necessary the humanistic side becomes; medicine is at the crossroads between Science and the humanities; an uncertain science, perhaps. This Pop-Up event will have two sections. First, a short video recorded at the 2nd The Doctor as a Humanist symposium (Moscow, April 2019) will show what we are doing to bring back the humanities to medical education; to ask “why” the humanities are so important, and “how” we can reintroduce them to medical education. Second, we wish to debate these topics to raise interest and extend our community

Classification of evoked potentials by Pearson's correlation in a brain-computer interface

International audienceIn this paper, we describe and evaluate the performance of a linear classifier learning technique for use in a brain-computer interface. Electroencephalogram (EEG) signals acquired from individual subjets are analyzed with this technique in order to detect responses to visual stimuli. Signal processing and classification are used for implementing a palliative communication system which allows the individual to spell words. Performance with this technique is evaluated on data collected from eight individuals

Classification des potentiels évoqués par corrélation de Pearson dans une interface cerveau-ordinateur

National audienceDans cette communication, nous décrivons et évaluons les performances d'une technique d'apprentissage des coefficients d'un classifieur linéaire utilisé dans une interface cerveau-ordinateur. Les signaux de l'électroencéphalogramme d'un individu sont analysés au moyen de cette technique afin de mettre en évidence les réponses de ce dernier à des stimuli visuels. Le traitement et la classification des signaux sont utilisés afin d'implanter un système de communication palliative permettant à l'individu d'épeler des mots. Les performances de la méthode de classification ont été évaluées par une expérimentation sur huit personnes

Exponent Bounds for a Family of Abelian Difference Sets

Which groups G contain difference sets with the parameters (v, k, λ)= (q3 + 2q2 , q2 + q, q), where q is a power of a prime p? Constructions of K. Takeuchi, R.L. McFarland, and J.F. Dillon together yield difference sets with these parameters if G contains an elementary abelian group of order q2 in its center. A result of R.J. Turyn implies that if G is abelian and p is self-conjugate modulo the exponent of G, then a necessary condition for existence is that the exponent of the Sylow p-subgroup of G be at most 2q when p = 2 and at most q if p is an odd prime. In this paper we lower these exponent bounds when q ≠ p by showing that a difference set cannot exist for the bounding exponent values of 2q and q. Thus if there exists an abelian (96, 20, 4)-difference set, then the exponent of the Sylow 2-subgroup is at most 4. We also obtain some nonexistence results for a more general family of (v, k, λ)-parameter values

A comparison of classification techniques for the P300 speller

International audienceThis study assesses the relative performance characteristics of five established classification techniques on data collected using the P300 Speller paradigm, originally described by Farwell and Donchin (1988 Electroenceph. Clin. Neurophysiol. 70 510). Four linear methods: Pearson's correlation method (PCM), Fisher's linear discriminant (FLD), stepwise linear discriminant analysis (SWLDA) and a linear support vector machine (LSVM); and one nonlinear method: Gaussian kernel support vector machine (GSVM), are compared for classifying offline data from eight users. The relative performance of the classifiers is evaluated, along with the practical concerns regarding the implementation of the respective methods. The results indicate that while all methods attained acceptable performance levels, SWLDA and FLD provide the best overall performance and implementation characteristics for practical classification of P300 Speller data

Unexpected Dual Task Benefits on Cycling in Parkinson Disease and Healthy Adults: A Neuro-Behavioral Model

Background When performing two tasks at once, a dual task, performance on one or both tasks typically suffers. People with Parkinson’s disease (PD) usually experience larger dual task decrements on motor tasks than healthy older adults (HOA). Our objective was to investigate the decrements in cycling caused by performing cognitive tasks with a range of difficulty in people with PD and HOAs. Methods Twenty-eight participants with Parkinson’s disease and 20 healthy older adults completed a baseline cycling task with no secondary tasks and then completed dual task cycling while performing 12 tasks from six cognitive domains representing a wide range of difficulty. Results Cycling was faster during dual task conditions than at baseline, and was significantly faster for six tasks (all p\u3c.02) across both groups. Cycling speed improved the most during the easiest cognitive tasks, and cognitive performance was largely unaffected. Cycling improvement was predicted by task difficulty (p\u3c.001). People with Parkinson’s disease cycled slower (p\u3c.03) and showed reduced dual task benefits (p\u3c.01) than healthy older adults. Conclusions Unexpectedly, participants’ motor performance improved during cognitive dual tasks, which cannot be explained in current models of dual task performance. To account for these findings, we propose a model integrating dual task and acute exercise approaches which posits that cognitive arousal during dual tasks increases resources to facilitate motor and cognitive performance, which is subsequently modulated by motor and cognitive task difficulty. This model can explain both the improvement observed on dual tasks in the current study and more typical dual task findings in other studies

Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity

Toxoplasma gondii is a ubiquitous apicomplexan parasite capable of infecting humans and other animals. Current treatment options for T. gondii infection are limited and most have drawbacks, including high toxicity and low tolerability. Additionally, no FDA-approved treatments are available for pregnant women, a high-risk population due to transplacental infection. Therefore, the development of novel treatment options is needed. To aid this effort, this review highlights experimental compounds that, at a minimum, demonstrate inhibition of in vitro growth of T. gondii. When available, host cell toxicity and in vivo data are also discussed. The purpose of this review is to facilitate additional development of anti-Toxoplasma compounds and potentially to extend our knowledge of the parasite

Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening

Calmodulin (CaM) and phosphatidylinositol 4,5-bisphosphate (PI

De novo Assembly and Analysis of the Chilean Pencil Catfish Trichomycterus areolatus Transcriptome

Trichomycterus areolatus is an endemic species of pencil catfish that inhabits the riffles and rapids of many freshwater ecosystems of Chile. Despite its unique adaptation to Chile’s high gradient watersheds and therefore potential application in the investigation of ecosystem integrity and environmental contamination, relatively little is known regarding the molecular biology of this environmental sentinel. Here, we detail the assembly of the Trichomycterus areolatus transcriptome, a molecular resource for the study of this organism and its molecular response to the environment. RNA-Seq reads were obtained by next-generation sequencing with an Illumina® platform and processed using PRINSEQ. The transcriptome assembly was performed using TRINITY assembler. Transcriptome validation was performed by functional characterization with KOG, KEGG, and GO analyses. Additionally, differential expression analysis highlights sex-specific expression patterns, and a list of endocrine and oxidative stress related transcripts are included