End of a Dark Age?

We argue that dark matter and dark energy phenomena associated with galactic rotation curves, X-ray cluster mass profiles, and type Ia supernova data can be accounted for via small corrections to idealized general relativistic spacetime geometries due to disordered locality. Accordingly, we fit THINGS rotation curve data rivaling modified Newtonian dynamics, ROSAT/ASCA X-ray cluster mass profile data rivaling metric-skew-tensor gravity, and SCP Union2.1 SN Ia data rivaling $\Lambda$CDM without non-baryonic dark matter or a cosmological constant. In the case of dark matter, we geometrically modify proper mass interior to the Schwarzschild solution. In the case of dark energy, we modify proper distance in Einstein-deSitter cosmology. Therefore, the phenomena of dark matter and dark energy may be chimeras created by an errant belief that spacetime is a differentiable manifold rather than a disordered graph.Comment: This version was accepted for publication in the International Journal of Modern Physics D; revised version of an essay that won Honorable Mention in the Gravity Research Foundation 2016 Awards for Essays on Gravitation. 10 pages, 3 figures. arXiv admin note: text overlap with arXiv:1509.0928

The Missing Mass Problem as a Manifestation of GR Contextuality

In Newtonian gravity, mass is an intrinsic property of matter while in general relativity (GR), mass is a contextual property of matter, i.e., matter can simultaneously possess two different values of mass when it is responsible for two different spatiotemporal geometries. Herein, we explore the possibility that the astrophysical missing mass attributed to non-baryonic dark matter (DM) actually obtains because we have been assuming the Newtonian view of mass rather than the GR view. Since an exact GR solution for realistic astrophysical situations is not feasible, we explore GR-motivated ansatzes relating proper mass and dynamic mass for one and the same baryonic matter, as justified by GR contextuality. We consider four GR alternatives and find that the GR ansatz motivated by metric perturbation theory works well in fitting galactic rotation curves (THINGS data), the mass profiles of X-ray clusters (ROSAT and ASCA data) and the angular power spectrum of the cosmic microwave background (CMB, Planck 2015 data) without DM. We compare our galactic rotation curve fits to modified Newtonian dynamics (MOND), Burkett halo DM and Navarro-Frenk-White (NFW) halo DM. We compare our X-ray cluster mass profile fits to metric skew-tensor gravity (MSTG) and core-modified NFW DM. We compare our CMB angular power spectrum fit to scalar-tensor-vector gravity (STVG) and $\Lambda$CDM. Overall, we find our fits to be comparable to those of MOND, MSTG, STVG, $\Lambda$CDM, Burkett, and NFW. We present and discuss correlations and trends for the best fit values of our fitting parameters. For the most part, the correlations are consistent with well-established results at all scales, which is perhaps surprising given the simple functional form of the GR ansatz.Comment: 18 pages text. Twice revised per referee/reviewer comments. Fit of CMB angular power spectrum and dark matter halo fits adde

Self-similar structure and experimental signatures of suprathermal ion distribution in inertial confinement fusion implosions

The distribution function of suprathermal ions is found to be self-similar under conditions relevant to inertial confinement fusion hot-spots. By utilizing this feature, interference between the hydro-instabilities and kinetic effects is for the first time assessed quantitatively to find that the instabilities substantially aggravate the fusion reactivity reduction. The ion tail depletion is also shown to lower the experimentally inferred ion temperature, a novel kinetic effect that may explain the discrepancy between the exploding pusher experiments and rad-hydro simulations and contribute to the observation that temperature inferred from DD reaction products is lower than from DT at National Ignition Facility.Comment: Revised version accepted for publication in PRL. "Copyright (2015) by the American Physical Society.

Zinc stress induces copper depletion in Acinetobacter baumannii

Background: The first row transition metal ions zinc and copper are essential to the survival of many organisms, although in excess these ions are associated with significant toxicity. Here, we examined the impact of zinc and copper stress on Acinetobacter baumannii, a common opportunistic pathogen. Results: We show that extracellular zinc stress induces a copper-specific depletion phenotype in A. baumannii ATCC 17978. Supplementation with copper not only fails to rescue this phenotype, but further exacerbates the copper depletion. Extensive analysis of the A. baumannii ATCC 17978 genome identified 13 putative zinc/copper resistance efflux pumps. Transcriptional analyses show that four of these transporters are responsive to zinc stress, five to copper stress and seven to the combination of zinc and copper stress, thereby revealing a likely foundation for the zinc-induced copper starvation in A. baumannii. In addition, we show that zinc and copper play crucial roles in management of oxidative stress and the membrane composition of A. baumannii. Further, we reveal that zinc and copper play distinct roles in macrophage-mediated killing of this pathogen. Conclusions: Collectively, this study supports the targeting of metal ion homeostatic mechanisms as an effective antimicrobial strategy against multi-drug resistant bacterial pathogens.Karl A. Hassan, Victoria G. Pederick, Liam D. H. Elbourne, Ian T. Paulsen, James C. Paton, Christopher A. McDevitt and Bart A. Eijkelkam

District Space Heating Potential of Low Temperature Hydrothermal Geothermal Resources in the Southwestern United States. Technical Report.

A computer simulation model (GIRORA-Nonelectric) is developed to study the economics of district space heating using geothermal energy. GIRORA-Nonelectric is a discounted cashflow investment model which evaluates the financial return on investment for space heating. This model consists of two major submodels: the exploration for and development of a geothermal anomaly by a geothermal producer, and the purchase of geothermal fluid by a district heating unit. The primary output of the model is a calculated rate of return on investment earned by the geothermal producer. The results of the sensitivity analysis of the model subject to changes in physical and economic parameters are given in this report. Using the results of the economic analysis and technological screening criteria, all the low temperature geothermal sites in Southwestern United States are examined for economic viability for space heating application. The methodology adopted and the results are given

Involvement of Mhc Loci in immune responses that are not Ir-gene-controlled

Twenty-nine randomly chosen, soluble antigens, many of them highly complex, were used to immunize mice of two strains, C3H and B10.RIII. Lymphnode cells from the immunized mice were restimulated in vitro with the priming antigens and the proliferative response of the cells was determined. Both strains were responders to 28 of 29 antigens. Eight antigens were then used to immunize 11 congenic strains carrying different H-2 haplotypes, and the T-cell proliferative responses of these strains were determined. Again, all the strains responded to seven of the eight antigens. These experiments were then repeated, but this time -antibodies specific for the A (AA) or E (EE) molecules were added to the culture to block the in vitro responsiveness. In all but one of the responses, inhibition with both A-specific and E-specific antibodies was observed. The response to one antigen (Blastoinyces) was exceptional in that some strains were nonresponders to this antigen. Furthermore, the response in the responder strains was blocked with A-specific, but not with E-specific, antibodies. The study demonstrates that responses to antigens not controlled by Irr genes nevertheless require participation of class II Mhc molecules. In contrast to Ir gene-controlled responses involving either the A- or the E-molecule controlling loci (but never both), the responses not Ir-controlled involve participation of both A- and E-controlling loci. The lack of Ir-gene control is probably the result of complexity of the responses to multiple determinants. There is thus no principal difference between responses controlled and those not controlled by Ir genes: both types involve the recognition of the antigen, in the context of Mhc molecules

Conformation of the Solute-Binding Protein AdcAII Influences Zinc Uptake in Streptococcus pneumoniae.

Streptococcus pneumoniae scavenges essential zinc ions from the host during colonization and infection. This is achieved by the ATP-binding cassette transporter, AdcCB, and two solute-binding proteins (SBPs), AdcA and AdcAII. It has been established that AdcAII serves a greater role during initial infection, but the molecular details of how the protein selectively acquires Zn(II) remain poorly understood. This can be attributed to the refractory nature of metal-free AdcAII to high-resolution structural determination techniques. Here, we overcome this issue by separately mutating the Zn(II)-coordinating residues and performing a combination of structural and biochemical analyses on the variant proteins. Structural analyses of Zn(II)-bound AdcAII variants revealed that specific regions within the protein underwent conformational changes via direct coupling to each of the metal-binding residues. Quantitative in vitro metal-binding assays combined with affinity determination and phenotypic growth assays revealed that each of the four Zn(II)-coordinating residues contributes to metal binding by AdcAII. Intriguingly, the phenotypic growth impact of the mutant adcAII alleles was, in general, independent of affinity, suggesting that the Zn(II)-bound conformation of the SBP is crucial for efficacious metal uptake. Collectively, these data highlight the intimate coupling of ligand affinity with protein conformational change in ligand-receptor proteins and provide a putative mechanism for AdcAII. These findings provide further mechanistic insight into the structural and functional diversity of SBPs that is broadly applicable to other prokaryotes

Degrees of chloroquine resistance in Plasmodium - Is the redox system involved?

Chloroquine (CQ) was once a very effective antimalarial drug that, at its peak, was consumed in the hundreds of millions of doses per year. The drug acts against the Plasmodium parasite during the asexual intra-erythrocytic phase of its lifecycle. Unfortunately, clinical resistance to this drug is now widespread. Questions remain about precisely how CQ kills malaria parasites, and by what means some CQ-resistant (CQR) parasites can withstand much higher concentrations of the drug than others that also fall in the CQR category. In this review we investigate the evidence for and against the proposal that CQ kills parasites by generating oxidative stress. Further, we examine a long-held idea that the glutathione system of malaria parasites plays a role in CQ resistance. We conclude that there is strong evidence that glutathione levels modulate CQ response in the rodent malaria species Plasmodium berghei, but that a role for redox in contributing to the degree of CQ resistance in species infectious to humans has not been firmly established.Adele M. Lehane, Christopher A. McDevitt, Kiaran Kirk, David A. Fidoc

The Influence of Quadrature Errors on Isogeometric Mortar Methods

Mortar methods have recently been shown to be well suited for isogeometric analysis. We review the recent mathematical analysis and then investigate the variational crime introduced by quadrature formulas for the coupling integrals. Motivated by finite element observations, we consider a quadrature rule purely based on the slave mesh as well as a method using quadrature rules based on the slave mesh and on the master mesh, resulting in a non-symmetric saddle point problem. While in the first case reduced convergence rates can be observed, in the second case the influence of the variational crime is less significant

Safety and Security at Special Events: The Case of the Salt Lake City Olympic Games

Special events offer the potential for considerable threats to public safety. Perhaps no other special event rivals the Olympic Games in scope, duration, and potential for threat to communities, participants, and dignitaries. This paper reports on the results of a study of safety and security at the Salt Lake Olympic Games by a team of researchers with wide-ranging access to operations, personnel and documents from the security effort at the 2002 Winter Games. This paper focuses on three specific areas: changing definitions of safety and security during the Games; the development and maintenance of organizational structures and interaction; and lessons learned for other large-scale events. The goal of this paper is to document some of the challenges of establishing a temporary security organization. The paper concludes that building such organizations require for their success a major focus on creating a set of shared assumptions and working relationships