Parting the Green Curtain: Tracing Environmental Inequality in Portland, Oregon

This thesis utilizes a lens of environmental justice to analyze the history of Portland, Oregon and the formation of the Albina neighborhood in North Portland to understand how this community became a space of environmental inequality. Portland has been a leader in sustainable development, and yet, even with its successes, the city either been unable or unwilling to address the disproportionate impacts of environmental hazardss on low-income and communities of color in Albina. Through an examination of Portland’s history of segregation, stigmatization of Albina and its residents, housing policies, and urban renewal as they relate to Albina, this thesis traces the processes of covert institutional racism that have resulted in Albina being targeted by environmental risks. The environmental inequality faced by the Albina community stems from a history rooted in segregation and the stigmatization of people and place, through blatant racism, conscious policy making, as well as more discrete and unacknowledged forms of racism that serves to perpetuate the social and environmental problems that confront the community. Furthermore, the city’s attempts to address these issues through urban renewal projects have led to the displacement and gentrification of Albina residents. To address these issues of environmental inequality, there must first be an understanding of the processes and institutions that formed and have perpetuated these inequalities

The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease

Brain aging is marked by structural, chemical, and genetic changes leading to cognitive decline and impaired neural functioning. Further, aging itself is also a risk factor for a number of neurodegenerative disorders, most notably Alzheimer's disease (AD). Many of the pathological changes associated with aging and aging-related disorders have been attributed in part to increased and unregulated production of reactive oxygen species (ROS) in the brain. ROS are produced as a physiological byproduct of various cellular processes, and are normally detoxified by enzymes and antioxidants to help maintain neuronal homeostasis. However, cellular injury can cause excessive ROS production, triggering a state of oxidative stress that can lead to neuronal cell death. ROS and intracellular zinc are intimately related, as ROS production can lead to oxidation of proteins that normally bind the metal, thereby causing the liberation of zinc in cytoplasmic compartments. Similarly, not only can zinc impair mitochondrial function, leading to excess ROS production, but it can also activate a variety of extra-mitochondrial ROS-generating signaling cascades. As such, numerous accounts of oxidative neuronal injury by ROS-producing sources appear to also require zinc. We suggest that zinc deregulation is a common, perhaps ubiquitous component of injurious oxidative processes in neurons. This review summarizes current findings on zinc dyshomeostasis-driven signaling cascades in oxidative stress and age-related neurodegeneration, with a focus on AD, in order to highlight the critical role of the intracellular liberation of the metal during oxidative neuronal injury. © 2014 McCord and Aizenman

Is energy performance too taxing? A CAMA approach to modelling residential energy in housing in Northern Ireland

Purpose Buildings contribute significantly to CO2 production. They are also subject to considerable taxation based on value. Analysis shows that while similar attributes contribute to both value and CO2 production, there is only a loose relationship between the two. If we wish to use taxation to affect policy change (drive energy efficiency behaviour), we are unlikely to achieve this using only the current tax base (value), or by increasing the tax take off this current tax base (unlike extra taxation of cigarettes to discourage smoking, for example). Taxation of buildings on the basis of energy efficiency is hampered by the lack of current evidence of performance. This paper aims to model the now-obligatory (at sale or letting) energy performance certificate (EPC) data to derive an acceptable appraisal model (marked to market, being the EPC scores) and deploys this to the entire population of properties. This provides an alternative tax base with which to model the effects of a tax base switch to energy efficiency and to understand the tax incidence effects of such a policy. Design/methodology/approach The research uses a multiplicative hedonic approach to model energy efficiency utilising EPC holding properties in a UK jurisdiction [Northern Ireland (NI)] as the sample. This model is then used to estimate discrete energy assessments for each property in the wider population, using attributes held in the domestic rating (property tax) database for NI (700,000+ properties). This produces a robust estimate of the EPC for every property in its current condition and its cost-effective improved condition. This energy assessment based tax base is further used to estimate a new millage rate and property tax bill (green property tax) which is compared against the existing property tax based on value to allow tax incidence changes to be analysed. Findings The findings show that such a policy would significantly redistribute the tax burden and would have a variety of expected and some unexpected effects. The results indicate that while assessing the energy performance of houses can be a complex process involving many parameters, much of the explanatory power can be achieved via a relatively small number of input variables, often already held by property tax jurisdictions. This offers the opportunity for useful housing stock modelling – such as the savings possible from power switching. The research also identifies that whilst urban areas display the expected “heat island” effect in terms of energy consumption, urban properties are on average more efficient than suburban/rural properties. This facilitates spatial targeting of policy messages and initiatives. Research limitations/implications Analogous with other studies, data deficiencies introduce the risk of omitted variable bias. Modelling of the energy efficiency in the sample is limited to property attributes that are available for the wider population of properties. While this limits the modelling exercise, it is a perennial issue facing mass appraisal worldwide (where knowledge of the transacted sample attributes generally exceeds knowledge of the unsold properties). That said, the research demonstrates the benefits of sharing data and improving knowledge of the housing stock, as taxation databases would be stronger, augmented with EPC-derived property attributes for example. Originality/value The EPC lead in time for wide residential coverage is likely to be considerable. The paper contributes to emerging literature and policy debate surrounding the effect, performance measurement and implementation of energy efficiency certification, through a greater understanding of the sectorial and geographical dispersion of energy efficiency. It provides high level research to help guide policy and decision-making, identifying key locales where there is more of a physical problem and locations where there is more to gain in terms of targeting energy improvement and/or encouraging behavioural change. The paper also allows a glimpse of the implications of a change towards a taxation regime based on energy efficiency, which contributes to the debate surrounding the “greening” of property based taxes. </jats:sec

Advanced magneto-optical microscopy: Imaging from picoseconds to centimeters - imaging spin waves and temperature distributions (invited)

© 2016 Author(s).Recent developments in the observation of magnetic domains and domain walls by wide-field optical microscopy based on the magneto-optical Kerr, Faraday, Voigt, and Gradient effect are reviewed. Emphasis is given to the existence of higher order magneto-optical effects for advanced magnetic imaging. Fundamental concepts and advances in methodology are discussed that allow for imaging of magnetic domains on various length and time scales. Time-resolved imaging of electric field induced domain wall rotation is shown. Visualization of magnetization dynamics down to picosecond temporal resolution for the imaging of spin-waves and magneto-optical multi-effect domain imaging techniques for obtaining vectorial information are demonstrated. Beyond conventional domain imaging, the use of a magneto-optical indicator technique for local temperature sensing is shown

Regulation of pro-apoptotic phosphorylation of Kv2.1 K⁺ channels

Caspase activity during apoptosis is inhibited by physiological concentrations of intracellular K+. To enable apoptosis in injured cortical and hippocampal neurons, cellular loss of this cation is facilitated by the insertion of Kv2.1 K+ channels into the plasma membrane via a Zn2+ /CaMKII/SNARE-dependent process. Pro-apoptotic membrane insertion of Kv2.1 requires the dual phosphorylation of the channel by Src and p38 at cytoplasmic N- and C- terminal residues Y124 and S800, respectively. In this study, we investigate if these phosphorylation sites are mutually co-regulated, and whether putative N- and C-terminal interactions, possibly enabled by Kv2.1 intracellular cysteine residues C73 and C710, influence the phosphorylation process itself. Studies were performed with recombinant wild type and mutant Kv2.1 expressed in Chinese hamster ovary (CHO) cells. Using immunoprecipitated Kv2.1 protein and phospho-specific antibodies, we found that an intact Y124 is required for p38 phosphorylation of S800, and, importantly, that Src phosphorylation of Y124 facilitates the action of the p38 at the S800 residue. Moreover, the actions of Src on Kv2.1 are substantially decreased in the non-phosphorylatable S800A channel mutant. We also observed that mutations of either C73 or C710 residues decreased the p38 phosphorylation at S800 without influencing the actions of Src on tyrosine phosphorylation of Kv2.1. Surprisingly, however, apoptotic K+ currents were suppressed only in cells expressing the Kv2.1(C73A) mutant but not in those transfected with Kv2.1(C710A), suggesting a possible structural alteration in the C-terminal mutant that facilitates membrane insertion. These results show that intracellular N-terminal domains critically regulate phosphorylation of the C-terminal of Kv2.1, and vice versa, suggesting possible new avenues for modifying the apoptotic insertion of these channels during neurodegenerative processes

The Formation and Coarsening of the Concertina Pattern

The concertina is a magnetization pattern in elongated thin-film elements of a soft material. It is a ubiquitous domain pattern that occurs in the process of magnetization reversal in direction of the long axis of the small element. Van den Berg argued that this pattern grows out of the flux closure domains as the external field is reduced. Based on experimental observations and theory, we argue that in sufficiently elongated thin-film elements, the concertina pattern rather bifurcates from an oscillatory buckling mode. Using a reduced model derived by asymptotic analysis and investigated by numerical simulation, we quantitatively predict the average period of the concertina pattern and qualitatively predict its hysteresis. In particular, we argue that the experimentally observed coarsening of the concertina pattern is due to secondary bifurcations related to an Eckhaus instability. We also link the concertina pattern to the magnetization ripple and discuss the effect of a weak (crystalline or induced) anisotropy

The contamination of the surface of Vesta by impacts and the delivery of the dark material

The Dawn spacecraft observed the presence of dark material, which in turn proved to be associated with OH and H-rich material, on the surface of Vesta. The source of this dark material has been identified with the low albedo asteroids, but it is still a matter of debate whether the delivery of the dark material is associated with a few large impact events, to micrometeorites or to the continuous, secular flux of impactors on Vesta. The continuous flux scenario predicts that a significant fraction of the exogenous material accreted by Vesta should be due to non-dark impactors likely analogous to ordinary chondrites, which instead represent only a minor contaminant in the HED meteorites. We explored the continuous flux scenario and its implications for the composition of the vestan regolith, taking advantage of the data from the Dawn mission and the HED meteorites. We used our model to show that the stochastic events scenario and the micrometeoritic flux scenario are natural consequences of the continuous flux scenario. We then used the model to estimate the amounts of dark and hydroxylate materials delivered on Vesta since the LHB and we showed how our results match well with the values estimated by the Dawn mission. We used our model to assess the amount of Fe and siderophile elements that the continuous flux of impactors would mix in the vestan regolith: concerning the siderophile elements, we focused our attention on the role of Ni. The results are in agreement with the data available on the Fe and Ni content of the HED meteorites and can be used as a reference frame in future studies of the data from the Dawn mission and of the HED meteorites. Our model cannot yet provide an answer to the fate of the missing non-carbonaceous contaminants, but we discuss possible reasons for this discrepancy.Comment: 31 pages, 7 figures, 4 tables. Accepted for publication on the journal ICARUS, "Dark and Bright Materials on Vesta" special issu

Contribution of Smoking to Excess Mortality in Harlem

The New York City neighborhood of Harlem has mortality rates that are among the highest in the United States. In absolute numbers, cardiovascular disease and cancer account for the overwhelming majority of deaths, especially among men, and these deaths occur at relatively young ages. The aim of this research was to examine self-reported smoking habits according to measures of socioeconomic status among Harlem men and women, in order to estimate the contribution of tobacco consumption to Harlem's remarkably high excess mortality. During 1992-1994, in-person interviews were conducted among 695 Harlem adults aged 18-65 years who were randomly selected from dwelling unit enumeration lists. The self-reported prevalence of current smoking was strikingly high among both men (48%) and women (41%), even among highly educated men (38%). The 21% of respondents without working telephones reported an even higher prevalence of current smoking (61%), indicating that national and state-based estimates which rely on telephone surveys may seriously underestimate the prevalence of smoking in poor urban communities. Among persons aged 35-64 years, the smoking attributable fractions for selected causes of death were larger in Harlem than in either New York City as a whole or the entire United States for both men and women. Tobacco consumption is likely to be one of several important mediators of the high numbers of premature deaths in Harlem. Am J Epidemiol 1998; 147: 250-