Klipsun Magazine, 1985, Volume 16, Issue 04 - March

https://cedar.wwu.edu/klipsun_magazine/1080/thumbnail.jp

Klipsun Magazine, 1985, Volume 16, Issue 05 - April

https://cedar.wwu.edu/klipsun_magazine/1081/thumbnail.jp

University of Virginia acquisition of passenger ride quality data aboard the Total In-Flight Simulator (TIFS)

The subjective response of passengers to vehicle motions was investigated on the Total In-Flight Simulator (TIFS) aircraft. Prerecorded signals were converted into controlled aircraft motion for evaluation by ten subjects on a seven-point rating scale. Eighteen test flights were flown on August and September 1974, the results of which are to be used in validation studies on ground based simulators at NASA/Langley Research Center and to extend passenger response models

Claiming One Future for Digital Humanities: Undergraduate Learning, Creation, & Ownership

Discussions and scholarship in Digital Humanities often don’t include undergraduates. But they should. The field represents an important frontier for teaching, learning, and scholarship, and not just for researchers or for graduate students. Incorporating digital tools in the humanities can and should be a key part of the undergraduate research experience. One path for Digital Humanities embraces the idea that undergraduate students should be active participants in the consumption, analysis, and construction of knowledge, claiming for themselves roles as learners, creators, and owners

Bibliography of the space processing program. Volume 1: A compilation through June 1974, Parts 1 and 2

A compilation of NASA research efforts in the area of space environmental effects on materials and processes is presented. Topics considered are: (1) fluid mechanics and heat transfer; (2) crystal growth and containerless melts; (3) acoustics; (4) glass and ceramics; (5) electrophoresis; (6) welding; and (7) exobiology

Integrating Digital Humanities in Pedagogy: Choosing Courses, Learning Objectives and Tools

This workshop will be aimed at working through the practical and pedagogical choices about creating a digital humanities course. We will explore sample syllabi, discuss potential projects, survey various tools, and identify obvious and not-so-obvious pitfalls to constructing a class that engages students in the scholarship and practice related to digital humanities. Not in the humanities? Come join us anyway. Most of these ideas and approaches apply to incorporating technology into any course

969-99 Biocompatible Mechanical Left Ventricular Support: Potential Alternative to Transplantation

Use of mechanical circulatory support has been limited by its associated bleeding and thrombotic complications. Blood contact with an artificial surface results in a well-deined pattern of hematologic alterations. The TCI HeartMate® left ventricular assist device (LVAD) is an implantable circulatory support pump currently used as a bridge to transplantation. Its textured blood contacting surfaces result in a formation of an adherent pseudoneointimal lining which eliminates the direct interaction of blood elements with the artificial surface. To determine if this biological lining could mitigate the stereotypical blood-synthetic surface interactions, we studied eight patients who underwent implantation at our institution over a 10 month period from 5/93 to 3/94. Seven of the 8 patients were bridged to transplantation. Three patients were transplanted within 10 days and one month data could not be obtained. Hemodynamic and hemostatic parameters (mean±sd) were studied as follows:Pre-implantPOD 7POD 28Cardiac index (I/min/m2)1.8±0.73.2±0.43.1±0.5Systolic BP (mmHg)759±6.8125.8±9.7130.4±8.1Hemoglobin (mg/dl)7.4±1.88.2±1.69.6±2.0Plasma free hemoglobin (mg/dl)15.4±1.76.4±2.36.8±1.9Prothrombin time (sec)14.2±1.113.4±0.713.3±0.7Partial thromboplastin time (sec)56.7±15.931.8±4.837.6±11.9Platelet count (× 103lcu mm)250±81269±63325±37In vitro platelet reactivity to the agonist ADP remained normal pre and post implantation. Average perioperative blood requirements included PRBC, 3.3±1.3 units; platelets, 2.3±4.5 units; fresh frozen plasma, 2±1.9 units. No blood products were required after postoperative day 2.We conclude that TCI LVAD support improves hemodynamics and can bridge patients in pre-implant cardiogenic shock to transplantation. Furthermore, no red cell destruction or hemostatic and thrombotic complications were observed despite one month of support without anticoagulation therapy. Therefore, as the donor shortage continues, LVADs with biocompatible surfaces may provide an alternative to cardiac transplantation

A Germline Clone Screen on the X Chromosome Reveals Novel Meiotic Mutants in Drosophila melanogaster

In an effort to isolate novel meiotic mutants that are severely defective in chromosome segregation and/or exchange, we employed a germline clone screen of the X chromosome of Drosophila melanogaster. We screened over 120,000 EMS-mutagenized chromosomes and isolated 19 mutants, which comprised nine complementation groups. Four of these complementation groups mapped to known meiotic genes, including mei-217, mei-218, mei-9, and nod. Importantly, we have identified two novel complementation groups with strong meiotic phenotypes, as assayed by X chromosome nondisjunction. One complementation group is defined by three alleles, and the second novel complementation group is defined by a single allele. All 19 mutants are homozygous viable, fertile, and fully recessive. Of the 9 mutants that have been molecularly characterized, 5 are canonical EMS-induced transitions, and the remaining 4 are transversions. In sum, we have identified two new genes that are defined by novel meiotic mutants, in addition to isolating new alleles of mei-217, mei-218, mei-9, and nod