315 research outputs found

    The Opportunities and Challenges of Internet of Things Evidence in Regard to Criminal Investigations

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    As internet-connected devices become more prevalent, the need for police and law enforcement to be able to utilize these devices when solving crimes steadily increases. Law enforcement agencies are already aware of the opportunities and challenges when interacting with computers and mobile cellular devices, but many agencies are unable to utilize these avenues of evidence because of limited access to resources able to forensically examine computing devices. In addition, the introduction of internet of things devices, such as Amazon Alexa and other microphone or camera connected devices, allows new opportunities for law enforcement agencies to gather digital forensic evidence either to convict a criminal or to solve a crime. This study will explore both the opportunities and challenges of using Internet of Things evidence for law enforcement purposes by analyzing Internet of Things legal cases as well as articles and research about the Internet of Things and digital evidence

    Admissibility of an Accomplice\u27s Confession against a Non-Confessing Defendant

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    Low-Stress Bicycle Lanes for the Urban Core's High-Stress Streets.

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    D.Arch. Thesis. University of Hawaiʻi at Mānoa 2018

    INVESTIGATING THE IMPACT OF INTERACTIVE APPLETS ON STUDENTS’ UNDERSTANDING OF PARAMETER CHANGES TO PARENT FUNCTIONS: AN EXPLANATORY MIXED METHODS STUDY

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    The technology principle in the Principles and Standards for School Mathematics (NCTM, 2000) states that technology plays an important role in how teachers teach mathematics and in how students learn mathematics. The purpose of this sequential explanatory mixed-methods study was to examine the impact of interactive applets on students’ understanding of parameter changes to parent functions. Students in the treatment classes were found to have statistically significantly higher posttest scores than students in the control classes. Although the data analysis showed a statistically significant difference between classes on procedural understanding, no statistically significant difference was found with regard to conceptual understanding. Student and teacher interviews provided insight on how and why the use of applets helped or hindered students’ understanding of parameter changes to parent functions

    Gentamicin pharmacokinetics during slow daily home hemodialysis

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    Gentamicin pharmacokinetics during slow daily home hemodialysis.BackgroundGentamicin is commonly used in hemodialysis patients. Gentamicin pharmacokinetics during traditional hemodialysis have been described. Slow daily home (SDH) hemodialysis (7 to 9 hours a day/6 days a week) use is increasing due to benefits observed with increased hemodialysis. We determined gentamicin pharmacokinetics for SDH hemodialysis patients.MethodsEight patients (four male and four female) received a single intravenous dose of 0.6 mg/kg gentamicin post-hemodialysis. Blood samples were collected at 5, 10, 15, 30, and 60 minutes after dose. The next day patients underwent a typical SDH hemodialysis (high-flux F50NR dialyzer) session. Blood samples were taken at 0, 5, 15, 60, 120, 240, 360, 480 minutes during and 15, 30 and 60 minutes post-hemodialysis. Baseline and 24-hour urine samples were collected. Pharmacokinetic parameters were calculated assuming a one-compartment model.ResultsPatients were 42.5 ± 13.1 years old (mean ± SD). Inter-, intra-, and post-hemodialysis collection periods were 17.0 ± 2.1 hours, 8.1 ± 0.4 hours, and 1.1 ± 0.1 hours, respectively. Intra-, and interdialytic gentamicin half-lives were different (intradialytic, 3.7 ± 0.8 hours; interdialytic, 20.4 ± 4.7 hours; P < 0.0001). Hemodialysis clearance accounted for 70.5% gentamicin total clearance. Renal clearance correlated with glomerular filtration rate (GFR) (renal clearance = 1.2 GFR; r2 = 0.98; P < 0.001). Mean peak and trough of hemodialysis concentrations were 1.8 ± 0.6 μg/mL and 0.5 ± 0.2 μg/mL, respectively. Post-hemodialysis rebound was 3.1 ± 8.8% at 1 hour.ConclusionPharmacokinetic model predicts 2.0 to 2.5 mg/kg dose gentamicin post-hemodialysis would provide peak (1 hour post-dose) and trough (end of SDH hemodialysis session) concentrations of 6.0 to 7.5 μg/mL and 0.7 to 0.8 μg/mL, respectively. This would provide adequate coverage for most gram-negative organisms in SDH hemodialysis patients
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