Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ.

Cystic kidney diseases (CKDs) affect millions of people worldwide. The defining pathological features are fluid-filled cysts developing from nephric tubules due to defective flow sensing, cell proliferation and differentiation. The underlying molecular mechanisms, however, remain poorly understood, and the derived excretory systems of established invertebrate models (Caenorhabditis elegans and Drosophila melanogaster) are unsuitable to model CKDs. Systematic structure/function comparisons revealed that the combination of ultrafiltration and flow-associated filtrate modification that is central to CKD etiology is remarkably conserved between the planarian excretory system and the vertebrate nephron. Consistently, both RNA-mediated genetic interference (RNAi) of planarian orthologues of human CKD genes and inhibition of tubule flow led to tubular cystogenesis that share many features with vertebrate CKDs, suggesting deep mechanistic conservation. Our results demonstrate a common evolutionary origin of animal excretory systems and establish planarians as a novel and experimentally accessible invertebrate model for the study of human kidney pathologies

Assessing Parents' Perception of Children's Risk for Recreational Water Illnesses

Understanding people's risk perceptions and motivations to adopt preventive behavior is important in preventing the spread of recreational water illnesses (RWI) and other emerging infectious diseases. We developed a comprehensive scale measuring parents' perceived risk of their children contracting RWI. Parents (N = 263) completed a self-administered questionnaire with scale items based on 4 constructs of the Protection Motivation Theory: perceived vulnerability, perceived severity, response efficacy, and self-efficacy. Exploratory factor analysis identified 7 underlying factors, indicating 7 subscales of perceived risk for RWI. Cronbach α ranged from 0.60 to 0.81. The Precaution Adoption Process Model supported scale construct validity. This study provides the first perceived risk scale for exploring psychosocial factors that may predict or mediate the adoption of behaviors that prevent the spread of infectious diseases contracted by children while swimming. Findings from this study also provide implications for encouraging preventive behavior against other emerging infectious diseases

Relaying: An Intercropping Approach to the Co-culture of Crawfish and Rice (Bulletin #862)

This study was designed to examine the biological and economic efficacy of relaying crawfish into a growing rice crop in an intercropping manner.https://digitalcommons.lsu.edu/agcenter_bulletins/1041/thumbnail.jp

Adventures in Thermal Duality (II): Towards a Duality-Covariant String Thermodynamics

In a recent companion paper, we observed that the rules of ordinary thermodynamics generally fail to respect thermal duality, a symmetry of string theory under which the physics at temperature T is related to the physics at the inverse temperature 1/T. Even when the free energy and internal energy exhibit the thermal duality symmetry, the entropy and specific heat are defined in such a way that this symmetry is destroyed. In this paper, we propose a modification of the traditional definitions of these quantities, yielding a manifestly duality-covariant thermodynamics. At low temperatures, these modifications produce "corrections" to the standard definitions of entropy and specific heat which are suppressed by powers of the string scale. These corrections may nevertheless be important for the full development of a consistent string thermodynamics. We find, for example, that the string-corrected entropy can be smaller than the usual entropy at high temperatures, suggesting a possible connection with the holographic principle. We also discuss some outstanding theoretical issues prompted by our approach.Comment: 31 pages, 6 figures, 1 conversatio

Exploration of a Polarized Surface Bidirectional Reflectance Model Using the Ground-Based Multiangle Spectropolarimetric Imager

Accurate characterization of surface reflection is essential for retrieval of aerosols using downward-looking remote sensors. In this paper, observations from the Ground-based Multiangle SpectroPolarimetric Imager (GroundMSPI) are used to evaluate a surface polarized bidirectional reflectance distribution function (PBRDF) model. GroundMSPI is an eight-band spectropolarimetric camera mounted on a rotating gimbal to acquire pushbroom imagery of outdoor landscapes. The camera uses a very accurate photoelastic-modulator-based polarimetric imaging technique to acquire Stokes vector measurements in three of the instrument's bands (470, 660, and 865 nm). A description of the instrument is presented, and observations of selected targets within a scene acquired on 6 January 2010 are analyzed. Data collected during the course of the day as the Sun moved across the sky provided a range of illumination geometries that facilitated evaluation of the surface model, which is comprised of a volumetric reflection term represented by the modified Rahman-Pinty-Verstraete function plus a specular reflection term generated by a randomly oriented array of Fresnel-reflecting microfacets. While the model is fairly successful in predicting the polarized reflection from two grass targets in the scene, it does a poorer job for two manmade targets (a parking lot and a truck roof), possibly due to their greater degree of geometric organization. Several empirical adjustments to the model are explored and lead to improved fits to the data. For all targets, the data support the notion of spectral invariance in the angular shape of the unpolarized and polarized surface reflection. As noted by others, this behavior provides valuable constraints on the aerosol retrieval problem, and highlights the importance of multiangle observations.NASAJPLCenter for Space Researc

Ramond-Ramond Central Charges in the Supersymmetry Algebra of the Superstring

The free action for the massless sector of the Type II superstring was recently constructed using closed RNS superstring field theory. The supersymmetry transformations of this action are shown to satisfy an N=2 D=10 SUSY algebra with Ramond-Ramond central charges.Comment: 10 pages harvmac te