Cosmic Star Formation History and its Dependence on Galaxy Stellar Mass

We examine the cosmic star formation rate (SFR) and its dependence on galaxy stellar mass over the redshift range 0.8 < z < 2 using data from the Gemini Deep Deep Survey (GDDS). The SFR in the most massive galaxies (M > 10^{10.8} M_sun) was six times higher at z = 2 than it is today. It drops steeply from z = 2, reaching the present day value at z ~ 1. In contrast, the SFR density of intermediate mass galaxies (10^{10.2} < M < 10^{10.8} M_sun) declines more slowly and may peak or plateau at z ~ 1.5. We use the characteristic growth time t_SFR = rho_M / rho_SFR to provide evidence of an associated transition in massive galaxies from a burst to a quiescent star formation mode at z ~ 2. Intermediate mass systems transit from burst to quiescent mode at z ~ 1, while the lowest mass objects undergo bursts throughout our redshift range. Our results show unambiguously that the formation era for galaxies was extended and proceeded from high to low mass systems. The most massive galaxies formed most of their stars in the first ~3 Gyr of cosmic history. Intermediate mass objects continued to form their dominant stellar mass for an additional ~2 Gyr, while the lowest mass systems have been forming over the whole cosmic epoch spanned by the GDDS. This view of galaxy formation clearly supports `downsizing' in the SFR where the most massive galaxies form first and galaxy formation proceeds from larger to smaller mass scales.Comment: Accepted for publication in ApJ

Evolved Galaxies at z > 1.5 from the Gemini Deep Deep Survey: The Formation Epoch of Massive Stellar Systems

We present spectroscopic evidence from the Gemini Deep Deep Survey (GDDS) for a significant population of color-selected red galaxies at 1.3 < z < 2.2 whose integrated light is dominated by evolved stars. Unlike radio-selected objects, the z > 1.5 old galaxies have a sky density > 0.1 per sq. arcmin. Conservative age estimates for 20 galaxies with z > 1.3; = 1.49, give a median age of 1.2 Gyr and = 2.4. One quarter of the galaxies have inferred z_f > 4. Models restricted to abundances less than or equal to solar give median ages and z_f of 2.3 Gyr and 3.3, respectively. These galaxies are among the most massive and contribute approximately 50% of the stellar mass density at 1 < z < 2. The derived ages and most probable star formation histories suggest a high star-formation-rate (300-500 solar masses per year) phase in the progenitor population. We argue that most of the red galaxies are not descendants of the typical z=3 Lyman break galaxies. Galaxies associated with luminous sub-mm sources have the requisite star formation rates to be the progenitor population. Our results point toward early and rapid formation for a significant fraction of present day massive galaxies.Comment: 12 pages, 2 figures, 1 table, Accepted for publication, ApJ Letter

Human Papillomavirus Awareness in Haiti: Preparing for a National HPV Vaccination Program

Cervical cancer morbidity and mortality are pressing public health issues impacting women in Haiti. To inform efforts to develop a human papillomavirus (HPV) vaccination program in Haiti, we sought to understand HPV awareness and willingness to get HPV vaccination in Haiti

Red Nuggets at z~1.5: Compact passive galaxies and the formation of the Kormendy Relation

We present the results of NICMOS imaging of a sample of 16 high mass passively evolving galaxies with 1.3<z<2, taken primarily from the Gemini Deep Deep Survey. Around 80% of galaxies in our sample have spectra dominated by stars with ages >1 Gyr. Our rest-frame R-band images show that most of these objects have compact regular morphologies which follow the classical R^1/4 law. These galaxies scatter along a tight sequence in the Kormendy relation. Around one-third of the massive red objects are extraordinarily compact, with effective radii under one kiloparsec. Our NICMOS observations allow the detection of such systems more robustly than is possible with optical (rest-frame UV) data, and while similar systems have been seen at z>2, this is the first time such systems have been detected in a rest-frame optical survey at 1.3<z<2. We refer to these compact galaxies as "red nuggets". Similarly compact massive galaxies are completely absent in the nearby Universe. We introduce a new "stellar mass Kormendy relation" (stellar mass density vs size) which isolates the effects of size evolution from those of luminosity and color evolution. The 1.1 < z < 2 passive galaxies have mass densities that are an order of magnitude larger then early type galaxies today and are comparable to the compact distant red galaxies at 2 < z < 3. We briefly consider mechanisms for size evolution in contemporary models focusing on equal-mass mergers and adiabatic expansion driven by stellar mass loss. Neither of these mechanisms appears able to transform the high-redshift Kormendy relation into its local counterpart. Comment: Accepted version (to appear in ApJ

The Gemini Deep Deep Survey: II. Metals in Star-Forming Galaxies at Redshift 1.3<z<2

The goal of the Gemini Deep Deep Survey (GDDS) is to study an unbiased sample of K<20.6 galaxies in the redshift range 0.8<z<2.0. Here we determine the statistical properties of the heavy element enrichment in the interstellar medium (ISM) of a subsample of 13 galaxies with 1.34<z<1.97 and UV absolute magnitude M_2000 < -19.65. The sample contains 38% of the total number of identified galaxies in the first two fields of the survey with z>1.3. The selected objects have colors typical of irregular and Sbc galaxies. Strong [OII] emission indicates high star formation activity in the HII regions (SFR~13-106 M_sun/yr). The high S/N composite spectrum shows strong ISM MgII and FeII absorption, together with weak MnII and MgI lines. The FeII column density, derived using the curve of growth analysis, is logN_FeII = 15.54^{+0.23}_{-0.13}. This is considerably larger than typical values found in damped Ly-alpha systems (DLAs) along QSO sight lines, where only 10 out of 87 (~11%) have logN_FeII > 15.2. High FeII column densities are observed in the z=2.72 Lyman break galaxy cB58 (logN_FeII ~ 15.25) and in gamma-ray burst host galaxies (logN_FeII ~ 14.8-15.9). Given our measured FeII column density and assuming a moderate iron dust depletion (delta_Fe ~ 1 dex), we derive an optical dust extinction A_V ~ 0.6. If the HI column density is log N(HI)<21.7 (as in 98% of DLAs), then the mean metallicity is Z/Z_sun > 0.2. The high completeness of the GDDS sample implies that these results are typical of star-forming galaxies in the 1<z<2 redshift range, an epoch which has heretofore been particularly challenging for observational programs.Comment: ApJ in press, corrected HI column density estimat

Awareness of Cervical Cancer Causes and Predeterminants of Likelihood to Screen Among Women in Haiti:

Cervical cancer is the leading cause of cancer deaths among women in Haiti. Given this high disease burden, we sought to better understand women's knowledge of its causes and the sociodemographic and health correlates of cervical cancer screening. Participants were 410 adult women presenting at clinics in Léogâne and Port-au-Prince, Haiti. We used bivariate and multivariate logic regression to identify correlates of Pap smear receipt. Only 29% of respondents had heard of human papillomavirus (HPV), whereas 98% were aware of cervical cancer. Of those aware of cervical cancer, 12% believed that sexually transmitted infections (STIs) cause it, and only 4% identified HPV infection as the cause. Women with a previous sexually transmitted infection were more likely to have had Pap smear (34% vs 71%, odds ratio = 3.45; 95% CI = 1.57-7.59). Screening was also more likely among women who were older than the age of 39 years, better educated, and employed (all p < .05). Almost all women (97%) were willing to undergo cervical cancer screening. This sample of Haitian women had limited awareness of HPV and cervical cancer causes; but when provided with health information, they saw the benefits of cancer screening. Future initiatives should provide health education messages, with efforts targeting young and at-risk women

Gemini Deep Deep Survey VI: Massive Hdelta-strong galaxies at z=1

We show that there has been a dramatic decline in the abundance of massive galaxies with strong Hdelta stellar absorption lines from z=1.2 to the present. These ``Hdelta-strong'', or HDS, galaxies have undergone a recent and rapid break in their star-formation activity. Combining data from the Gemini Deep Deep and the Sloan Digital Sky Surveys to make mass-matched samples (M*>=10^10.2 Msun), with 25 and 50,255 galaxies, respectively), we find that the fraction of galaxies in an HDS phase has decreased from about 50% at z=1.2 to a few percent today. This decrease in fraction is due to an actual decrease in the number density of massive HDS systems by a factor of 2-4, coupled with an increase in the number density of massive galaxies by about 30 percent. We show that this result depends only weakly on the threshold chosen for the Hdelta equivalent width to define HDS systems (if greater than 4 A) and corresponds to a (1+z)^{2.5\pm 0.7} evolution. Spectral synthesis studies of the high-redshift population using the PEGASE code, treating Hdelta_A, EW[OII], Dn4000, and rest-frame colors, favor models in which the Balmer absorption features in massive Hdelta-strong systems are the echoes of intense episodes of star-formation that faded about 1 Gyr prior to the epoch of observation. The z=1.4-2 epoch appears to correspond to a time at which massive galaxies are in transition from a mode of sustained star formation to a relatively quiescent mode with weak and rare star-formation episodes. We argue that the most likely local descendants of the distant massive HDS galaxies are passively evolving massive galaxies in the field and small groups.Comment: 16 pages, 12 figures, 3 tables, uses emulateapj.sty; updated to match the version accepted by ApJ. One figure added, conclusions unchange

MICA: a multi-omics method to predict gene regulatory networks in early human embryos

Recent advances in single-cell omics have transformed characterisation of cell types in challenging-to-study biological contexts. In contexts with limited single-cell samples, such as the early human embryo inference of transcription factor-gene regulatory network (GRN) interactions is especially difficult. Here, we assessed application of different linear or non-linear GRN predictions to single-cell simulated and human embryo transcriptome datasets. We also compared how expression normalisation impacts on GRN predictions, finding that transcripts per million reads outperformed alternative methods. GRN inferences were more reproducible using a non-linear method based on mutual information (MI) applied to single-cell transcriptome datasets refined with chromatin accessibility (CA) (called MICA), compared with alternative network prediction methods tested. MICA captures complex non-monotonic dependencies and feedback loops. Using MICA, we generated the first GRN inferences in early human development. MICA predicted co-localisation of the AP-1 transcription factor subunit proto-oncogene JUND and the TFAP2C transcription factor AP-2γ in early human embryos. Overall, our comparative analysis of GRN prediction methods defines a pipeline that can be applied to single-cell multi-omics datasets in especially challenging contexts to infer interactions between transcription factor expression and target gene regulation

The Gemini Deep Deep Survey: I. Introduction to the Survey, Catalogs and Composite Spectra

The Gemini Deep Deep Survey (GDDS) is an ultra-deep (K<20.6 mag, I<24.5 mag) redshift survey targeting galaxies in the "redshift desert" between 1<z<2. The primary goal of the survey is to constrain the space density at high redshift of evolved high-mass galaxies. We obtained 309 spectra in four widely-separated 30 arcmin^2 fields using the Gemini North telescope and the Gemini Multi-Object Spectrograph (GMOS). The spectra define a one-in-two sparse sample of the reddest and most luminous galaxies near the I-K vs. I color-magnitude track mapped out by passively evolving galaxies in the redshift interval 0.8<z<1.8. This sample is augmented by a one-in-seven sparse sample of the remaining high-redshift galaxy population. Typical exposures times were 20-30 hours per field (in Nod & Shuffle mode), and the resulting spectra are the deepest ever obtained. In this paper we present our sample of 309 spectra, along with redshifts, identifications of spectral features, and photometry. The infrared selection underlying the survey means that the GDDS is observing not only star-forming galaxies, as in most high-redshift galaxy surveys, but also quiescent evolved galaxies. The median redshift of the whole GDDS sample is z=1.1. Together with the data and catalogs, we present a summary of the criteria for selecting the GDDS fields, the rationale behind our mask designs, an analysis of the completeness of the survey, and a description of the data reduction procedures used. All data from the GDDS are publicly available. (ABRIDGED)Comment: Accepted for publication in AJ. This paper makes very heavy use of color. A nicer PDF version of this paper with full-resolution figures is available at the GDDS web site: http://www.ociw.edu/lcirs/gdds.htm