Counterfeit Currency of the Confederate States of America

Dubious dollars New reference sheds light on economic enterprise George B. Tremmel\u27s book is a fine addition to the existing literature on counterfeit currency of the Confederate States of America. It contains a good review of the period history and is well written. Counterfe...

Importance of Cement Market Characteristics to the Industrial Geologist

Author Institution: Mineral Economics Department, College of Mineral Industries, The Pennsylvania State University, University Park, PennsylvaniaDecisions to develop deposits of calcareous materials for cement production are based largely on anticipated markets for heavy construction which utilizes concrete. The geologist should understand the fundamental factors that underlie such management decisions, so that his field work and reports will more effectively relate to the information requirements of managers in the cement industry. The paper examines the relationships that exist between exploration and development of calcareous raw materials for cement manufacture and changing factors in the marketing of cement. Continued overcapacity, improved technology, changing distribution patterns,ease of entry, economics of scale, and the nature of product demand are some of thecharacteristics of the cement industry that are basic to decisions regarding explorationprograms and property development

TXSSAR State Records

Minutes from an annual meeting of the Texas Sons of the American Revolution, held on July 5, 2004 at 9:00 a.m., including a summary of activities and business discussed. The meeting was called to order by President General Raymond Musgrave. Included are the minutes from the July 6 and July 7, 2004 meetings, called to order by President General Raymond Musgrave

Discovery of BIO-8169A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation

Interleukin receptor associated kinase 4 (IRAK4) plays an important role in innate immune signaling through Toll-like and interleukin-1 receptors and represents an attractive target for the treatment of inflammatory diseases and cancer. We previously reported the development of a potent, selective, and brain-penetrant imidazopyrimidine series of IRAK4 inhibitors. However, lead molecule BIO-7488 (1) suffered from low solubility which led to variable PK, compound accumulation, and poor in vivo tolerability. Herein, we describe the discovery of a series of pyridone analogs with improved solubility which are highly potent, selective and demonstrate desirable PK profiles including good oral bioavailability and excellent brain penetration. BIO-8169 (2) reduced the in vivo production of pro-inflammatory cytokines, was well tolerated in safety studies in rodents and dog at margins well above the predicted efficacious exposure and showed promising results in a mouse model for multiple sclerosis

Discovery of BIO-8169A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation

Interleukin receptor associated kinase 4 (IRAK4) plays an important role in innate immune signaling through Toll-like and interleukin-1 receptors and represents an attractive target for the treatment of inflammatory diseases and cancer. We previously reported the development of a potent, selective, and brain-penetrant imidazopyrimidine series of IRAK4 inhibitors. However, lead molecule BIO-7488 (1) suffered from low solubility which led to variable PK, compound accumulation, and poor in vivo tolerability. Herein, we describe the discovery of a series of pyridone analogs with improved solubility which are highly potent, selective and demonstrate desirable PK profiles including good oral bioavailability and excellent brain penetration. BIO-8169 (2) reduced the in vivo production of pro-inflammatory cytokines, was well tolerated in safety studies in rodents and dog at margins well above the predicted efficacious exposure and showed promising results in a mouse model for multiple sclerosis