5 research outputs found
Prion protein heterogeneity in sporadic but not variant Creutzfeldt-Jakob disease: U.K. cases 1991-2002
Human prion diseases can occur as an idiopathic disorder (sporadic CreutzfeldtâJakob disease) or can be acquired, as is the case for variant CreutzfeldtâJakob disease. These disorders are characterized by the accumulation of a protease-resistant form of the host-encoded prion protein termed PrPSc in the brains of affected individuals. PrPSc has been proposed to be the principal, if not sole, component of the infectious agent, with its accumulation in the central nervous system the primary event leading to neurodegeneration. A major question remains as to whether self-propagating structural differences in PrPSc might account for the clinicopathological diversity evident in CreutzfeldtâJakob disease and whether different prion protein types underlie the existence of different strains of causative agent. Here, we describe the results of a large-scale biochemical study of PrPSc from autopsy-proved cases of variant CreutzfeldtâJakob disease (n = 59) and compare these with cases of sporadic CreutzfeldtâJakob disease (n = 170) in the United Kingdom over the period 1991 to 2002. The results show PrPSc in variant CreutzfeldtâJakob disease to be remarkably stereotyped. In contrast, considerable heterogeneity in PrPSc exists both between and within cases of sporadic CreutzfeldtâJakob disease
Disagreement and the Informativeness of Stock Returns: The Case of Acquisition Announcements
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