Purposeful empiricism: how stochastic modeling informs industrial marketing research

It is increasingly recognized that progress can be made in the development of integrated theory for understanding, explaining and better predicting key aspects of buyer–seller relationships and industrial networks by drawing upon non-traditional research perspectives and domains. One such non-traditional research perspective is stochastic modeling which has shown that large scale regularities emerge from the individual interactions between idiosyncratic actors. When these macroscopic patterns repeat across a wide range of firms, industries and business types this commonality suggests directions for further research which we pursue through a differentiated replication of the Dirichlet stochastic model. We demonstrate predictable behavioral patterns of purchase and loyalty in two distinct industrial markets for components used in critical surgical procedures. This differentiated replication supports the argument for the use of stochastic modeling techniques in industrial marketing management, not only as a management tool but also as a lens to inform and focus research towards integrated theories of the evolution of market structure and network relationships

Check List and Basic Guide to the Administration of Decedents\u27 Estates under New Article 93, Revised to July 1, 1973, Together with a Summary of Pertinent 1973 Session Laws of the General Assembly of Maryland and an Appendix of Forms

In 1969, the Maryland General Assembly enacted a new testamentary Law for the state which is, in effect, a modified version qf the Uniform Probate Code and is now codified as Article 93 of the Maryland Annotated Code. Generally acclaimed as one of the most significant acts of legislation in recent Maryland history, the new Article 93 reflects an accommodation of a few radical changes within the time honored body of estate law. Certain probate procedures, in particular, have undergone significant revision. The following Check List and Basic Guide to the Administration of Decedents\u27 Estates represents one institution\u27s efforts at providing a road map for compliance with the procedural requirements for probate and administration under the new law. Recognizing the intrinsic value of this document, both for the young lawyer and for the more experienced members of the practicing bar who may not be familiar with the new procedures, the Board of Editors decided that it was deserving of general distribution. For their kind permission to reprint the Check List and Guide, the Board is grateful to Mr. James G. McCabe and the Trust Department of Maryland National Bank

Check List and Basic Guide to the Administration of Decedents\u27 Estates under New Article 93, Revised to July 1, 1973, Together with a Summary of Pertinent 1973 Session Laws of the General Assembly of Maryland and an Appendix of Forms

In 1969, the Maryland General Assembly enacted a new testamentary Law for the state which is, in effect, a modified version qf the Uniform Probate Code and is now codified as Article 93 of the Maryland Annotated Code. Generally acclaimed as one of the most significant acts of legislation in recent Maryland history, the new Article 93 reflects an accommodation of a few radical changes within the time honored body of estate law. Certain probate procedures, in particular, have undergone significant revision. The following Check List and Basic Guide to the Administration of Decedents\u27 Estates represents one institution\u27s efforts at providing a road map for compliance with the procedural requirements for probate and administration under the new law. Recognizing the intrinsic value of this document, both for the young lawyer and for the more experienced members of the practicing bar who may not be familiar with the new procedures, the Board of Editors decided that it was deserving of general distribution. For their kind permission to reprint the Check List and Guide, the Board is grateful to Mr. James G. McCabe and the Trust Department of Maryland National Bank

Cosmic microwave background multipole alignments in slab topologies

Several analyses of the microwave sky maps from the Wilkinson Microwave Anisotropy Probe (WMAP) have drawn attention to alignments amongst the low-order multipoles. Amongst the various possible explanations, an effect of cosmic topology has been invoked by several authors. We focus on an alignment of the first four multipoles (\ell = 2 to 5) found by Land and Magueijo (2005), and investigate the distribution of their alignment statistic for a set of simulated cosmic microwave background maps for cosmologies with slab-like topology. We find that this topology does offer a modest increase in the probability of the observed value, but that even for the smallest topology considered the probability of the observed value remains below one percent.Comment: 6 pages RevTex with 6 figures included. Minor changes to match version accepted as Physical Review D Rapid Communicatio

Outlook for tuberculosis elimination in California: An individual-based stochastic model.

RationaleAs part of the End TB Strategy, the World Health Organization calls for low-tuberculosis (TB) incidence settings to achieve pre-elimination (<10 cases per million) and elimination (<1 case per million) by 2035 and 2050, respectively. These targets require testing and treatment for latent tuberculosis infection (LTBI).ObjectivesTo estimate the ability and costs of testing and treatment for LTBI to reach pre-elimination and elimination targets in California.MethodsWe created an individual-based epidemic model of TB, calibrated to historical cases. We evaluated the effects of increased testing (QuantiFERON-TB Gold) and treatment (three months of isoniazid and rifapentine). We analyzed four test and treat targeting strategies: (1) individuals with medical risk factors (MRF), (2) non-USB, (3) both non-USB and MRF, and (4) all Californians. For each strategy, we estimated the effects of increasing test and treat by a factor of 2, 4, or 10 from the base case. We estimated the number of TB cases occurring and prevented, and net and incremental costs from 2017 to 2065 in 2015 U.S. dollars. Efficacy, costs, adverse events, and treatment dropout were estimated from published data. We estimated the cost per case averted and per quality-adjusted life year (QALY) gained.Measurements and main resultsIn the base case, 106,000 TB cases are predicted to 2065. Pre-elimination was achieved by 2065 in three scenarios: a 10-fold increase in the non-USB and persons with MRF (by 2052), and 4- or 10-fold increase in all Californians (by 2058 and 2035, respectively). TB elimination was not achieved by any intervention scenario. The most aggressive strategy, 10-fold in all Californians, achieved a case rate of 8 (95% UI 4-16) per million by 2050. Of scenarios that reached pre-elimination, the incremental net cost was $20 billion (non-USB and MRF) to$48 billion. These had an incremental cost per QALY of $657,000 to$3.1 million. A more efficient but somewhat less effective single-lifetime test strategy reached as low as $80,000 per QALY.ConclusionsSubstantial gains can be made in TB control in coming years by scaling-up current testing and treatment in non-USB and those with medical risks

Predictors of outcomes in mild pulmonary hypertension according to 2022 ESC/ERS Guidelines: the EVIDENCE-PAH UK study

BACKGROUND AND AIMS: Interventional studies in pulmonary arterial hypertension completed to date have shown to be effective in symptomatic patients with significantly elevated mean pulmonary artery pressure (mPAP) (≥25 mmHg) and pulmonary vascular resistance (PVR) > 3 Wood Unit (WU). However, in health the mPAP does not exceed 20 mmHg and PVR is 2 WU or lower, at rest. The ESC/ERS guidelines have recently been updated to reflect this. There is limited published data on the nature of these newly defined populations (mPAP 21-24 mmHg and PVR >2-≤3 WU) and the role of comorbidity in determining their natural history. With the change in guidelines, there is a need to understand this population and the impact of the ESC/ERS guidelines in greater detail. METHODS: A retrospective nationwide evaluation of the role of pulmonary haemodynamics and comorbidity in predicting survival among patients referred to the UK pulmonary hypertension (PH) centres between 2009 and 2017. In total, 2929 patients were included in the study. Patients were stratified by mPAP ( 2-≤3 WU, and >3 WU), with 968 (33.0%) in the mPAP 2-≤3WU) was lower than among those with normal pressures (mPAP <21 mmHg) and normal PVR (PVR ≤ 2WU) independent of comorbid lung and heart disease [hazard ratio (HR) 1.36, 95% confidence interval (CI) 1.14-1.61, P = .0004 for mPAP vs. HR 1.28, 95% CI 1.10-1.49, P = .0012 for PVR]. Among patients with mildly elevated mPAP, a mildly elevated PVR remained an independent predictor of survival when adjusted for comorbid lung and heart disease (HR 1.33, 95% CI 1.01-1.75, P = .042 vs. HR 1.4, 95% CI 1.06-1.86, P = .019). 68.2% of patients with a mPAP 21-24 mmHg had evidence of underlying heart or lung disease. Patients with mildly abnormal haemodynamics were not more symptomatic than patients with normal haemodynamics. Excluding patients with heart and lung disease, connective tissue disease was associated with a poorer survival among those with PH. In this subpopulation evaluating those with a mPAP of 21-24 mmHg, survival curves only diverged after 5 years. CONCLUSIONS: This study supports the change in diagnostic category of the ESC/ERS guidelines in a PH population. The newly included patients have an increased mortality independent of significant lung or heart disease. The majority of patients in this new category have underlying heart or lung disease rather than an isolated pulmonary vasculopathy. Mortality is higher if comorbidity is present. Rigorous phenotyping will be pivotal to determine which patients are at risk of progressive vasculopathic disease and in whom surveillance and recruitment to studies may be of benefit. This study provides an insight into the population defined by the new guidelines

Ventriculo-arterial coupling detects occult RV dysfunction in chronic thromboembolic pulmonary vascular disease.

Chronic thromboembolic disease (CTED) is suboptimally defined by a mean pulmonary artery pressure (mPAP)  0.68 and Ees/Ea < 0.68 subgroups demonstrated constant RV stroke work but lower stroke volume (87.7 ± 22.1 vs. 60.1 ± 16.3 mL respectively, P = 0.006) and higher end-systolic pressure (36.7 ± 11.6 vs. 68.1 ± 16.7 mmHg respectively, P < 0.001). Lower Ees/Ea in CTED also correlated with reduced exercise ventilatory efficiency. Low Ees/Ea aligns with features of RV maladaptation in CTED both at rest and on exercise. Characterization of Ees/Ea in CTED may allow for better identification of occult RV dysfunction