3,221 research outputs found

    What is a categorical model of arrows?

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    We investigate what the correct categorical formulation of Hughes’ Arrows should be. It has long been folklore that Arrows, a functional programming construct, and Freyd categories, a categorical notion due to Power, Robinson and Thielecke, are somehow equivalent. In this paper, we show that the situation is more subtle. By considering Arrows wholly within the base category we derive two alternative formulations of Freyd category that are equivalent to Arrows—enriched Freyd categories and indexed Freyd categories. By imposing a further condition, we characterise those indexed Freyd categories that are isomorphic to Freyd categories. The key differentiating point is the number of inputs available to a computation and the structure available on them, where structured input is modelled using comonads

    Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use

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    The use of testosterone replacement therapy (TRT) for hypogonadism continues to rise, particularly in younger men who may wish to remain fertile. Concurrently, awareness of a more pervasive use of anabolic-androgenic steroids (AAS) within the general population has been appreciated. Both TRT and AAS can suppress the hypothalamic-pituitary-gonadal (HPG) axis resulting in diminution of spermatogenesis. Therefore, it is important that clinicians recognize previous TRT or AAS use in patients presenting for infertility treatment. Cessation of TRT or AAS use may result in spontaneous recovery of normal spermatogenesis in a reasonable number of patients if allowed sufficient time for recovery. However, some patients may not recover normal spermatogenesis or tolerate waiting for spontaneous recovery. In such cases, clinicians must be aware of the pathophysiologic derangements of the HPG axis related to TRT or AAS use and the pharmacologic agents available to reverse them. The available agents include injectable gonadotropins, selective estrogen receptor modulators, and aromatase inhibitors, but their off-label use is poorly described in the literature, potentially creating a knowledge gap for the clinician. Reviewing their use clinically for the treatment of hypogonadotropic hypogonadism and other HPG axis abnormalities can familiarize the clinician with the manner in which they can be used to recover spermatogenesis after TRT or AAS use

    Co-creating an Open Government Data Driven Public Service: The Case of Chicago’s Food Inspection Forecasting Model

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    Large amounts of Open Government Data (OGD) have become available and co-created public services have started to emerge, but there is only limited empirical material available on co-created OGD-driven public services. To address this shortcoming and explore the concept of co-created OGD-driven public services the authors conducted an exploratory case study. The case study explored Chicago’s use of OGD in the co-creation of a predictive analytics model that forecasts critical safety violations at food serving establishments. The results of this exploratory work allowed for new insights to be gained on co-created OGD-driven public services and led to the identification of six factors that seem to play a key role in allowing for a OGD-driven public service to be co-created. The results of the initial work also provide valuable new information that can be used to aid in the development and improvement of the authors’ conceptual model for understanding co-created OGD-driven public service

    Is Government Welfare Able to Change? Analysing Efforts to Co-create an Improved Social Welfare System through Taking Advantage of a Collaborative Economy

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    Welfare sectors across the world are facing the need to balance the contrast between economic pressures due to demographic changes and peoples’ rising expectations of receiving services that are transparent; timely and tailored to citizens’ habits and needs. This means that governments are pressured to look for new ways to deliver public services. This article looks at two co-created peer-to-peer platforms that are engaged in delivering public services in the welfare sector, Helpific and Caremate, and their development and role in the Estonian welfare sector. These platforms appear to hold substantial potential for changing the current system of delivering public services, however they have not yet managed to acquire the anticipated level of success. By examining these two cases, it is proposed that the room and support for developing new solutions, using experience in the field and overcoming the digital divide must be assured in order to make changes in government welfare possible
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