Analysis of laboratory and field measurements of directionally spread nonlinear ocean waves

Surface gravity waves exist in the oceans as multi-directional nonlinear phenomena. Understanding how these two properties interact is intrinsically important in itself. Furthermore, an understanding of this relationship may be used to gain insight into other oceanic phenomena. This thesis first describes an experimental investigation into the relationship between directionality and non-linearity (Part I). This relationship was then used as a tool to estimate the directional spreading of field data (Part II). Experiments have been conducted in which directionally spread focused wave groups were created in a wave tank. The relationship between the degree of directional spreading and the second-order bound harmonics of the wave groups was examined, in particular the formation of a `set-up'. These measurements were then compared to predictions from second-order theories, finding good agreement. The two-dimensional structure of the bound waves was explored giving new insight into the underlying physics. Experiments were then carried out for directionally spread crossing wave groups. It is believed that the crossing of two sufficiently separated wave groups may be the cause of an anomalous set-up in the second-order bound waves observed for some extreme and potentially freak waves. This set-up is reproduced experimentally. Again, the results of these test agreed very well when compared to second-order theory. The insight gained from the foregoing experiments was then utilised in the analysis of field data. A method, which requires only a single measurement to estimate the observed degree of directional spreading, was applied to a large dataset of field measurements from the North Alwyn platform in the North Sea. This method was then compared to conventional approaches, which require multiple concurrent measurements. The method that requires only a single measurement was shown to be effective, and presents a promising approach to gaining additional insight about the directional spreading of point observations

Experimental Observation of Modulational Instability in Crossing Surface Gravity Wavetrains

The coupled nonlinear Schrödinger equation (CNLSE) is a wave envelope evolution equation applicable to two crossing, narrow-banded wave systems. Modulational instability (MI), a feature of the nonlinear Schrödinger wave equation, is characterized (to first order) by an exponential growth of sideband components and the formation of distinct wave pulses, often containing extreme waves. Linear stability analysis of the CNLSE shows the effect of crossing angle, θ, on MI, and reveals instabilities between 0◦ < θ < 35◦, 46◦ < θ < 143◦, and 145◦ < θ < 180◦. Herein, the modulational stability of crossing wavetrains seeded with symmetrical sidebands is determined experimentally from tests in a circular wave basin. Experiments were carried out at 12 crossing angles between 0◦ ≤ θ ≤ 88◦, and strong unidirectional sideband growth was observed. This growth reduced significantly at angles beyond θ ≈ 20◦, reaching complete stability at θ = 30–40◦. We find satisfactory agreement between numerical predictions (using a time-marching CNLSE solver) and experimental measurements for all crossing angles

A review on the interactions between the tumour microenvironment and androgen receptor signaling in prostate cancer

Prostate cancer growth is controlled by androgen receptor signaling via both androgen-dependent and androgen-independent pathways. Furthermore, the prostate is an immune competent organ with inflammatory changes both within the systemic and local environment contributing to the reprogramming of the prostatic epithelium with consistently elevated lymphocyte infiltration and pro-inflammatory cytokines being found in prostate cancer. The crosstalk between the tumour microenvironment and androgen receptor signaling is complex with both pro-tumorigenic and anti-tumourigenic roles observed. However, despite an increase in immune checkpoint inhibitors and inflammatory signaling blockades available for a range of cancer types, we are yet to see substantial progress in the treatment of prostate cancer. Therefore, this review aims to summarize the tumour microenvironment and its impact on androgen receptor signaling in prostate cancer