A wearable, low-power, health-monitoring instrumentation based on a programmable system-on-chip

International audienceImprovement in quality and efficiency of health and medicine, at home and in hospital, has become of paramount importance. The solution of this problem would require the continuous monitoring of several key patient parameters, including the assessment of autonomic nervous system (ANS) activity using non-invasive sensors, providing information for emotional, sensorial, cognitive and physiological analysis of the patient. Recent advances in embedded systems, microelectronics, sensors and wireless networking enable the design of wearable systems capable of such advanced health monitoring. The subject of this article is an ambulatory system comprising a small wrist device connected to several sensors for the detection of the autonomic nervous system activity. It affords monitoring of skin resistance, skin temperature and heart activity. It is also capable of recording the data on a removable media or sending it to computer via a wireless communication. The wrist device is based on a programmable system-on-chip (PSoC) from Cypress: PSoCs are mixed-signal arrays, with dynamic, configurable digital and analogical blocks and an 8-bit microcontroller unit (MCU) core on a single chip. In this paper we present first of all the hardware and software architecture of the device, and then results obtained from initial experiments

A wireless, low-power, smart sensor of cardiac activity for clinical remote monitoring

International audienceThis paper presents the development of a wireless wearable sensor for the continuous, long-term monitoring of cardiac activity. Heart rate assessment, as well as heart rate variability parameters are computed in real time directly on the sensor, thus only a few parameters are sent via wireless communication for power saving. Hardware and software methods for heart beat detection and variability calculation are described and preliminary tests for the evaluation of the sensor are presented. With an autonomy of 48 hours of active measurement and a Bluetooth Low Energy radio technology, this sensor will form a part of a wireless body network for the remote mobile monitoring of vital signals in clinical applications requiring automated collection of health data from multiple patients

Temperature Measurement of Server Room

In this project we will be developing a system to help monitor temperature in data centers. This system will include software and a circuit to route resistive temperature devices (RTDs) (Figure 1) to a microchip which will output their readings as data. The system should be able to connect with 64 RTDs, read the temperatures from them, and make the data accessible over a network. This system could also be used in other situations besides data centers. The user would decide where to place the devices and how to use the temperature data. This system will allow more RTDs to be monitored by the microchip than can currently be monitored. Currently one of the microchips can control 8 RTDs in a daisy chain configuration. The system will also allow the data to be accessed over a network. With this capability the user can check on the temperatures in the data center remotely. If successful, this project will give data center managers the capability to monitor for hot spots more easily and thoroughly. The system will be composed of the circuit which routes the RTDs to the chip and the software on the computer to control everything. To design the circuit block, diagrams will be used to represent the components and their functions. More detailed models will be made using circuit design software (Figure 2). Block diagrams will also be used to lay out the functions of the software. The software will need to send the current RTD routing data to the circuit, translate the data from the microchip, store the data, and supply the data in response to queries on the network. The system will use category 5 Ethernet cables for all connections, and the MAX31865 chip to read the RTDs. A raspberry pi device will be used as the controlling computer and will be programmed using the python programming language.https://scholarscompass.vcu.edu/capstone/1037/thumbnail.jp

Effect of Processing on Morphology of Hydroxyapatites: Bioactive Glasses and Crystalline Composites

Recent studies on multinary oxides for applications as laser hosts and high dielectric capacitors have shown that processing at high temperature provides glassy or crystalline materials based on thermal treatments and cooling rates. Since hydroxyapatites are now subject of great interests due to their bioactivity, interest in producing soft and hard materials with glassy and crystalline nature by processing parameters has become very important. Crystalline materials by using Bridgman, Czochralski and flux growth methods are costly and require huge investment. We have observed that even low temperature solidification in organic flux produced oriented fibers. This organic treated material has different characteristics than in situ oxide materials prepared by sintering and grain growth. Examples of phosphate and silicate-based systems will be presented to demonstrate soft and hard materials. Effect of TiO2 and other hardening elements will be also reported

A Group M Consensus Envelope Glycoprotein Induces Antibodies That Neutralize Subsets of Subtype B and C HIV-1 Primary Viruses

HIV-1 subtype C is the most common HIV-1 group M subtype in Africa and many parts of Asia. However, to date HIV-1 vaccine candidate immunogens have not induced potent and broadly neutralizing antibodies against subtype C primary isolates. We have used a centralized gene strategy to address HIV-1 diversity, and generated a group M consensus envelope gene with shortened consensus variable loops (CON-S) for comparative studies with wildtype (WT) Env immunogens. Our results indicate that the consensus HIV-1 group M CON-S Env elicited cross-subtype neutralizing antibodies of similar or greater breadth and titer than the WT Envs tested, indicating the utility of a centralized gene strategy. Our study also shows the feasibility of iterative improvements in Env immunogenicity by rational design of centralized genes

Early Navigation Performance of the OSIRIS-REx Approach to Bennu

The New Frontiers-class OSIRIS-REx (Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer) mission is the first American endeavor to return a sample from an asteroid. In preparation for retrieving the sample, OSIRIS-REx is conducting a campaign of challenging proximity-operations maneuvers and scientific observations, bringing the spacecraft closer and closer to the surface of near-Earth asteroid (101955) Bennu. Ultimately, the spacecraft will enter a 900-meter-radius orbit about Bennu and conduct a series of reconnaissance flybys of candidate sample sites before being guided into contact with the surface for the Touch and Go sample collection event. Between August and December 2018, the OSIRIS-REx team acquired the first optical observations of Bennu and used them for navigation. We conducted a series of maneuvers with the main engine, Trajectory Correction Maneuver, and Attitude Control System thruster sets to slow the OSIRIS-REx approach to Bennu and achieve rendezvous on December 3, 2018. This paper describes the trajectory design, navigation conops, and key navigation results from the Approach phase of the OSIRIS-REx mission