879 research outputs found
The construction technology evolution with the purpose of energy consumptions reduction and safety increase in wooden house-building in Italy
The ms 6.9, 1980 irpinia earthquake from the basement to the surface: a review of tectonic geomorphology and geophysical constraints, and new data on postseismic deformation
The MS 6.9, 1980 Irpinia earthquake occurred in the southern Apennines, a fold and thrust belt that has been undergoing post-orogenic extension since ca. 400 kyr. The strongly anisotropic structure of fold and thrust belts like the Apennines, including late-orogenic low-angle normal faults and inherited Mesozoic extensional features besides gently dipping thrusts, result in a complex, overall layered architecture of the orogenic edifice. Effective decoupling between deep and shallow structural levels of this mountain belt is related to the strong rheological contrast produced by a fluid-saturated, shale-dominated mélange zone interposed between buried autochthonous carbonates—continuous with those exposed in the foreland to the east—and the allochthonous units. The presence of fluid reservoirs below the mélange zone is shown by a high VP /VS ratio—which is a proxy for densely fractured fluid-saturated crustal volumes—recorded by seismic tomography within the buried autochthonous carbonates and the top part of the underlying basement. These crustal volumes, in which background seismicity is remarkably concentrated, are fed by fluids migrating along the major active faults. High pore fluid pressures, decreasing the yield stress, are recorded by low stress-drop values associated with the earthquakes. On the other hand, the mountain belt is characterized by substantial gas flow to the surface, recorded as both distributed soil gas emissions and vigorous gas vents. The accumulation of CO2-brine within a reservoir located at hypocentral depths beneath the Irpinia region is not only interpreted to control a multiyear cyclic behavior of microseismicity, but could also play a role in ground motions detected by space-based geodetic measurements in the postseismic period. The analysis carried out in this study of persistent scatterer interferometry synthetic aperture radar (PS-InSAR) data, covering a timespan ranging from 12 to 30 years after the 1980 mainshock, points out that ground deformation has affected the Irpinia earthquake epicentral area in the last decades. These ground motions could be a result of postseismic afterslip, which is well known to occur over years or even decades after a large mainshock such as the 23 November 1980, MS 6.9 earthquake due to cycles of CO2-brine accumulation at depth and its subsequent release by Mw ≥ 3.5 earthquakes, or most likely by a combination of both. Postseismic afterslip controls geomorphology, topography, and surface deformation in seismically active areas such as that of the present study, characterized by ~M 7 earthquakes. Yet, this process has been largely overlooked in the case of the 1980 Irpinia earthquake, and one of the main aims of this study is to fill such the substantial gap of knowledge for the epicentral area of some of the most destructive earthquakes that have ever occurred in Italy
Direct fabrication through electron beam melting technology of custom cranial implants designed in a phantom based haptic
Repairing critical human skull injuries requires the production and use of customized cranial implants and involves the integration of computer aided design and manufacturing (CAD and CAM). The main causes for large cranial defects are trauma, cranial tumors, infected craniotomy bone flaps and external neurosurgical decompression. The success of reconstructive cranial surgery depends upon: the preoperative evaluation of the defect, the design and manufacturing of the implant, and the skill of the operating surgeon. Cranial implant design is usually carried out manually using CAD although this process is very time-consuming and the quality of the end product depends wholly upon the skill of the operator. This paper presents an alternative automated method for the design of custom-made cranial plates in a PHANToM \uae-based haptic environment, and their direct fabrication in biocompatible metal using electron beam melting (EBM) technology
Evaluation of 3D Technologies In Dentistry
Quality of service, in terms of improvement in patient satisfaction, is an increasingly important objective in all medical fields, and is especially imperative in orthodontics due to the high numbers of patients treated. Information technology can provide a meaningful contribution to bettering treatment processes, and we maintain that systems such as CAD, CAM and CAE, although initially conceived for industrial purposes, should be evaluated, studied and customized with a view to use in medicine. The present study aims to evaluate Reverse Engineering (RE) and Rapid Prototyping (RP) in order to define an ideal chain of advanced technological solutions to support the critical processes of orthodontic activity
5d-5f Electric-multipole Transitions in Uranium Dioxide Probed by Non-resonant Inelastic X-ray Scattering
Non-resonant inelastic x ray scattering (NIXS) experiments have been
performed to probe the 5d-5f electronic transitions at the uranium O(4,5)
absorption edges in uranium dioxide. For small values of the scattering vector
q, the spectra are dominated by dipole-allowed transitions encapsulated within
the giant resonance, whereas for higher values of q the multipolar transitions
of rank 3 and 5 give rise to strong and well-defined multiplet structure in the
pre-edge region. The origin of the observed non-dipole multiplet structures is
explained on the basis of many-electron atomic spectral calculations. The
results obtained demonstrate the high potential of NIXS as a bulk-sensitive
technique for the characterization of the electronic properties of actinide
materials.Comment: Submitted to Physical Review Letters on 31 December 200
Cell-surface binding domains from Clostridium cellulovorans can be used for surface display of cellulosomal scaffoldins in Lactococcus lactis
Engineering microbial strains combining efficient lignocellulose metabolization and high-value chemical production is a cutting-edge strategy towards cost-sustainable 2nd generation biorefining. Here, protein components of the Clostridium cellulovorans cellulosome were introduced in Lactococcus lactis IL1403, one of the most efficient lactic acid producers but unable to directly ferment cellulose. Cellulosomes are protein complexes with high cellulose depolymerization activity whose synergistic action is supported by scaffolding protein(s) (i.e., scaffoldins). Scaffoldins are involved in bringing enzymes close to each other and often anchor the cellulosome to the cell surface. In this study, three synthetic scaffoldins were engineered by using domains derived from the main scaffoldin CbpA and the Endoglucanase E (EngE) of the C. cellulovorans cellulosome. Special focus was on CbpA X2 and EngE S-layer homology (SLH) domains possibly involved in cell-surface anchoring. The recombinant scaffoldins were successfully introduced in and secreted by L. lactis. Among them, only that carrying the three EngE SLH modules was able to bind to the L. lactis surface although these domains lack the conserved TRAE motif thought to mediate binding with secondary cell wall polysaccharides. The synthetic scaffoldins engineered in this study could serve for assembly of secreted or surface-displayed designer cellulosomes in L. lactis
Cell-surface binding domains from Clostridium cellulovorans can be used for surface display of cellulosomal scaffoldins in Lactococcus lactis
Prolonged changes in hepatic mitochondrial activity and insulin sensitivity by high fructose intake in adolescent rats
Persistence of damage induced by unhealthy diets during youth has been little addressed. Therefore, we investigated the impact of a short‐term fructose‐rich diet on liver metabolic activity in adolescent rats and the putative persistence of alterations after removing fructose from the diet. Adolescent rats were fed a fructose‐rich diet for three weeks and then switched to a control diet for further three weeks. Body composition and energy balance were not affected by fructose‐rich diet, while increased body lipids and lipid gain were found after the rescue period. Switching to a control diet reversed the upregulation of plasma fructose, uric acid, lipocalin, and haptoglobin, while plasma triglycerides, alanine aminotransferase, lipopolysaccharide, and tumor necrosis factor alpha remained higher. Hepatic steatosis and ceramide were increased by fructose‐rich diet, but reversed by returning to a control diet, while altered hepatic response to insulin persisted. Liver fatty acid synthase and stearoyl‐CoA desaturase (SCD) activities were upregulated by fructose‐rich diet, and SCD activity remained higher after returning to the control diet. Fructose‐induced upregulation of complex II‐driven mitochondrial respiration, peroxisome proliferator‐activated receptor‐gamma coactivator 1 alpha, and peroxisome proliferator activated receptor α also persisted after switching to control diet. In conclusion, our results show prolonged fructose‐induced dysregulation of liver metabolic activity
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