Transient Effects of Self-adjustment of Pressure Reducing Valves

AbstractPressure control strategy through Pressure Reducing Valves (PRV) has been deeply investigated as management strategy, aimed at water leakages reduction avoiding very expensive pipe replacement programs. On the contrary, few experimental data are available in literature, with regard to PRV transient behavior in terms of its response to incoming pressure waves, as well as the time required for achieving the pressure set point. In this paper, the results of some experimental tests are presented. The PRV is installed in a single high density polyethylene pipe and transients are generated by operating the downstream end valve. Two types of tests are considered: a partial valve closure and opening simulating a water demand decrease and increase, respectively. The analysis of the experimental pressure traces points out the valuable effects of the PRV on transient characteristics with respect to the case of a partially closed in-line valve with a constant opening degree

Long-Term Efficacy of Intensive Zoledronate Therapy and Predictors of Retreatment in Paget’s Disease of Bone

Despite the current debate on the best therapeutic approach, i.e. symptomatic vs intensive strategy, one zoledronate (Zol) infusion is effective in most patients with Paget’s disease of bone (PDB), whereas few need retreatment, whose predictors are not well established. We aimed to evaluate long-term efficacy of intensive Zol therapy and predictors of retreatment in PDB. Pagetic complications, clinical and biochemical response to Zol together with frequency of retreatment were retrospectively assessed in forty-seven PDB patients (age, mean ± SD: 72.5 ± 8.9 years, M/F: 24/23; symptomatic/asymptomatic: 16/31). Statistical analysis for retreatment prediction were based on Mann–Whitney U test, Pearson’s Χ2 and ROC curve analysis. During seven-year follow-up, all patients achieved pain relief and only one underwent arthroplasty. Bone alkaline phosphatase (BAP) detected three non-responder (6%) and six relapsing (13%) patients needing retreatment. Retreated patients had less old age (66.1 ± 11.2 vs 74.0 ± 7.7 years), higher frequency of polyostotic disease (78% vs 40%) and higher baseline (96.5 ± 24.8 vs 44.9 ± 27.7 mcg/l) and post-Zol nadir BAP levels (24.7 ± 24.1 vs 8.1 ± 4.1 mcg/l) than patients treated once (p < 0.05 for all comparisons). In multivariate analysis both serum baseline and post-Zol nadir BAP significantly predicted retreatment (OR 1.09, 95%CI 1.01–1.17 and 1.29, 1.03–1.62, respectively), with ROC curve analysis showing the greatest accuracies for threshold values of 75.6 and 9.9 mcg/l (sensitivity 88 and 90%, specificity 94 and 86%, AUC 0.92 and 0.93, respectively). Our data in mostly asymptomatic, metabolically active PDB patients treated with intensive Zol therapy show a negligible incidence of pagetic complications and long-term optimal disease control, with BAP being the best predictor of retreatment

There is a limit to your openness: Mental illness stigma mediates effects of individual traits on preference for psychiatry specialty

Objective: The widening gap between the need for mental health professionals and the low percentages of medical students pursuing a psychiatric career urges an examination of how individual traits, stigma attitudes, and related intended behaviors interact to better explain the variance in preferences for psychiatry as a specialty choice. Methods: Participants were second-year, preclinical medical students at Bologna University, Italy. The study consisted in completion of an online questionnaire evaluating preferences for the psychiatry specialty (one single item and a scenario-based response), personality traits (the Big Five Questionnaire), attitudes (Mental Illness for Clinicians\u2019 Attitude scale), behaviors (Reported and Intended Behavior Scale), and fears toward mental illness (questionnaire created ad hoc). Sociodemographic data were also collected. Results: A total of 284 medical students [58.8% female, mean (SD) age 20.47 \ub1 1.90] completed the questionnaire. Preference for the psychiatry specialty was significantly and positively associated with openness to experience and negatively related with Mental Illness for Clinicians\u2019 Attitude scale and Reported and Intended Behavior Scale. The full-mediation model provided good indices explaining 18% of the variance. Mental illness stigma was strongly and negatively associated with both openness to experience and preference for psychiatry, and the mediation results evidenced a positive and significant effect. Conclusions: Mental illness stigma influences medical students\u2019 choice of psychiatry as a specialty, accounting for the effects of the openness to experience trait. Stigma awareness and reduction programs should be introduced as early as possible in medical education

CDI/THREDDS interoperability in the SeaDataNet framework

Abstract. SeaDataNet is an EU funded project aiming to create and operate a pan-European, marine data infrastructure for managing the large and diverse datasets (i.e. temperature, salinity current, sea level, chemical, physical and biological properties) collected by the oceanographic fleets and the new automatic observation systems. In order to make the SeaDataNet system compliant with the INSPIRE Implementing Rules for discovery service, an ISO 19139 encoding of the SeaDataNet Common Data Index (CDI) metadata model was defined. Moreover, the problem of heterogeneous data sources has been addressed. In fact, a widely used system of SeaDataNet partners and oceanographic-marine community is THREDDS/OPeNDAP; this raises up the problem of federating into SeaDataNet framework THREDDS/OPeNDAP systems as well. In this paper we describe an interoperability framework to access resources (i.e. data and services) that are available through CDI and THREDDS/OPeNDAP services. The proposed solution implements a common catalog interface to discover and access the two heterogeneous resources in a common way. This catalog service is fully distributed and implements international standards as far as geospatial information discovery and query are concerned. The developed solution is called GI-cat and was experimented in the framework of the SeaDataNet European project