7 research outputs found
Unstable fields in Kerr spacetimes
We show that both the interior region of a Kerr black
hole and the Kerr naked singularity admit unstable solutions of the
Teukolsky equation for any value of the spin weight. For every harmonic number
there is at least one axially symmetric mode that grows exponentially in time
and decays properly in the radial directions. These can be used as Debye
potentials to generate solutions for the scalar, Weyl spinor, Maxwell and
linearized gravity field equations on these backgrounds, satisfying appropriate
spatial boundary conditions and growing exponentially in time, as shown in
detail for the Maxwell case. It is suggested that the existence of the unstable
modes is related to the so called "time machine" region, where the axial
Killing vector field is time-like, and the Teukolsky equation, restricted to
axially symmetric fields, changes its character from hyperbolic to elliptic
Gravastar energy conditions revisited
We consider the gravastar model where the vacuum phase transition between the
de Sitter interior and the Schwarzschild or Schwarzschild-de Sitter exterior
geometries takes place at a single spherical delta-shell. We derive sharp
analytic bounds on the surface compactness (2m/r) that follow from the
requirement that the dominant energy condition (DEC) holds at the shell. In the
case of Schwarzschild exterior, the highest surface compactness is achieved
with the stiff shell in the limit of vanishing (dark) energy density in the
interior. In the case of Schwarzschild-de Sitter exterior, in addition to the
gravastar configurations with the shell under surface pressure, gravastar
configurations with vanishing shell pressure (dust shells), as well as
configurations with the shell under surface tension, are allowed by the DEC.
Respective bounds on the surface compactness are derived for all cases. We also
consider the speed of sound on the shell as derived from the requirement that
the shell is stable against the radial perturbations. The causality requirement
(sound speed not exceeding that of light) further restricts the space of
allowed gravastar configurations.Comment: LaTeX/IOP-style, 16 pages, 2 figures, changes wrt v1: motivation for
eq. (6) clarified, several referecnes added (to appear in Class. Quantum
Grav.
Edoxaban versus warfarin in patients with atrial fibrillation
Contains fulltext :
125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)