1,574 research outputs found
Endotaxial Si nanolines in Si(001):H
We present a detailed study of the structural and electronic properties of a
self-assembled silicon nanoline embedded in the H-terminated silicon (001)
surface, known as the Haiku stripe. The nanoline is a perfectly straight and
defect free endotaxial structure of huge aspect ratio; it can grow micrometre
long at a constant width of exactly four Si dimers (1.54nm). Another remarkable
property is its capacity to be exposed to air without suffering any
degradation. The nanoline grows independently of any step edges at tunable
densities, from isolated nanolines to a dense array of nanolines. In addition
to these unique structural characteristics, scanning tunnelling microscopy and
density functional theory reveal a one-dimensional state confined along the
Haiku core. This nanoline is a promising candidate for the long sought after
electronic solid-state one-dimensional model system to explore the fascinating
quantum properties emerging in such reduced dimensionality.Comment: 8 pages, 6 figure
Langevin equation for the extended Rayleigh model with an asymmetric bath
In this paper a one-dimensional model of two infinite gases separated by a
movable heavy piston is considered. The non-linear Langevin equation for the
motion of the piston is derived from first principles for the case when the
thermodynamic parameters and/or the molecular masses of gas particles on left
and right sides of the piston are different. Microscopic expressions involving
time correlation functions of the force between bath particles and the piston
are obtained for all parameters appearing in the non-linear Langevin equation.
It is demonstrated that the equation has stationary solutions corresponding to
directional fluctuation-induced drift in the absence of systematic forces. In
the case of ideal gases interacting with the piston via a quadratic repulsive
potential, the model is exactly solvable and explicit expressions for the
kinetic coefficients in the non-linear Langevin equation are derived. The
transient solution of the non-linear Langevin equation is analyzed
perturbatively and it is demonstrated that previously obtained results for
systems with the hard-wall interaction are recovered.Comment: 10 pages. To appear in Phys. Rev.
One dimensional Si-in-Si(001) template for single-atom wire growth
Single atom metallic wires of arbitrary length are of immense technological
and scientific interest. We describe a novel silicon-only template enabling the
self-organised growth of isolated micrometer long surface and subsurface
single-atom chains. It consists of a one dimensional, defect-free
reconstruction - the Haiku core, here revealed for the first time in details -
self-assembled on hydrogenated Si(001) terraces, independent of any step edges.
We discuss the potential of this Si-in-Si template as an appealing alternative
to vicinal surfaces for nanoscale patterning.Comment: 3 pages, 2 figure
Phase diagram and critical properties in the Polyakov--Nambu--Jona-Lasinio model
We investigate the phase diagram of the so-called
Polyakov--Nambu--Jona-Lasinio model at finite temperature and nonzero chemical
potential with three quark flavours. Chiral and deconfinement phase transitions
are discussed, and the relevant order-like parameters are analyzed. The results
are compared with simple thermodynamic expectations and lattice data. A special
attention is payed to the critical end point: as the strength of the
flavour-mixing interaction becomes weaker, the critical end point moves to low
temperatures and can even disappear.Comment: Talk given at the 9th International Conference on Quark Confinement
and the Hadron Spectrum - QCHS IX, Madrid, Spain, 30 August - September 201
Population of isomers in decay of the giant dipole resonance
The value of an isomeric ratio (IR) in N=81 isotones (Ba, Ce,
Nd and Sm) is studied by means of the ( reaction.
This quantity measures a probability to populate the isomeric state in respect
to the ground state population. In ( reactions, the giant dipole
resonance (GDR) is excited and after its decay by a neutron emission, the
nucleus has an excitation energy of a few MeV. The forthcoming decay
by direct or cascade transitions deexcites the nucleus into an isomeric or
ground state. It has been observed experimentally that the IR for Ba
and Ce equals about 0.13 while in two heavier isotones it is even less
than half the size. To explain this effect, the structure of the excited states
in the energy region up to 6.5 MeV has been calculated within the Quasiparticle
Phonon Model. Many states are found connected to the ground and isomeric states
by , and transitions. The single-particle component of the wave
function is responsible for the large values of the transitions. The calculated
value of the isomeric ratio is in very good agreement with the experimental
data for all isotones. A slightly different value of maximum energy with which
the nuclei rest after neutron decay of the GDR is responsible for the reported
effect of the A-dependence of the IR.Comment: 16 pages, 4 Fig
Clinical Significance of Pathogenicity of Somatic Mutations in Oral Leukoplakia: a Prospective Observational Study
Background. The vast majority of malignant neoplasms of the oral mucosa refer to squamous cell carcinomas. The development of squamous cell carcinoma of the oral mucosa is often promoted by previous potentially malignant diseases, with oral leukoplakia dominating among them.Objective. To determine the clinical significance of the pathogenicity of somatic mutations in oral mucosal leukoplakia.Methods. The study material included 24 samples of abnormal epithelium of the oral mucosa from leukoplakia patients. QIAamp DNA FFPE Tissue Kit (Qiagen, Germany) was used for deoxyribonucleic acid (DNA) extraction from the samples. DNA sequencing was performed using IlluminaNextSeq 550 sequencer and TruSight™ Oncology 500 DNA Kit For Use with NextSeq (Illumina, USA). All DNA extractions from biological samples, preparation and sequencing of DNA libraries were performed step-by-step in strict accordance with the guidelines provided with the respective reagent kits. Bioinformatics analysis was carried out using specific software Illumina Base Space (Illumina, USA) and Galaxy Project (The Galaxy Community, a non-profit international project) according to current guidelines. The desired power of the study accounted for 90%. Two Proportions Z test was performed by means of The Sample Size Calculation of Statistica 12 (StatSoft, Inc.) with the set option “one-tailed hypothesis”, because it was initially assumed that pathogenic (oncogenic) genetic variants occur in the tissue of oral leukoplakia much more frequently than in the human reference genome used for sequence alignment.Results. The pathogenic somatic mutations in the TP53, KRAS, APC, NRAs and BRAF genes, identified in this study, alone or in combination, are highly likely (hazard ratio 3000-11000) to be associated with the development of oral mucosal leukoplakia and low-grade epithelial dysplasia. The multiplicity of pathogenic and likely pathogenic genetic variants associated with epithelial dysplasia, as well as the fact that a number of variants do not occur in all patients, suggests that the same histotype of oral mucosal dysplasia may develop under the influence of different mutations.Conclusion. The pathogenic and likely pathogenic variants of the TP53, KRAS, APC, NRAS and BRAF genes, identified in this study, alone or in combination, are highly likely (hazard ratio 3000–11000) to be associated with the development of leukoplakia and low-grade epithelial dysplasia
Germline mutations in patients with oral mucosal leukoplakia and squamous cell carcinoma: a prospective observational study
Background. The number of studies devoted to the molecular genetics of oral mucosal leukoplakia and squamous cell carcinoma is small, while the obtained results are usually preliminary in nature. We can assume the existence of region-specific pathogenic genetic variants involved in the development of oral mucosal leukoplakia and squamous cell carcinoma. With the knowledge of such variants, it would become possible to develop PCR (polymerase chain reaction) and NGS (next-generation sequencing) test systems for the detection of clinically significant germline mutations.Objectives — to identify pathogenic germline genetic variants in patients with oral mucosal leukoplakia accompanied by grade 1 epithelial dysplasia, as well as oral mucosal squamous cell carcinoma, using new-generation sequencing.Methods. Study design: prospective, observational, cross-sectional, without a control group. The sample included patients (48 persons) of either sex (18 years of age or older) with the following proven and morphologically confirmed diagnoses: oral mucosal leukoplakia accompanied by grade 1 squamous intraepithelial neoplasia of epithelium (24 people) and oral mucosal squamous cell carcinoma (24 people), who sought medical care at the Vitebsk Regional Clinical Dental Center and Vitebsk Regional Clinical Oncological Center in 2019–2020. The identified pathogenic and presumably pathogenic genetic variants involved in the development of these diseases were quantitatively assessed. The study was conducted at the Shareable Core Facilities GENOME of the Institute of Genetics and Cytology of the National Academy of Sciences of Belarus. In order to isolate deoxyribonucleic acid (DNA) from blood samples, a QIAamp DNA FFPE Tissue Kit (Qiagen, Germany) was used. The preparation of DNA libraries and sequencing were carried out by means of an Illumina NextSeq 550 sequencing system (Illumina, Inc., USA) using an Illumina Nextera DNA Exome kit (USA). Bioinformatic analysis was conducted using Illumina BaseSpace specialized software (USA) and Galaxy Project (Galaxy Community, an international non-profit project) in accordance with current guidelines. The obtained data were statistically processed employing specialized software packages Statistica 12 (StatSoft, Inc., USA) and MedCalc 18.9.1 (MedCalc Software, Ltd, Belgium).Results. Next-generation whole-exome sequencing of deoxyribonucleic acid samples isolated from the blood of patients with oral mucosal leukoplakia and squamous cell carcinoma has been conducted in the Republic of Belarus for the first time. The total number of unique germline genetic variants in the exome of both groups of patients was shown to be very high, yet most of them were not pathogenic. In the examined patients, the majority of germline mutations were found to be localized only in 19 exome genes: MAP2K3, DNAH5, HSPG2, OBSCN, SYNE1, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-A, HLA-B, PKD1L2, TTN, AHNAK2, PDE4DIP, MUC3A, MUC4, MUC12, MUC16, and MUC17. In both clinical groups, the greatest number of genetic variants (> 40% of the total number) was detected in MUC3A, MUC4, MUC12, and MUC16, responsible for the synthesis of the glycoprotein mucin family.Conclusion. Oral mucosal leukoplakia and squamous cell carcinoma can arise from the pathogenic variants of MUC3A, MUC4, MUC12, and MUC16
Small Horizons
All near horizon geometries of supersymmetric black holes in a N=2, D=5
higher-derivative supergravity theory are classified. Depending on the choice
of near-horizon data we find that either there are no regular horizons, or
horizons exist and the spatial cross-sections of the event horizons are
conformal to a squashed or round S^3, S^1 * S^2, or T^3. If the conformal
factor is constant then the solutions are maximally supersymmetric. If the
conformal factor is not constant, we find that it satisfies a non-linear vortex
equation, and the horizon may admit scalar hair.Comment: 21 pages, latex. Typos corrected and reference adde
Complete intersections: Moduli, Torelli, and good reduction
We study the arithmetic of complete intersections in projective space over
number fields. Our main results include arithmetic Torelli theorems and
versions of the Shafarevich conjecture, as proved for curves and abelian
varieties by Faltings. For example, we prove an analogue of the Shafarevich
conjecture for cubic and quartic threefolds and intersections of two quadrics.Comment: 37 pages. Typo's fixed. Expanded Section 2.
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