417 research outputs found
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Deliverable 6.1: Radio spectrum, traffic engineering and resource management
Predicting lung cancer recurrence from circulating tumour DNA. Commentary on 'Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution'
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Service Platform for Converged Interactive Broadband Broadcast and Cellular Wireless
A converged broadcast and telecommunication
service platform is presented that is able to create, deliver, and
manage interactive, multimedia content and services for consumption
on three different terminal types. The motivations of
service providers for designing converged interactive multimedia
services, which are crafted for their individual requirements, are
investigated. The overall design of the system is presented with
particular emphasis placed on the operational features of each
of the sub-systems, the flows of media and metadata through the
sub-systems and the formats and protocols required for inter-communication
between them. The key features of tools required for
creating converged interactive multimedia content for a range of
different end-user terminal types are examined. Finally possible
enhancements to this system are discussed. This study is of particular
interest to those organizations currently conducting trials
and commercial launches of DVB-H services because it provides
them with an insight of the various additional functions required
in the service provisioning platforms to provide fully interactive
services to a range of different mobile terminal types
Genome-wide analysis of Corsican population reveals a close affinity with Northern and Central Italy
Despite being the fourth largest island in the Mediterranean basin, the genetic variation of Corsica has not been explored as exhaustively as Sardinia, which is situated only 11 km South. However, it is likely that the populations of the two islands shared, at least in part, similar demographic histories. Moreover, the relative small size of the Corsica may have caused genetic isolation, which, in turn, might be relevant under medical and translational perspectives. Here we analysed genome wide data of 16 Corsicans, and integrated with newly (33 individuals) and previously generated samples from West Eurasia and North Africa. Allele frequency, haplotype-based, and ancient genome analyses suggest that although Sardinia and Corsica may have witnessed similar isolation and migration events, the latter is genetically closer to populations from continental Europe, such as Northern and Central Italians
Epigenetic regulation of RhoB loss of expression in lung cancer
<p>Abstract</p> <p>Background</p> <p>RhoB is down-regulated in most lung cancer cell lines and tumor tissues when compared with their normal counterparts. The mechanism of this loss of expression is not yet deciphered.</p> <p>Methods</p> <p>Since no mutation has been reported in the RhoB sequence, we investigated the epigenetic regulation of RhoB expression by analyzing the effect of HDAC inhibitors and methyltransferase inhibitors, by direct sequencing after bisulfite treatment and by methylation specific PCR.</p> <p>Results</p> <p>We first showed that histone deacetylase (HDAC) inhibitors induce a significant RhoB re-expression in lung cancer cell lines whereas only a slight effect was observed with methyl transferase inhibitors. As promoter methylation is the most common epigenetic process in lung cancer, we performed methylation specific PCR and sequence analysis after bisulfite treatment and demonstrated that RhoB was methylated neither in lung cancer cell lines nor in tumor tissues. We also showed that a variable number of tandem repeats sequences in the 5' region of the RhoB gene was involved in HDAC response.</p> <p>Conclusion</p> <p>We thus propose that RhoB regulation of expression occurs mainly by histone deacetylation rather than by promoter hypermethylation and that this process can be modulated by specific 5' sequences within the promoter.</p
Analyse des délais de prise en charge des cancers thoraciques : étude prospective
RĂ©sumĂ©IntroductionLe cancer broncho-pulmonaire est la premiĂšre cause de dĂ©cĂšs par cancer en France. Son diagnostic est le plus souvent tardif, alors que le dĂ©lai entre le dĂ©but des symptĂŽmes et la prise en charge est considĂ©rĂ© comme un facteur aggravant.MatĂ©riel et mĂ©thodesNotre Ă©tude prospective a recueilli les diffĂ©rentes dates de prise en charge de 139 patients consĂ©cutifs bĂ©nĂ©ficiant dâun traitement primaire pour un cancer thoracique dans notre hĂŽpital entre novembre 2008 et mai 2009. Lâobjectif de cette Ă©tude Ă©tait dâĂ©valuer diffĂ©rents dĂ©lais de prise en charge des patients porteurs dâun cancer thoracique quelle que soit sa prise en charge thĂ©rapeutique (mĂ©dicale ou chirurgicale) et de dĂ©terminer la cause de ces dĂ©lais.RĂ©sultatsLe dĂ©lai mĂ©dian entre la premiĂšre imagerie pathologique et le traitement est de 9,6 semaines. Les dĂ©lais Ă©taient significativement plus courts dans les stades tardifs et les carcinomes Ă petites cellules (p=0,001). Il existait une tendance Ă des dĂ©lais plus courts pour les femmes et des dĂ©lais plus longs pour les classes dâĂąge les plus Ă©levĂ©es.ConclusionLâĂ©valuation des dĂ©lais de prise en charge, en particulier pour les stades prĂ©coces, sâintĂšgre dans le contrĂŽle de la qualitĂ© de prise en charge de ces pathologies.SummaryIntroductionLung cancer is the main cause of cancer death in France. The diagnosis is often late and the delay between the onset of symptoms and management is considered an aggravating factor.Material and methodsOur prospective study collected the dates of the start of management of 139 consecutive patients receiving first line treatment for thoracic cancer in our hospital between November 2008 and May 2009. The aim of this study was to evaluate the delays in medical or surgical treatments in patients with thoracic cancer and to determine the cause of these delays.ResultsThe median delay between the first abnormal chest X-ray and treatment was 9.6 weeks. The delays were significantly shorter in the late stages and in small cell cancer (P=0.001). There was a tendency for shorter delays in women and for longer delays in older patients.ConclusionEvaluation of the delays in treatment, particularly in the early stages, is part of the quality control of management of these diseases
On p-saturable groups
AbstractA pro-p group G is a PF-group if it has central series of closed subgroups {Ni}iâN with trivial intersection satisfying N1=G and [Ni,G,âŠpâ1,G]â©œNi+1p. In this paper, we prove that a finitely generated pro-p group G is a p-saturable group, in the sense of Lazard, if and only if it is a torsion free PF-group. Using this characterization, we study certain families of subgroups of p-saturable groups. For example, we prove that any normal subgroup of a p-saturable group contained in the Frattini is again p-saturable
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