2 research outputs found
Metabolomics applied to maternal and perinatal health: a review of new frontiers with a translation potential
The prediction or early diagnosis of maternal complications is challenging mostly because the main conditions, such as preeclampsia, preterm birth, fetal growth restriction, and gestational diabetes mellitus, are complex syndromes with multiple underlying mechanisms related to their occurrence. Limited advances in maternal and perinatal health in recent decades with respect to preventing these disorders have led to new approaches, and "omics" sciences have emerged as a potential field to be explored. Metabolomics is the study of a set of metabolites in a given sample and can represent the metabolic functioning of a cell, tissue or organism. Metabolomics has some advantages over genomics, transcriptomics, and proteomics, as metabolites are the final result of the interactions of genes, RNAs and proteins. Considering the recent "boom" in metabolomic studies and their importance in the research agenda, we here review the topic, explaining the rationale and theory of the metabolomic approach in different areas of maternal and perinatal health research for clinical practitioners. We also demonstrate the main exploratory studies of these maternal complications, commenting on their promising findings. The potential translational application of metabolomic studies, especially for the identification of predictive biomarkers, is supported by the current findings, although they require external validation in larger datasets and with alternative methodologies.74CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTĂFICO E TECNOLĂGICO - CNPQCOORDENAĂĂO DE APERFEIĂOAMENTO DE PESSOAL DE NĂVEL SUPERIOR - CAPESSem informação88881.134095/2016-01; 8881.134512/2016-0
Metabolomics applied to maternal and perinatal health: a review of new frontiers with a translation potential
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S1807-59322019000100303.pdf: 766293 bytes, checksum: d3694a392a2120b7b8d5e91ffe93d3f0 (MD5)The prediction or early diagnosis of maternal complications is challenging mostly because the main conditions, such as preeclampsia, preterm birth, fetal growth restriction, and gestational diabetes mellitus, are complex syndromes with multiple underlying mechanisms related to their occurrence. Limited advances in maternal and perinatal health in recent decades with respect to preventing these disorders have led to new approaches, and âomicsâ sciences have emerged as a potential field to be explored. Metabolomics is the study of a set of metabolites in a given sample and can represent the metabolic functioning of a cell, tissue or organism. Metabolomics has some advantages over genomics, transcriptomics, and proteomics, as metabolites are the final result of the interactions of genes, RNAs and proteins. Considering the recent âboomâ in metabolomic studies and their importance in the research agenda, we here review the topic, explaining the rationale and theory of the metabolomic approach in different areas of maternal and perinatal health research for clinical practitioners. We also demonstrate the main exploratory studies of these maternal complications, commenting on their promising findings. The potential translational application of metabolomic studies, especially for the identification of predictive biomarkers, is supported by the current findings, although they require external validation in larger datasets and with alternative methodologies.Departamento de Ginecologia e Obstetricia Faculdade de Ciencias Medicas Universidade Estadual de CampinasDepartamento Materno Infantil Faculdade de Medicina Universidade Federal de PernambucoDepartamento de Ginecologia e Obstetricia Faculdade de Medicina de Botucatu Universidade Estadual de Sao Paulo (UNESP)Departamento de Ginecologia e Obstetricia Faculdade de Medicina Universidade Federal do Rio Grande do SulDepartamento de Ginecologia e Obstetricia Faculdade de Medicina Universidade Federal do CearaUniversity of LeicesterUniversity of CorkGravida: National Center for Growth & Development Liggins Institute University of AucklandSchool of Medical Sciences University of CampinasLNBioDepartment of Mother and Child Health School of Medicine Federal University of PernambucoSchool of Medicine of Botucatu UNESPHospital de ClĂnicas de Porto Alegre and School of Medicine Federal University of Rio Grande do SulSchool of Medicine Federal University of CearaDepartamento de Ginecologia e Obstetricia Faculdade de Medicina de Botucatu Universidade Estadual de Sao Paulo (UNESP)School of Medicine of Botucatu UNES