Adelante / Endavant

Séptimo desafío por la erradicación de la violencia contra las mujeres del Institut Universitari d’Estudis Feministes i de Gènere "Purificación Escribano" de la Universitat Jaume

The Educational Work and Life Project Professional college student. A necessary relationship in Higher Education

The new tendencies of the superior Cuban education, require of an educational renewing practice after contributing to the integral formation of the graduate future university, by achieving it harmonize the formation of sk ills and attitudes habits knowledges and the construction of a project of professional life sustained in values. In this sense the academic year constitutes the cell of the educational work to this level. Therefore at present it works try to get evaluate the necessary question between the educational labor and the project of professional life of the university student, with emphasis in the |protagónico| role of the social actors of the educational process

El trabajo Educativo y el Proyecto de Vida Profesional del estudiante universitario. Una relación necesaria en la Educación Superior

Las nuevas tendencias de la Educación Superior Cubana, requieren de una práctica educativa renovadora en pos de contribuir a la formación integral del futuro egresado universitario, logrando armonizar la formación de conocimientos hábitos habilidades y actitudes y la construcción de un proyecto de vida profesional sustentado en valores. En este sentido el año académico constituye la célula del trabajo educativo a este nivel, Por consiguiente en el presente trabajo pretendemos evaluar la necesaria articulación entre la labor educativa y el proyecto de vida profesional del estudiante universitario, con énfasis en el rol protagónico de los actores sociales del proceso educativo

Regioselective Mercury(I)/Palladium(II)-Catalyzed Single-Step Approach for the Synthesis of Imines and 2-Substituted Indoles

An efficient synthesis of ketimines was achieved through a regioselective Hg(I)-catalyzed hydroamination of terminal acetylenes in the presence of anilines. The Pd(II)-catalyzed cyclization of these imines into the 2-substituted indoles was satisfactorily carried out by a C-H activation. In a single-step approach, a variety of 2-substituted indoles were also generated via a Hg(I)/Pd(II)-catalyzed, one-pot, two-step process, starting from anilines and terminal acetylenes. The arylacetylenes proved to be more effective than the alkyl derivatives

Nanoparticles Formulation Improves the Antifibrogenic Effect of Quercetin on an Adenine-Induced Model of Chronic Kidney Disease

Renal fibrosis is the final stage of chronic kidney injury characterized by glomerulosclerosis and tubulointerstitial fibrosis with parenchymal destruction. Quercetin belongs to the most studied flavonoids with antioxidant, anti-inflammatory, antifibrogenic, and antitumor activity. It modifies the TGF-β/Smad signaling pathway, decreasing profibrogenic expression molecules and inducing the expression of antioxidant, anti-inflammatory, and antifibrogenic molecules. However, quercetin exhibits poor water solubility and low absorption and bioavailability. This limitation was solved by developing a nanoparticles formulation that improves the solubility and bioavailability of several bioactive compounds. Therefore, we aimed to investigate the in vivo antifibrogenic effect of a quercetin nanoparticles formulation. Male C57BL/6 mice were induced into chronic renal failure with 50 mg/kg of adenine for four weeks. The animals were randomly grouped and treated with 25, 50, or 100 mg/kg of quercetin, either macroparticles or nanoparticles formulation. We performed biochemical, histological, and molecular analyses to evaluate and compare the effect of macroparticles versus nanoparticles formulation on kidney damage. Here, we demonstrated that smaller doses of nanoparticles exhibited the same beneficial effect as larger doses of macroparticles on preventing kidney damage. This finding translates into less quercetin consumption reaching the desired therapeutic effect

HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1

The development of cervical cancer (CeCa) is associated with high-risk human papilloma virus (HR-HPV) infections, mainly HPV-16, which is present in more than 50% of cases. The presence of immunosuppressive factors in the early stages of the disease is also strongly linked to CeCa progression. In this context, it is unknown whether ectonucleotidases CD39 and CD73, which are involved in the production of adenosine (Ado) that suppresses the specific antitumor immune response, are present in precursor lesions of CeCa. In this pilot study, we analyzed the presence of CD39 and CD73 and their capacity to generate Ado in 25 cervical samples from patients with grade 1 cervical intraepithelial neoplasms (CIN-1) and 25 samples from normal donors (NDs) free of HPV infection. Cells obtained from cervical samples of CIN-1 patients positive for HPV-16 showed higher CD39 and CD73 contents compared to samples obtained from CIN-1 patients negative for HPV-16 and NDs. Interestingly, solubilized cervical mucus from these patients also showed higher contents of soluble CD39 and CD73, which were associated with a greater capacity to produce Ado from the hydrolysis of adenosine triphosphate (ATP) and adenosine monophosphate (AMP). In addition, serum samples of these patients showed higher levels of TGF-β than those of CIN-1 patients negative for HPV-16 and ND. These results suggest that persistent infection with HR-HPV, mostly HPV-16, in CIN-1 patients may promote the expression of CD39 and CD73 through the production of TGF-β in precursor lesions to generate an immunosuppressive microenvironment and allow its progression to CeCa

Detection of CD39 and a Highly Glycosylated Isoform of Soluble CD73 in the Plasma of Patients with Cervical Cancer: Correlation with Disease Progression

Persistent infection with high-risk human papillomavirus (HR-HPV) is the main factor in the development of cervical cancer (CC). The presence of immunosuppressive factors plays an important role in the development of this type of cancer. To determine whether CD39 and CD73, which participate in the production of immunosuppressive adenosine (Ado), are involved in the progression of CC, we compared the concentrations and hydrolytic activity of these ectonucleotidases in platelet-free plasma (PFP) samples between patients with low-grade squamous intraepithelial lesions (LSILs) (n=18), high-grade squamous intraepithelial lesions (HSILs) (n=12), and CC (n=19) and normal donors (NDs) (n=15). The concentrations of CD39 and CD73 in PFP increased with disease progression (r=0.5929, p<0.001). The PFP of patients with HSILs or CC showed the highest concentrations of CD39 (2.3 and 2.2 times that of the NDs, respectively) and CD73 (1.7 and 2.68 times that of the NDs, respectively), which were associated with a high capacity to generate Ado from the hydrolysis of adenosine diphosphate (ADP) and adenosine monophosphate (AMP). The addition of POM-1 and APCP, specific inhibitors of CD39 and CD73, respectively, inhibited the ADPase and AMPase activity of PFP by more than 90%. A high level of the 90 kD isoform of CD73 was detected in the PFP of patients with HSILs or CC. Digestion with endoglycosidase H and N-glycanase generated CD73 with weights of approximately 90 kD, 85 kD, 80 kD, and 70 kD. In addition, the levels of transforming grow factor-β (TGF-β) in the PFPs of patients with LSIL, HSIL and CC positively correlated with those of CD39 (r=0.4432, p<0.001) and CD73 (r=0.5786, p<0.001). These results suggest that persistent infection by HR-HPV and the concomitant production of TGF-β promote the expression of CD39 and CD73 to favor CC progression through Ado generation

Seminario de Investigación aplicada 2018-I

El programa de contaduría pública de la universidad piloto de Colombia seccional alto magdalena, precursor de la constante actualización de conocimientos contables, fiscales y financieros; entrega a la comunidad académica la siguiente recopilación de trabajos de grado, del periodo 2018-I, enfocados en la actualización de conceptos de las áreas anteriormente mencionadas y realizado por los estudiantes de último semestre en el marco del seminario de investigación aplicada. El mencionado seminario tuvo una duración de 160 horas asignadas de la siguiente manera: Gestión contable por parte del Contador público, especialista en gerencia de impuestos, revisoría fiscal y auditoria externa, con certificación internacional en normas internacionales de información financiera (NIIF) Argilio Acuña Gallego (40 horas), y el contador público con especialización en gerencia de proyectos y certificado internacionalmente en normas internacionales Jhon Wilson Castro Gaitán (40 horas), gestión fiscal dirigida por el contador público especialista en derecho tributario con diplomado en Normas internacionales (NIIF) Andrés Felipe Forero Gámez (40 Horas) y gestión financiera conducida por el contador público especialista en gerencia administrativa y financiera, gerencia de proyectos, certificado en normas internacionales (NIIF), con maestrías en auditoria y gestión, dirección estratégica, Carlos Armando Castaño Matallana (40 Horas). Teniendo en cuenta que el ámbito fiscal en Colombia es constantemente sometido a cambios, se presenta una guía práctica de reconocimiento, en la cual se aplican talleres teóricos – prácticos y se recopila distintos argumentos de los participantes, dando, así como resultado una monografía de conocimientos contables atreves de la investigación