What matters most to people around the world? Retrieving Better Life Index priorities on Twitter

Better Life Index (BLI), the measure of well-being proposed by the OECD, contains many metrics, which enable it to include a detailed overview of the social, economic, and environmental performances of different countries. However, this also increases the difficulty in evaluating the big picture. In order to overcome this, many composite BLI procedures have been proposed, but none of them takes into account societal priorities in the aggregation. One of the reasons for this is that at the moment there is no representative survey about the relative priorities of the BLI topics for each country. Using these priorities could help to design Composite Indices that better reflect the needs of the people. The largest collection of information about society is found in social media such as Twitter. This paper proposes a composite BLI based on the weighted average of the national performances in each dimension of the BLI, using the relative importance that the topics have on Twitter as weights. The idea is that the aggregate of millions of tweets may provide a representation of the priorities (the relative appreciations) among the eleven topics of the BLI, both at a general level and at a country-specific level. By combining topic performances and related Twitter trends, we produce new evidences about the relations between people's priorities and policy makers' activity in the BLI framework

A heparin-mimicking polymer conjugate stabilizes basic fibroblast growth factor.

Basic fibroblast growth factor (bFGF) is a protein that plays a crucial role in diverse cellular functions, from wound healing to bone regeneration. However, a major obstacle to the widespread application of bFGF is its inherent instability during storage and delivery. Here, we describe the stabilization of bFGF by covalent conjugation with a heparin-mimicking polymer, a copolymer consisting of styrene sulfonate units and methyl methacrylate units bearing poly(ethylene glycol) side chains. The bFGF conjugate of this polymer retained bioactivity after synthesis and was stable to a variety of environmentally and therapeutically relevant stressors--such as heat, mild and harsh acidic conditions, storage and proteolytic degradation--unlike native bFGF. Following the application of stress, the conjugate was also significantly more active than the control conjugate system in which the styrene sulfonate units were omitted from the polymer structure. This research has important implications for the clinical use of bFGF and for the stabilization of heparin-binding growth factors in general

Effects of precompetition state anxiety interventions on performance time and accuracy among amateur soccer players: Revisiting the matching hypothesis

In this study, we tested the matching ypothesis, which contends that administration of a cognitive or somatic anxiety intervention should be matched to a participant's dominant anxiety response. Sixty-one male soccer players (mean age 31.6 years, s=6.3) were assigned to one of four groups based on their responses to the Competitive State Anxiety Inventory-2, which was modified to include a directional scale. Interventions were randomly administered in a counterbalanced order 10 min before each performance trial on a soccer skill test. The dominantly cognitive anxious group (n=17), the dominantly somatic anxious group (n=17), and the non-anxious control intervention group (n=14) completed a baseline performance trial. The second and third trials were completed with random administration of brief cognitive and somatic interventions. The non-anxious control group (n=13) completed three trials with no intervention. A mixed-model, GroupTreatment multivariate analysis of variance indicated significant (P0.05), or performance time or accuracy (P>0.05). The present findings do not provide support for the matching hypothesis for state anxiety intensity and direction, or for performance

Online Abuse of UK MPs in 2015 and 2017: Perpetrators, Targets, and Topics

Concerns have reached the mainstream about how social media are affecting political outcomes. One trajectory for this is the exposure of politicians to online abuse. In this paper we use 1.4 million tweets from the months before the 2015 and 2017 UK general elections to explore the abuse directed at politicians. This collection allows us to look at abuse broken down by both party and gender and aimed at specific Members of Parliament. It also allows us to investigate the characteristics of those who send abuse and their topics of interest. Results show that in both absolute and proportional terms, abuse increased substantially in 2017 compared with 2015. Abusive replies are somewhat less directed at women and those not in the currently governing party. Those who send the abuse may be issue-focused, or they may repeatedly target an individual. In the latter category, accounts are more likely to be throwaway. Those sending abuse have a wide range of topical triggers, including borders and terrorism

Group selection models in prebiotic evolution

The evolution of enzyme production is studied analytically using ideas of the group selection theory for the evolution of altruistic behavior. In particular, we argue that the mathematical formulation of Wilson's structured deme model ({\it The Evolution of Populations and Communities}, Benjamin/Cumings, Menlo Park, 1980) is a mean-field approach in which the actual environment that a particular individual experiences is replaced by an {\it average} environment. That formalism is further developed so as to avoid the mean-field approximation and then applied to the problem of enzyme production in the prebiotic context, where the enzyme producer molecules play the altruists role while the molecules that benefit from the catalyst without paying its production cost play the non-altruists role. The effects of synergism (i.e., division of labor) as well as of mutations are also considered and the results of the equilibrium analysis are summarized in phase diagrams showing the regions of the space of parameters where the altruistic, non-altruistic and the coexistence regimes are stable. In general, those regions are delimitated by discontinuous transition lines which end at critical points.Comment: 22 pages, 10 figure

Finite-size scaling of the error threshold transition in finite population

The error threshold transition in a stochastic (i.e. finite population) version of the quasispecies model of molecular evolution is studied using finite-size scaling. For the single-sharp-peak replication landscape, the deterministic model exhibits a first-order transition at $Q=Q_c=1/a$, where $Q$ is the probability of exact replication of a molecule of length $L \to \infty$, and $a$ is the selective advantage of the master string. For sufficiently large population size, $N$, we show that in the critical region the characteristic time for the vanishing of the master strings from the population is described very well by the scaling assumption \tau = N^{1/2} f_a \left [ \left (Q - Q_c) N^{1/2} \right ] , where $f_a$ is an $a$-dependent scaling function.Comment: 8 pages, 3 ps figures. submitted to J. Phys.