Contribution de l'intimité à l'effet du soutien social dans la relation entre l'alexithymie et la dépression

Thèse numérisée par la Division de la gestion de documents et des archives de l'Université de Montréal

R-miss-tastic: a unified platform for missing values methods and workflows

Missing values are unavoidable when working with data. Their occurrence is exacerbated as more data from different sources become available. However, most statistical models and visualization methods require complete data, and improper handling of missing data results in information loss, or biased analyses. Since the seminal work of Rubin (1976), there has been a burgeoning literature on missing values with heterogeneous aims and motivations. This has resulted in the development of various methods, formalizations, and tools (including a large number of R packages and Python modules). However, for practitioners, it remains challenging to decide which method is most suited for their problem, partially because handling missing data is still not a topic systematically covered in statistics or data science curricula. To help address this challenge, we have launched a unified platform: "R-miss-tastic", which aims to provide an overview of standard missing values problems, methods, how to handle them in analyses, and relevant implementations of methodologies. In the same perspective, we have also developed several pipelines in R and Python to allow for a hands-on illustration of how to handle missing values in various statistical tasks such as estimation and prediction, while ensuring reproducibility of the analyses. This will hopefully also provide some guidance on deciding which method to choose for a specific problem and data. The objective of this work is not only to comprehensively organize materials, but also to create standardized analysis workflows, and to provide a common ground for discussions among the community. This platform is thus suited for beginners, students, more advanced analysts and researchers.Comment: 38 pages, 9 figure

Prospectus, January 27, 1982

ENROLLMENT INCREASES BY 7 PERCENT; News In Brief; Stugo president departs after vote on questionable issue; Two programs accredited; Before you vote…: Amendment is explained; StuGo needs student help; PC Counseling Center offers 6 new seminars; Join StuGo; PC Happenings: Workshop develops interest, Sign up for insurance, Ski Club enjoys trip, Balinese art displayed; Thunderbird pilots killed during practice; \u27Intercom\u27: pleasing results; All seals not created equal; Illinois to receive funding; Select proper microwave cookware; Overseas learning offers knowledge and fun; Cold weather doesn\u27t stop fun; Classifieds; \u27Great White North\u27: Canadian comic couple; Nothing too big for tiny star; \u27Images\u27: chance for publication; Center needs volunteers; Tickets reserved; New group leads the future of music; This week\u27s happenings: Clubs offer local talent; Book carries detective story into new science fiction area; Stray Cats lead revival of rockabilly music; Ice Capades skater sets example for Blacks; Program gives chance to travel in Spainhttps://spark.parkland.edu/prospectus_1982/1031/thumbnail.jp

Making Waves: Biocatalysis and Biosorption: Opportunities and Challenges Associated with a New Protein-Based Toolbox for Water and Wastewater Treatment

New water and wastewater treatment technologies are required to meet the demands created by emerging contaminants and resource recovery needs, yet technology development is a slow and uncertain process. Through evolution, nature has developed highly selective and fast-acting proteins that could help address these issues, but research and application have been limited, often due to assumptions about stability and economic feasibility. Here we highlight the potential advantages of cell-free, protein-based water and wastewater treatment processes (biocatalysis and biosorption), evaluate existing information about their economic feasibility, consider when a protein-based treatment process might be advantageous, and highlight key research needs

Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy

Mechanisms underlying the onset and progression of nephropathy in diabetic patients are not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease manifestation, therefore we hypothesized that proteases aberrantly expressed in diabetic nephropathy (DN) may be involved in the generation of DN-associated peptides in urine. We compared urinary peptide profiles of DN patients (macroalbuminuric, n = 121) to diabetic patients with no evidence of DN (normoalbuminuric, n = 118). 302 sequenced, differentially expressed peptides (adjusted p-value < 0.05) were analysed with the Proteasix tool predicting proteases potentially involved in their generation. Activity change was estimated based on the change in abundance of the investigated peptides. Predictions were correlated with transcriptomics (Nephroseq) and relevant protein expression data from the literature. This analysis yielded seventeen proteases, including multiple forms of MMPs, cathepsin D and K, kallikrein 4 and proprotein convertases. The activity of MMP-2 and MMP-9, predicted to be decreased in DN, was investigated using zymography in a DN mouse model confirming the predictions. Collectively, this proof-of-concept study links urine peptidomics to molecular changes at the tissue level, building hypotheses for further investigation in DN and providing a workflow with potential applications to other diseases

Assessing the discordance rate between local and central HER2 testing in women with locally determined HER2-negative breast cancer.

BackgroundThe importance of human epidermal growth factor receptor 2 (HER2) as a prognostic and predictive marker in invasive breast cancer is well established. Accurate assessment of HER2 status is essential to determine optimal treatment options.MethodsBreast cancer tumor tissue samples from the VIRGO observational cohort tissue substudy that were locally HER2-negative were retested centrally with both US Food and Drug Administration (FDA)-approved immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) assays, using FDA-approved assay cutoffs; results were compared.ResultsOf the 552 unique patient samples centrally retested with local HER2-negative results recorded, tumor samples from 22 (4.0%) patients were determined to be HER2-positive (95% confidence interval [CI] = 2.5%-5.7%). Of these, 18 had been tested locally by only one testing methodology; 15 of 18 were HER2-positive after the central retesting, based on the testing methodology not performed locally. Compared with the 530 patients with centrally confirmed HER2-negative tumors, the 22 patients with centrally determined HER2-positive tumors were younger (median age 56.5 versus 60.0 years) and more likely to have ER/PR-negative tumors (27.3% versus 22.3%). These patients also had shorter median progression-free survival (6.4 months [95% CI = 3.8-15.9 months] versus 9.1 months [95% CI = 8.3-10.3 months]) and overall survival (25.9 months [95% CI = 13.8-not estimable] versus 27.9 months [95% CI = 25.0-32.9 months]).ConclusionsThis study highlights the limitations of employing just one HER2 testing methodology in current clinical practice. It identifies a cohort of patients who did not receive potentially efficacious therapy because their tumor HER2-positivity was not determined by the test initially used. Because of inherent limitations in testing methodologies, it is inadvisable to rely on a single test to rule out potential benefit from HER2-targeted therapy

Manager Personality, Manager Service Quality Orientation, and Service Climate: Test of a Model

[Excerpt] Receiving poor customer service is an irritating experience. Often the first recourse for the customer is to ask to speak to the manager. Undoubtedly, customers make this request with the presumption that the manager plays a pivotal role in ensuring the delivery of service quality and can make things better. Situations where the manager fails to do so can be frustrating for both customers and subordinate employees. As important as managers are to service delivery, it is paradoxically true that due to the nature of service production, they have less control over service quality than their counterparts in manufacturing (Bowen & Schneider, 1988). Accordingly, managers in service organizations must create situations where the work environment is supportive of service quality (Schneider, White, & Paul, 1998). Schneider and his colleagues (e.g., Bowen & Schneider1988; Schneider, 1990; Schneider et al., 1998; Schneider & Gunnarson, 1990) have referred to this environment as a “climate for customer service.” Indeed, a number of studies (see Dean, 2004, for a review) have suggested that businesses that successfully create a climate for customer service tend to have customers who report higher service quality (Johnson, 1996). Moreover, service climate has a positive relationship with sales through its effects on customer satisfaction (Schneider, Ehrhart, Mayer, Saltz, & Niles-Jolly, 2005). The benefit of creating desired climates is not limited to service climates. This relationship is supported by research linking climate for safety to accidents (Barling, Loughlin, & Kelloway, 2002; Zohar, 2000; Zohar & Luria, 2004) and procedural justice climate to performance and absenteeism (Colquitt, Noe, & Jackson, 2002). Less documented is how such climates are created in the first place. One stream of research investigating the development of climates has focused on specific managerial behaviors, actions, and practices. For example, Zohar and Luria (2004) found that coherent or consistent managerial behaviors were significant predictors of safety climate. In this article, we seek to go back a step in the causal chain by exploring personality as an antecedent of managers’ service quality orientations. Following J. Hogan, Hogan, and Busch (1984), we define service quality orientation as a set of “attitudes and behaviors that affects the quality of the interaction between . . . the staff of any organization and its customers” (p. 167). Our proposal is that managers with certain personality traits are more likely to facilitate the development of a climate for service. Here, we seek to expand upon the work of numerous organizational scholars and to propose that managers with particular personality traits are more likely to exhibit a positive service quality orientation. In what follows, we develop a model explicating the links between personality, managerial service quality orientation, and a climate for customer service