Elementary Summer School: Culturally Responsive Practices and Academic Outcomes for English Learner Students in Grades 4–6

This mixed-method study explored the culturally responsive practices of a midsized, Southern California school district that used Expanded Learning Opportunities Program (ELOP) state funding to implement a voluntary summer program accessible to TK–6 grade students district-wide. Qualitative data gathered from semistructured interviews with the principal on special assignment (POSA), three upper-grade summer school teachers, and three school outreach liaisons (SOLs) highlighted the culturally responsive practices of the school district to address student and family needs, focusing specifically on English learners (ELs). Quantitative data from the school district examined included the summative test scores for EL students in Grades 4–6. Although EL summer school students did not score significantly higher than EL students who did not attend summer school, the findings demonstrated EL students increased their scaled scores in English language arts (ELA), math, and English Language Proficiency Assessments for California (ELPAC). A promising finding was the significant change in scores from before to after the summer school program for EL students. Although the study demonstrated funding alone did not address educational inequity as seen in test scores, the qualitative data highlighted powerful educational practices to help address the needs of students and families. Thus, the culturally responsive design features and practices of the summer school program are an initial start to supporting EL students and shifting the education system toward equity

Augmented generalized happy functions

An augmented happy function, $S_{[c,b]}$ maps a positive integer to the sum of the squares of its base-$b$ digits and a non-negative integer $c$. A positive integer $u$ is in a cycle of $S_{[c,b]}$ if, for some positive integer $k$, $S_{[c,b]}^k(u) = u$ and for positive integers $v$ and $w$, $v$ is $w$-attracted for $S_{[c,b]}$ if, for some non-negative integer $\ell$, $S_{[c,b]}^\ell(v) = w$. In this paper, we prove that for each $c\geq 0$ and $b \geq 2$, and for any $u$ in a cycle of $S_{[c,b]}$, (1) if $b$ is even, then there exist arbitrarily long sequences of consecutive $u$-attracted integers and (2) if $b$ is odd, then there exist arbitrarily long sequences of 2-consecutive $u$-attracted integers

Quorum Sensing Signal Production and Microbial Interactions in a Polymicrobial Disease of Corals and the Coral Surface Mucopolysaccharide Layer

Black band disease (BBD) of corals is a complex polymicrobial disease considered to be a threat to coral reef health, as it can lead to mortality of massive reef-building corals. The BBD community is dominated by gliding, filamentous cyanobacteria with a highly diverse population of heterotrophic bacteria. Microbial interactions such as quorum sensing (QS) and antimicrobial production may be involved in BBD disease pathogenesis. In this study, BBD (whole community) samples, as well as 199 bacterial isolates from BBD, the surface mucopolysaccharide layer (SML) of apparently healthy corals, and SML of apparently healthy areas of BBD-infected corals were screened for the production of acyl homoserine lactones (AHLs) and for autoinducer-2 (AI-2) activity using three bacterial reporter strains. AHLs were detected in all BBD (intact community) samples tested and in cultures of 5.5% of BBD bacterial isolates. Over half of a subset (153) of the isolates were positive for AI-2 activity. AHL-producing isolates were further analyzed using LC-MS/MS to determine AHL chemical structure and the concentration of (S)-4,5-dihydroxy-2,3-pentanedione (DPD), the biosynthetic precursor of AI-2. C6-HSL was the most common AHL variant detected, followed by 3OC4-HSL. In addition to QS assays, 342 growth challenges were conducted among a subset of the isolates, with 27% of isolates eliciting growth inhibition and 2% growth stimulation. 24% of BBD isolates elicited growth inhibition as compared to 26% and 32% of the bacteria from the two SML sources. With one exception, only isolates that exhibited AI-2 activity or produced DPD inhibited growth of test strains. These findings demonstrate for the first time that AHLs are present in an active coral disease. It is possible that AI-2 production among BBD and coral SML bacteria may structure the microbial communities of both a polymicrobial infection and the healthy coral microbiome

The epidemiology of dying within 48 hours of presentation to emergency departments: a retrospective cohort study of older people across Australia and New Zealand

BACKGROUND: Emergency department (ED) clinicians are more frequently providing care, including end-of-life care, to older people.OBJECTIVES: To estimate the need for ED end-of-life care for people aged ≥65 years, describe characteristics of those dying within 48 hours of ED presentation and compare those dying in ED with those dying elsewhere.METHODS: We conducted a retrospective cohort study analysing data from 177 hospitals in Australia and New Zealand. Data on older people presenting to ED from January to December 2018, and those who died within 48 hours of ED presentation, were analysed using simple descriptive statistics and univariate logistic regression.RESULTS: From participating hospitals in Australia or New Zealand, 10,921 deaths in older people occurred. The 48-hour mortality rate was 6.43 per 1,000 ED presentations (95% confidence interval: 6.31-6.56). Just over a quarter (n = 3,067, 28.1%) died in ED. About one-quarter of the cohort (n = 2,887, 26.4%) was triaged into less urgent triage categories. Factors with an increased risk of dying in ED included age 65-74 years, ambulance arrival, most urgent triage categories, principal diagnosis of circulatory system disorder, and not identifying as an Aboriginal or Torres Strait Islander person. Of the 7,677 older people admitted, half (n = 3,836, 50.0%) had an encounter for palliative care prior to, or during, this presentation.CONCLUSIONS: Our findings provide insight into the challenges of recognising the dying older patient and differentiating those appropriate for end-of-life care. We support recommendations for national advanced care planning registers and suggest a review of triage systems with an older person-focused lens.</p

Annual Report 2011 Operation and Utilisation of the High Flux Reactor

The High Flux Reactor (HFR) at Petten is managed by the Institute for Energy and Transport (IET) of the EC - DG JRC and operated by NRG who are also licence holder and responsible for commercial activities. The HFR operates at 45 MW and is of the tank-in-pool type, light water cooled and moderated. It is one of the most powerful multi-purpose materials testing reactors in the world and one of the world leaders in target irradiation for the production of medical radioisotopes.JRC.F-Institute for Energy and Transport (Petten

Comparison of Molecular Phenotypes of Ductal Carcinoma In Situ and Invasive Breast Cancer

Introduction: At least four major categories of invasive breast cancer that are associated with different clinical outcomes have been identified by gene expression profiling: luminal A, luminal B, human epidermal growth factor receptor 2 (HER2) and basal-like. However, the prevalence of these phenotypes among cases of ductal carcinoma in situ (DCIS) has not been previously evaluated in detail. The purpose of this study was to compare the prevalence of these distinct molecular subtypes among cases of DCIS and invasive breast cancer. Methods: We constructed tissue microarrays (TMAs) from breast cancers that developed in 2897 women enrolled in the Nurses' Health Study (1976 to 1996). TMA slides were immunostained for oestrogen receptor (ER), progesterone receptor (PR), HER2, cytokeratin 5/6 (CK5/6) and epidermal growth factor receptor (EGFR). Using these immunostain results, cases were grouped into molecularly defined subtypes. Results: The prevalence of the distinct molecular phenotypes differed significantly between DCIS (n = 272) and invasive breast cancers (n = 2249). The luminal A phenotype was significantly more frequent among invasive cancers (73.4%) than among DCIS lesions (62.5%) (p = 0.0002). In contrast, luminal B and HER2 molecular phenotypes were both more frequent among DCIS (13.2% and 13.6%, respectively) as compared with invasive tumours (5.2% and 5.7%, respectively) (p < 0.0001). The basal-like phenotype was more frequent among the invasive cancers (10.9%) than DCIS (7.7%), although this difference was not statistically significant (p = 0.15). High-grade DCIS and invasive tumours were more likely to be HER2 type and basal-like than low- or intermediate-grade lesions. Among invasive tumours, basal-like and HER2 type tumours were more likely to be more than 2 cm in size, high-grade and have nodal involvement compared with luminal A tumours. Conclusion: The major molecular phenotypes previously identified among invasive breast cancers were also identified among cases of DCIS. However, the prevalence of the luminal A, luminal B and HER2 phenotypes differed significantly between DCIS and invasive breast cancers

Exercise training induces depot-specific adaptations to white and brown adipose tissue

Exercise affects whole-body metabolism through adaptations to various tissues, including adipose tissue (AT). Recent studies investigated exercise-induced adaptations to AT, focusing on inguinal white adipose tissue (WAT), perigonadal WAT, and interscapular brown adipose tissue (iBAT). Although these AT depots play important roles in metabolism, they account for only ∼50% of the AT mass in a mouse. Here, we investigated the effects of 3 weeks of exercise training on all 14 AT depots. Exercise induced depot-specific effects in genes involved in mitochondrial activity, glucose metabolism, and fatty acid uptake and oxidation in each adipose tissue (AT) depot. These data demonstrate that exercise training results in unique responses in each AT depot; identifying the depot-specific adaptations to AT in response to exercise is essential to determine how AT contributes to the overall beneficial effect of exercise11425439This work was supported by National Institutes of Health grants R01-HL138738 and K01-DK105109 (to K.I.S.), R01-DK099511 (to L.J.G.), and 5P30 DK36836 (Joslin Diabetes Center DRC). The authors thank Nathan Makarewicz for editorial contribution

The Grizzly, November 21, 1995

The Quad Joins the Information Superhighway • Was Darwin Right?: Dr. Philip Johnson Discusses Evolution • Women are Moving Beyond The Double Bind • From Bed to Class in 3 Seconds Flat • Ursinus\u27 Tutoring Program • A New Music Revolution • The Great Pizza Caper • Welcome to the Miserable World of a Homosexual • God and the GOP • Dr. Nagy: Challenging the Claims • We\u27re Not Secure! • Final Exam Schedule • Alumna Spotlight: Janene Paist • Alien Lands at Ursinus: Observes Strange Life Forms • Flag Football Special • Lady Bears Contend For Mobil Championship • Season Opening Tourney Yields Split • Bears Place Four on Centennial All-Conference Teamhttps://digitalcommons.ursinus.edu/grizzlynews/1370/thumbnail.jp