Longitudinal and Quadrupolar Coupling Impedance of an Elliptical Vacuum Chamber With Finite Conductivity in Terms of Mathieu Functions

The resistive wall impedance of an elliptical vacuum chamber in the classical regime with infinite thickness is known analytically for ultra-relativistic beams by means of the Yokoya form factors. Starting from the longitudinal electric field of a point charge moving at arbitrary speed in an elliptical vacuum chamber, which we express in terms of Mathieu functions, in this paper we take into account the finite conductivity of the beam pipe walls and evaluate the longitudinal and quadrupolar impedance for any beam velocity. We also obtain that the quadrupolar impedance of a circular pipe is different from zero, approaching zero only for ultra-relativistic particles. Even if some of the results, in particular in the ultrarelativistic limit, are already known and expressed in terms of form factors, this approach is the first step towards the calculation of the general problem of a multi-layer vacuum chamber with different conductivities and of elliptic cross section

Wetting and spreading of commercially available aqueous surfactants on porous materials

The wetting properties of aqueous solutions of a commercially available surfactant at various concentrations on porous media are investigated using the KRUSS DSA100 shape analyzer and the ADVANCED software to process the data. Time evolution of both the contact angle and drop base diameter at each surfactant concentration after deposition were monitored. Three different porous substrates (sponges) were examined. The sponges used were a car sponge, dish sponge and audio sponge. The sponges were investigated both dry and at different degrees of saturation, that is, the amount of water absorbed into the sponge. It was found that pure distilled water droplets deposited on the dry porous media showed non-wetting. However, if droplets of surfactant solutions were deposited, then a change to a complete wetting case was found at all surfactant concentrations used. It has been observed that for all sponges, no matter the degree of saturation, they display a minimum contact angle after which the droplet is rapidly absorbed into the porous media

The Principle of Subsidiarity and the Multilevel Citizenship: The Future of Social Inclusion

The principle of subsidiarity was formally introduced in the European Union’s legislation framework in 1992 with the Treaty of Maastricht; although already in 1986, the European Single Act authorized Community action only if a specific objective could be better attained at the Community level. However, the subsidiarity principle inspiring the functionalist approach – according to which the best solution is always the most effective – can be found already in the Vedel Report (25 March 1972), aimed at examining the problem of the extension of the powers of the European Parliament. The principle of subsidiary is the reorganization of authority in the European Union (EU), an important policy-creating process in which authority and policy-making influences are shared across multiple levels of government

Influence of socio-demographic features and apolipoprotein E epsilon 4 expression on the prevalence of dementia and cognitive impairment in a population of 70-74-year olds: The InveCe.Ab study

Abstract The age-specific prevalence rates of dementia vary widely. Studies focusing on specific age groups are needed to provide reliable estimates for healthcare providers and policy makers. We estimated the prevalence of dementia, dementia subtypes and cognitive impairment in "InveCe.Ab" (ClinicalTrials.gov, NCT01345110 ), a single-step multidimensional population-based study of 70–74-year olds living in Abbiategrasso (Milan, Italy). We also looked for associations with socio-demographic factors and the presence of the apolipoprotein E-ɛ4 allele. The overall dementia prevalence was 3% (95%CI: 2.1–4.1%) [Alzheimer's disease (AD): 1.2% (95%CI 0.6–1.9%); vascular dementia (VD): 1.4% (95%CI: 0.8–2.2%)]. Being single was found to be a risk factor for vascular dementia; subjects born in southern Italy were shown to be at greater risk both of overall dementia and of vascular dementia. The prevalence of cognitive impairment, with or without subjective cognitive complaints (cognitive impairment, no dementia, CIND) was 7.8% (95%CI: 6.4–9.4%). As regards the CIND subgroups, the prevalence of subjects with subjective cognitive complaints (mild cognitive impairment, MCI) was 5.0% (95%CI 3.9–6.3%), while the prevalence of those without MCI (CIND-other) was 2.8% (95%CI: 1.9–3.8). The males had a higher risk of MCI and CIND-other; the older subjects were more likely to have MCI, and those born in north-eastern Italy to have CIND-other. The prevalence of AD was higher among the apolipoprotein E-ɛ4 carriers. Our data highlight the importance of dementia and cognitive impairment in the transitional period from adulthood to old age, and reveal the presence of different associations with socio-demographic and genetic factors

Life during COVID-19 lockdown in Italy: the influence of cognitive state on psychosocial, behavioral and lifestyle profiles of older adults.

Few studies have examined lockdown effects on the way of living and well-being of older adults stratified by cognitive state. Since cognitive deficits are common in this population, we investigated how cognition influenced their understanding of the pandemic, socio-behavioral responses and lifestyle adaptations during lockdown, and how these factors affected their mood or memory.Telephone-based survey involving 204 older adults ≥65 y/o (median: 82) with previous assessments of cognitive state: 164 normal-old (NOLD), 24 mild-neurocognitive disorder (mild-NCD), 18 mild-moderate dementia. A structured questionnaire was developed to assess psychological and socio-behavioral variables. Logistic regression was used to ascertain their effects on mood and memory.With increasing cognitive deficits, understanding of the pandemic and the ability to follow lockdown policies, adapt to lifestyle changes, and maintain remote interactions decreased. Participants with dementia were more depressed; NOLDs remained physically and mentally active but were more bored and anxious. Sleeping and health problems independently increased the likelihood of depression (OR: 2.29; CI: 1.06-4.93;NOLD and mild-NCD groups showed similar mood-behavioral profiles suggesting better tolerance of lockdown. Those with dementia were unable to adapt and suffered from depression and cognitive complaints. To counteract lockdown effects, physical and mental activities and digital literacy should be encouraged

Presentación de un estudio de intervención de estrategias de refuerzo pedagógico en una población de alumnos de Anatomía

Los nuevos paradigmas en la educación médica, se orientan a un modelo constructivista, en el que los estudiantes no solo participan sino que además puedan desarrollar un pensamiento crítico que les permita la autoformación ulterior. En ese sentido, es posible determinar algunas características personales de adherencia al estudio, en pos de aplicar estrategias personalizadas para un mejor rendimiento En esta comunicación presentamos nuestro estudio de estrategias de intervención a alumnos con adherencia inferior a la media del grupo.Facultad de Ciencias Médica

Presentación de un estudio de intervención de estrategias de refuerzo pedagógico en una población de alumnos de Anatomía

Los nuevos paradigmas en la educación médica, se orientan a un modelo constructivista, en el que los estudiantes no solo participan sino que además puedan desarrollar un pensamiento crítico que les permita la autoformación ulterior. En ese sentido, es posible determinar algunas características personales de adherencia al estudio, en pos de aplicar estrategias personalizadas para un mejor rendimiento En esta comunicación presentamos nuestro estudio de estrategias de intervención a alumnos con adherencia inferior a la media del grupo.Facultad de Ciencias Médica

Presentación de un estudio de intervención de estrategias de refuerzo pedagógico en una población de alumnos de Anatomía

Los nuevos paradigmas en la educación médica, se orientan a un modelo constructivista, en el que los estudiantes no solo participan sino que además puedan desarrollar un pensamiento crítico que les permita la autoformación ulterior. En ese sentido, es posible determinar algunas características personales de adherencia al estudio, en pos de aplicar estrategias personalizadas para un mejor rendimiento En esta comunicación presentamos nuestro estudio de estrategias de intervención a alumnos con adherencia inferior a la media del grupo.Facultad de Ciencias Médica

Evaluation of MLH1 variants of unclear significance

Inactivating mutations in the MLH1 gene cause the cancer predisposition Lynch syndrome, but for small coding genetic variants it is mostly unclear if they are inactivating or not. Nine such MLH1 variants have been identified in South American colorectal cancer (CRC) patients (p.Tyr97Asp, p.His112Gln, p.Pro141Ala, p.Arg265Pro, p.Asn338Ser, p.Ile501del, p.Arg575Lys, p.Lys618del, p.Leu676Pro), and evidence of pathogenicity or neutrality was not available for the majority of these variants. We therefore performed biochemical laboratory testing of the variant proteins and compared the results to protein in silico predictions on structure and conservation. Additionally, we collected all available clinical information of the families to come to a conclusion concerning their pathogenic potential and facilitate clinical diagnosis in the affected families. We provide evidence that four of the alterations are causative for Lynch syndrome, four are likely neutral and one shows compromised activity which can currently not be classified with respect to its pathogenic potential. The work demonstrates that biochemical testing, corroborated by congruent evolutionary and structural information, can serve to reliably classify uncertain variants when other data are insufficient.Barretos Cancer Hospital was partially funded by FINEP‐CT‐INFRA, Grant Number: 02/2010, Radium Hospital Foundation (Oslo, Norway), Helse Sør‐Øst (Norway); Deutsche Forschungsgemeinschaft, Grant Number: PL688/2‐1info:eu-repo/semantics/publishedVersio