CIWS-FW: a Customizable InstrumentWorkstation Software Framework for instrument-independent data handling

The CIWS-FW is aimed at providing a common and standard solution for the storage, processing and quick look at the data acquired from scientific instruments for astrophysics. The target system is the instrument workstation either in the context of the Electrical Ground Support Equipment for space-borne experiments, or in the context of the data acquisition system for instrumentation. The CIWS-FW core includes software developed by team members for previous experiments and provides new components and tools that improve the software reusability, configurability and extensibility attributes. The CIWS-FW mainly consists of two packages: the data processing system and the data access system. The former provides the software components and libraries to support the data acquisition, transformation, display and storage in near real time of either a data packet stream and/or a sequence of data files generated by the instrument. The latter is a meta-data and data management system, providing a reusable solution for the archiving and retrieval of the acquired data. A built-in operator GUI allows to control and configure the IW. In addition, the framework provides mechanisms for system error and logging handling. A web portal provides the access to the CIWS-FW documentation, software repository and bug tracking tools for CIWS-FW developers. We will describe the CIWS-FW architecture and summarize the project status.Comment: Accepted for pubblication on ADASS Conference Serie

Tumor Microenvironment Uses a Reversible Reprogramming of Mesenchymal Stromal Cells to Mediate Pro-tumorigenic Effects

The role of mesenchymal stromal cells (MSCs) in the tumor microenvironment is well described. Available data support that MSCs display anticancer activities, and that their reprogramming by cancer cells in the tumor microenvironment induces their switch toward pro-tumorigenic activities. Here we discuss the recent evidence of pro-tumorigenic effects of stromal cells, in particular (i) MSC support to cancer cells through the metabolic reprogramming necessary to maintain their malignant behavior and stemness, and (ii) MSC role in cancer cell immunosenescence and in the establishment and maintenance of immunosuppression in the tumor microenvironment. We also discuss the mechanisms of tumor microenvironment mediated reprogramming of MSCs, including the effects of hypoxia, tumor stiffness, cancer-promoting cells, and tumor extracellular matrix. Finally, we summarize the emerging strategies for reprogramming tumor MSCs to reactivate anticancer functions of these stromal cells

Emerging data supporting stromal cell therapeutic potential in cancer: reprogramming stromal cells of the tumor microenvironment for anti-cancer effects

After more than a decade of controversy on the role of stromal cells in the tumor microenvironment, the emerging data shed light on pro-tumorigenic and potential anti-cancer factors, as well as on the roots of the discrepancies. We discuss the pro-tumorigenic effects of stromal cells, considering the effects of tumor drivers like hypoxia and tumor stiffness on these cells, as well as stromal cell-mediated adiposity and immunosuppression in the tumor microenvironment, and cancer initiating cells' cellular senescence and adaptive metabolism. We summarize the emerging data supporting stromal cell therapeutic potential in cancer, discuss the possibility to reprogram stromal cells of the tumor microenvironment for anti-cancer effects, and explore some causes of discrepancies on the roles of stromal cells in cancer in the available literature

Duality and Braiding in Twisted Quantum Field Theory

We re-examine various issues surrounding the definition of twisted quantum field theories on flat noncommutative spaces. We propose an interpretation based on nonlocal commutative field redefinitions which clarifies previously observed properties such as the formal equivalence of Green's functions in the noncommutative and commutative theories, causality, and the absence of UV/IR mixing. We use these fields to define the functional integral formulation of twisted quantum field theory. We exploit techniques from braided tensor algebra to argue that the twisted Fock space states of these free fields obey conventional statistics. We support our claims with a detailed analysis of the modifications induced in the presence of background magnetic fields, which induces additional twists by magnetic translation operators and alters the effective noncommutative geometry seen by the twisted quantum fields. When two such field theories are dual to one another, we demonstrate that only our braided physical states are covariant under the duality.Comment: 35 pages; v2: Typos correcte

Multi-Investigator Letter on Reproducibility of Neonatal Heart Regeneration following Apical Resection

We appreciate the interest that Andersen et al. (2014) have shown in our work on neonatal cardiac regeneration. Their recent paper relates directly to resection methodology first presented by Porrello et al. (2011) and describes a failure to reproduce the observations made in that study regarding regeneration after resection. We are puzzled by the results and conclusion because in the hands of the seven different groups who authored this letter, this methodology has proved robust and reproducible and has been used in several ongoing studies across our different laboratories that are in various stages of completion (Heallen et al., [2013], as well as studies by the Lee, Takeuchi, and Nei groups that are currently under review). Importantly, several independent groups had similar observations using various types of neonatal injury (Strungs et al., 2013; Haubner et al., 2012; Naqvi et al., 2014; Jesty et al., 2012), where an increase in cardiomyocytes was also observed. Having carefully examined the study published by Andersen et al. (2014), it is our overall impression that methodological differences are likely to account for the difference in published results. Although it is difficult to draw clear conclusions about such differences without a detailed analysis of primary data, our impression is that variations in surgical technique, amount of resected myocardium, methods of quantification of resected and regenerated myocardium, and methods of assessment of myocyte proliferation form the basis of the differences seen. In particular, we used ventricular weight and surface area immediately after resection and 21 days later to assess the degree of injury and regeneration, while the Andersen group used HW/BW immediately after resection and ventricular weight 21 days later. Notably, in Figure 1E of the Andersen et al., 2014, paper, the amount of resected myocardium by ventricular weight 2 days after resection was in excess of 40%. We have not examined the effect of resection of such a large segment of the myocardium, but it is plausible that it not compatible with regeneration. We stand by the reproducibility of the initial report and we would be happy to assist Andersen et al. (2014) with various technical aspects of the neonatal apical resection method

International Coercion, Emulation and Policy Diffusion: Market-Oriented Infrastructure Reforms, 1977-1999

Why do some countries adopt market-oriented reforms such as deregulation, privatization and liberalization of competition in their infrastructure industries while others do not? Why did the pace of adoption accelerate in the 1990s? Building on neo-institutional theory in sociology, we argue that the domestic adoption of market-oriented reforms is strongly influenced by international pressures of coercion and emulation. We find robust support for these arguments with an event-history analysis of the determinants of reform in the telecommunications and electricity sectors of as many as 205 countries and territories between 1977 and 1999. Our results also suggest that the coercive effect of multilateral lending from the IMF, the World Bank or Regional Development Banks is increasing over time, a finding that is consistent with anecdotal evidence that multilateral organizations have broadened the scope of the “conditionality” terms specifying market-oriented reforms imposed on borrowing countries. We discuss the possibility that, by pressuring countries into policy reform, cross-national coercion and emulation may not produce ideal outcomes.http://deepblue.lib.umich.edu/bitstream/2027.42/40099/3/wp713.pd

85Peg A: which age for a low metallicity solar like star?

We explore the possible evolutionary status of the primary component of the binary 85 Pegasi, listed as a target for asteroseismic observations by the MOST satellite. In spite of the assessed `subdwarf' status, and of the accurate distance determination from the Hipparcos data, the uncertainties in the metallicity and age, coupled with the uncertainty in the theoretical models, lead to a range of predictions on the oscillation frequency spectrum. Nevertheless, the determination of the ratio between the small separation in frequency modes, and the large separation as suggested by Roxburgh (2004), provides a very good measure of the star age, quite independent of the metallicity in the assumed uncertainty range. In this range, the constraint on the dynamical mass and the further constraint provided by the assumption that the maximum age is 14 Gyr limit the mass of 85PegA to the range from 0.75 to 0.82Msun. This difference of a few hundreths of solar masses leads to well detectable differences both in the evolutionary stage (age) and in the asteroseismic properties. We show that the age determination which will be possible through the asteroseismic measurements for this star is independent either from the convection model adopted or from the microscopic metal diffusion. The latter conclusion is strengthened by the fact that, although metal diffusion is still described in an approximate way, recent observations suggest that the real stars suffer a smaller metal sedimentation with respect to the models.Comment: accepted for publication in the MNRA