Multiparametric Analysis of Factors Associated With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps.

Introduction: Previous studies have reported a diverse range of threshold values for blood eosinophilia. In addition, a single predictive biomarker for eosinophilic chronic rhinosinusitis (CRS) with nasal polyps (ECRSwNP) has not yet been identified. Objectives: The aim of this study is to compare the clinical characteristics of ECRSwNP and non-ECRSwNP to evaluate the preoperative risk of tissue eosinophilia of chronic rhinosinusitis with nasal polyps (CRSwNP) through a multiparametric statistical analysis. Methods: One hundred ten patients with evidence of chronic polypoid rhinosinusitis were included in this study and clinical records were retrospectively reviewed. Eosinophilic CRSwNP was diagnosed based on the presence of at least 10 eosinophils per high-power field. The demographic and clinical features of ECRSwNP and non-ECRSwNP are described. The values of blood eosinophilia as predictors of tissue eosinophilia have been identified using receiver operating characteristic curves. As the predictive value of the identified cutoff through regression analysis was low, we evaluated whether other risk factors could be statistically associated with ECRSwNP, and from this, a new predictive model was proposed for the identification of eosinophilic nasal polyps before surgery. Results: We found that the best method for predicting ECRSwNP is based on a model having asthma, blood eosinophil percentage, posterior ethmoid value in Lund-Mackay score, and modified Lund-Kennedy score as explanatory variables. Conclusions: This study provides new data for a better understanding of the polypoid CRS endotypes, and the proposed model allows the endotype to be identified preoperatively

towards optimum energy utilization by using the inverters for industrial production

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toward a real time reconfiguration of self adaptive smart assembly systems

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real time assistance to manual assembly through depth camera and visual feedback

Abstract The current fourth industrial revolution significantly impacts on production processes. The personalized production paradigm enables customers to order unique products. The operators assemble an enormous component variety adapting their process from product to product with limited learning opportunities. Digital technologies are increasingly adopted in production processes to improve performance and quality. Considering this framework, this research proposes a hardware/software architecture to assist in real-time operators involved in manual assembly processes. A depth camera captures human motions in relation with the workstation environment whereas a visual feedback guides the operator through consecutive assembly tasks. An industrial case study validates the architecture

3D MODELS FOR ALL: LOW-COST ACQUISITION THROUGH MOBILE DEVICES IN COMPARISON WITH IMAGE BASED TECHNIQUES. POTENTIALITIES AND WEAKNESSES IN CULTURAL HERITAGE DOMAIN

Nowadays, 3D digital imaging proposes effective solutions for preserving the expression of human creativity across the centuries, as well as is a great tool to guarantee global dissemination of knowledge and wide access to these invaluable resources of the past. Nevertheless, in several cases, a massive digitalisation of cultural heritage items (from the archaeological site up to the monument and museum collections) could be unworkable due to the still high costs in terms of equipment and human resources: 3D acquisition technologies and the need of skilled team within cultural institutions. Therefore, it is necessary to explore new possibilities offered by growing technologies: the lower costs of these technologies as well as their attractive visual quality constitute a challenge for researchers. Besides these possibilities, it is also important to consider how information is spread through graphic representation of knowledge. The focus of this study is to explore the potentialities and weaknesses of a newly released low cost device in the cultural heritage domain, trying to understand its effective usability in museum collections. The aim of the research is to test their usability, critically analysing the final outcomes of this entry level technology in relation to the other better assessed low cost technologies for 3D scanning, such as Structure from Motion (SfM) techniques (also produced by the same device) combined with dataset generated by a professional digital camera. The final outcomes were compared in terms of quality definition, time processing and file size. The specimens of the collections of the Civic Museum Castello Ursino in Catania have been chosen as the site of experimentation

The early bee catches the flower - circadian rhythmicity influences learning performance in honey bees, Apis mellifera

Circadian rhythmicity plays an important role for many aspects of honey bees’ lives. However, the question whether it also affects learning and memory remained unanswered. To address this question, we studied the effect of circadian timing on olfactory learning and memory in honey bees Apis mellifera using the olfactory conditioning of the proboscis extension reflex paradigm. Bees were differentially conditioned to odours and tested for their odour learning at four different “Zeitgeber” time points. We show that learning behaviour is influenced by circadian timing. Honey bees perform best in the morning compared to the other times of day. Additionally, we found influences of the light condition bees were trained at on the olfactory learning. This circadian-mediated learning is independent from feeding times bees were entrained to, indicating an inherited and not acquired mechanism. We hypothesise that a co-evolutionary mechanism between the honey bee as a pollinator and plants might be the driving force for the evolution of the time-dependent learning abilities of bees

Push/Pull Parts Production Policy Optimization in the ATO Environment

Within the Assembly to Order (ATO) production strategy, the common approach is to produce the parts to assemble with a Push-Make to Stock policy.In recent decades, the effects of the modern Just in Time (JIT) moved to a Pull-Make to Order policy. Assembled parts characterized by wide variety and huge storage space utilization are critical, and a proper Push/Pull production policy definition is required. An appropriate balance of storage space utilization and setup times leads to the optimization of the production policy. The aim of this paper is to define a bi-objective mathematical optimization model to assign the most suitable production policy to the parts within the production mix in an ATO industrial context. A numerical simulation and an operative case study showcases the model application, proving the industrial relevance of this research

Design, engineering and testing of an innovative adaptive automation assembly system

Purpose \u2013 Industry 4.0 emerged as the Fourth Industrial Revolution aiming at achieving higher levels of operational efficiency, productivity and automation. In this context, manual assembly systems are still characterized by high flexibility and low productivity, if compared to fully automated systems. Therefore, the purpose of this paper is to propose the design, engineering and testing of a prototypal adaptive automation assembly system, including greater levels of automation to complement the skills and capabilities of human workers. Design/methodology/approach \u2013 A lab experimental field-test is presented comparing the assembly process of a full-scale industrial chiller with traditional and adaptive assembly system. Findings \u2013 The analysis shows relevant benefits coming from the adoption of the adaptive automation assembly system. In particular, the main findings highlight improvements in the assembly cycle time and productivity, as well as reduction of the operator\u2019s body movements. Practical implications \u2013 The prototype is applied in an Italian mid-size industrial company, confirming its impact in terms of upgrades of the assembly system flexibility and productivity. Thus, the research study proposed in this paper provides valuable knowledge to support companies and industrial practitioners in the shift from traditional to advanced assembly systems matching current industrial and market features. Originality/value \u2013 This paper expands the lacking research on adaptive automation assembly systems design proposing an innovative prototype able to real-time reconfigure its structure according to the product to work, e.g. work cycle, and the operator features