12 research outputs found
A randomized controlled trial to evaluate the effect of a new skincare regimen on skin barrier function in those with podoconiosis in Ethiopia.
BACKGROUND: Podoconiosis affects an estimated 3 million people in Ethiopia with a further 19 million at risk. Volcanic soil and pathogens enter skin breaches in the feet causing inflammation, lymphoedema and hyperkeratosis. There is no robust evidence on optimal podoconiosis skincare regimens to improve skin barrier function (SBF). OBJECTIVES: To evaluate the effectiveness of a new, low-cost, evidence-based intervention to improve SBF in the lower limbs of those with podoconiosis. METHODS: A randomized controlled trial (NCT02839772) was conducted over 3 months in two podoconiosis clinics (n = 193). The intervention comprised 2% (v/v) glycerine added to a reduced volume of soaking water. The control group received the current skincare regimen. Primary outcome measures were transepidermal water loss (TEWL) and stratum corneum hydration (SCH) at four specific sites on the lower limbs. RESULTS: Improvement in SBF was observed in both groups across all measurement sites and time points, although this was significantly greater in the experimental group. TEWL reduced in both groups at all sites. For example, on top of the foot the estimated group difference in TEWL at visit 4 was 1路751 [standard error (SE) = 0路0390] in favour of the experimental group [t = 3路15, degrees of freedom (df) = 189路58, P = 0路002, 95% confidence interval (CI) 0路066-2路85], indicating a greater reduction in TEWL in the experimental group. Similarly, at the same site the estimated group difference in SCH at visit 4 was -2路041 (SE = 0路572) in favour of the experimental group (t = -3路56, df = 186路74, P < 0路001, 95% CI -3路16 to -0路91), indicating a greater increase in SCH in the experimental group. There were also significantly greater reductions in odour, number of wounds and largest foot circumference in the experimental vs. the control group. CONCLUSIONS: The addition of 2% (v/v) glycerol to a reduced volume (83% reduction) of soaking water significantly improved SBF
Bacterial metabolism of short-chain alkyl sulphate esters
SIGLEAvailable from British Library Document Supply Centre- DSC:DX97746 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Topical niacinamide does not stimulate hair growth based on the existing body of evidence
Niacinamide mitigates SASP鈥恟elated inflammation induced by environmental stressors in human epidermal keratinocytes and skin
Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin1
The myth of hidden ovulation: Shape and texture changes in the face during the menstrual cycle
In recent years, evidence has been gathered indicating increased attractiveness of female faces at the point of ovulation. In this paper, we asked what changes in facial appearance occur during menstrual cycle that lead to this shift in attractiveness. We analysed facial photographs of 20 young women with a normal cycle. We found evidence for textural changes, as well as shape changes that might account for the ovulatory peak in attractiveness. Generally, facial shape at ovulation is perceived as more attractive-and ovulating women are perceived as more attractive the closer their face shape is to the "ovulation shape". These findings support the hypothesis that attractive signals might be rooted in signals of fertility