546 research outputs found
State-space solutions to the dynamic magnetoencephalography inverse problem using high performance computing
Determining the magnitude and location of neural sources within the brain
that are responsible for generating magnetoencephalography (MEG) signals
measured on the surface of the head is a challenging problem in functional
neuroimaging. The number of potential sources within the brain exceeds by an
order of magnitude the number of recording sites. As a consequence, the
estimates for the magnitude and location of the neural sources will be
ill-conditioned because of the underdetermined nature of the problem. One
well-known technique designed to address this imbalance is the minimum norm
estimator (MNE). This approach imposes an regularization constraint that
serves to stabilize and condition the source parameter estimates. However,
these classes of regularizer are static in time and do not consider the
temporal constraints inherent to the biophysics of the MEG experiment. In this
paper we propose a dynamic state-space model that accounts for both spatial and
temporal correlations within and across candidate intracortical sources. In our
model, the observation model is derived from the steady-state solution to
Maxwell's equations while the latent model representing neural dynamics is
given by a random walk process.Comment: Published in at http://dx.doi.org/10.1214/11-AOAS483 the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org
A fully pipelined memoryless 17.8 Gbps AES-128 encryptor
A fully pipelined implementation of the Advanced Encryption Stan-dard encryption algorithm with 128-bit input and key length (AES-128) was implemented on Xilinx â Virtex-E and Virtex-II devices. The design is called SIG-AES-E and it implements the S-boxes combinatorially and thus requires no internal memory. It is con-cluded, that SIG-AES-E is faster than other published FPGA-based implementations of the AES-128 encryption algorithm. Categories and Subject Descriptor
Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25
AbstractProtein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain elusive. We combined pharmacological manipulations of kinase and phosphatase activities with mutational studies on the exocytotic machinery driving fusion of catecholamine-containing vesicles from chromaffin cells. We found that constitutive PKA activity was necessary to maintain a large number of vesicles in the release-ready, so-called primed, state, whereas calcineurin (protein phosphatase 2B) activity antagonized this effect. Overexpression of the SNARE protein SNAP-25a mutated in a PKA phosphorylation site (Thr-138) eliminated the effect of PKA inhibitors on the vesicle priming process. Another, unidentified, PKA target regulated the relative size of two different primed vesicle pools that are distinguished by their release kinetics. Overexpression of the SNAP-25b isoform increased the size of both primed vesicle pools by a factor of two, and mutations in the conserved Thr-138 site had similar effects as in the a isoform
Holographic Conformal Window - A Bottom Up Approach
We propose a five-dimensional framework for modeling the background geometry
associated to ordinary Yang-Mills (YM) as well as to nonsupersymmetric gauge
theories possessing an infrared fixed point with fermions in various
representations of the underlying gauge group. The model is based on the
improved holographic approach, on the string theory side, and on the
conjectured all-orders beta function for the gauge theory one. We first analyze
the YM gauge theory. We then investigate the effects of adding flavors and show
that, in the holographic description of the conformal window, the geometry
becomes AdS when approaching the ultraviolet and the infrared regimes. As the
number of flavors increases within the conformal window we observe that the
geometry becomes more and more of AdS type over the entire energy range.Comment: 20 Pages, 3 Figures. v2: references adde
Publisher Correction: Deep learning enables fast and dense single-molecule localization with high accuracy
In the version of this Article initially published, Jacob H. Macke and Jonas Ries were not listed as corresponding authors. Their contact information and designation as corresponding authors are now included. The error has been corrected in the online version of the Article
Electromagnetic wormholes via handlebody constructions
Cloaking devices are prescriptions of electrostatic, optical or
electromagnetic parameter fields (conductivity , index of refraction
, or electric permittivity and magnetic permeability
) which are piecewise smooth on and singular on a
hypersurface , and such that objects in the region enclosed by
are not detectable to external observation by waves. Here, we give related
constructions of invisible tunnels, which allow electromagnetic waves to pass
between possibly distant points, but with only the ends of the tunnels visible
to electromagnetic imaging. Effectively, these change the topology of space
with respect to solutions of Maxwell's equations, corresponding to attaching a
handlebody to . The resulting devices thus function as
electromagnetic wormholes.Comment: 25 pages, 6 figures (some color
Tuning metal/superconductor to insulator/superconductor coupling via control of proximity enhancement between NbSe monolayers
The interplay between charge transfer and electronic disorder in
transition-metal dichalcogenide multilayers gives rise to superconductive
coupling driven by proximity enhancement, tunneling and superconducting
fluctuations, of a yet unwieldy variety. Artificial spacer layers introduced
with atomic precision change the density of states by charge transfer. Here, we
tune the superconductive coupling between NbSe monolayers from
proximity-enhanced to tunneling-dominated. We correlate normal and
superconducting properties in [(SnSe)][NbSe]
tailored multilayers with varying SnSe layer thickness. From high-field
magnetotransport the critical fields yield Ginzburg-Landau coherence lengths
with an increase of 140 % cross-plane , trending towards two-dimensional
superconductivity for m > 9. We show cross-over between three regimes: metallic
with proximity-enhanced coupling, disordered-metallic with intermediate
coupling and insulating with Josephson tunneling. Our results demonstrate that
stacking metal mono- and dichalcogenides allows to convert a
metal/superconductor into an insulator/superconductor system, prospecting the
control of two-dimensional superconductivity in embedded layers.Comment: Revised version submitted to Journal of Physics: Condensed Matte
Fluctuations of a holographic quantum Hall fluid
We analyze the neutral spectrum of the holographic quantum Hall fluid
described by the D2-D8' model. As expected for a quantum Hall state, we find
the system to be stable and gapped and that, at least over much of the
parameter space, the lowest excitation mode is a magneto-roton. In addition, we
find magneto-rotons in higher modes as well. We show that these magneto-rotons
are direct consequences of level crossings between vector and scalar modes.Comment: 20 pages, 8 figures; v.2 figures improved, 2 figures added, and text
clarified particularly in Sec. 5, to appear in JHE
Full-wave invisibility of active devices at all frequencies
There has recently been considerable interest in the possibility, both
theoretical and practical, of invisibility (or "cloaking") from observation by
electromagnetic (EM) waves. Here, we prove invisibility, with respect to
solutions of the Helmholtz and Maxwell's equations, for several constructions
of cloaking devices. Previous results have either been on the level of ray
tracing [Le,PSS] or at zero frequency [GLU2,GLU3], but recent numerical [CPSSP]
and experimental [SMJCPSS] work has provided evidence for invisibility at
frequency . We give two basic constructions for cloaking a region
contained in a domain from measurements of Cauchy data of waves at \p
\Omega; we pay particular attention to cloaking not just a passive object, but
an active device within , interpreted as a collection of sources and sinks
or an internal current.Comment: Final revision; to appear in Commun. in Math. Physic
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