Dipole operator constraints on composite Higgs models

Flavour- and CP-violating electromagnetic or chromomagnetic dipole operators in the quark sector are generated in a large class of new physics models and are strongly constrained by measurements of the neutron electric dipole moment and observables sensitive to flavour-changing neutral currents, such as the $B\to X_s\gamma$ branching ratio and $\epsilon'/\epsilon$. After a model-independent discussion of the relevant constraints, we analyze these effects in models with partial compositeness, where the quarks get their masses by mixing with vector-like composite fermions. These scenarios can be seen as the low-energy limit of composite Higgs or warped extra dimensional models. We study different choices for the electroweak representations of the composite fermions motivated by electroweak precision tests as well as different flavour structures, including flavour anarchy and $U(3)^3$ or $U(2)^3$ flavour symmetries in the strong sector. In models with "wrong-chirality" Yukawa couplings, we find a strong bound from the neutron electric dipole moment, irrespective of the flavour structure. In the case of flavour anarchy, we also find strong bounds from flavour-violating dipoles, while these constraints are mild in the flavour-symmetric models.Comment: 30 pages, 2 figures, 11 tables. v3: Misprints in table 8 corrected. Numerics and conclusions unchange

Fiscal consolidation in the euro area: long-run benefits and short-run costs.

In this paper, we examine the macroeconomic effects of alternative fiscal consolidation policies in the New Area-Wide Model (NAWM), a two-country open-economy model of the euro area developed at the European Central Bank (cf. Coenen et al., 2007). We model fiscal consolidation as a permanent reduction in the targeted government debt-to-output ratio and analyse both expenditure and revenue-based policies that are implemented by means of simple fiscal feedback rules. We find that fiscal consolidation has positive long-run effects on key macroeconomic aggregates such as output and consumption, notably when the resulting improvement in the budgetary position is used to lower distortionary taxes. At the same time, fiscal consolidation gives rise to noticeable short-run adjustment costs in contrast to what the literature on expansionary fiscal consolidations suggests. Moreover, depending on the fiscal instrument used, fiscal consolidation may have pronounced distributional effects. JEL Classification: E32, E62euro area, fiscal consolidation, Fiscal Policy, Keywords: DSGE modelling, limited asset-market participation

The recent landscape history of Limpach valley, Switzerland: considering three empirical hypotheses on driving forces of landscape change

Understanding global landscape dynamics is a core challenge for the newly emerged field of land change science. Such an understanding requires insights into general pattern of landscape changes and the related driving forces. Many case studies of landscape change exist, but only few attempts have been made, to synthesize the results and to search for general pattern. We suggest that applying hypotheses on driving forces of landscape change derived from one case study in another region as a promising way to advance towards a more integrative view on landscape dynamics. Based on the conclusions drawn in a case study conducted in Godmanchester (Quebec, Canada; Domon and Bouchard 2007), we formulated three hypotheses and discussed them in a case study on landscape change in the Limpach valley, Switzerland. We confirm the importance of geomorphological characteristics for landscape development (hypothesis 1) and our analysis also supports the second hypothesis, which states that changes in demand for certain resources result in landscape change. However, we suggest replacing the term resources by the more encompassing concept of goods and services. The third hypothesis, which states that technological transformations stand at the beginning of landscape change, also was confirmed. Technologies have to be affordable, socially accepted, and corresponding to a demand, to be implemented on a large scale. This will cause a technological transformation, which then—depending on the specifics of the technology applied—becomes relevant for landscape development. We conclude with three reworded hypotheses on driving forces of landscape change and we hope that they will be tested and further developed in other case studie

Probabilistic inverse optimal control with local linearization for non-linear partially observable systems

Inverse optimal control methods can be used to characterize behavior in sequential decision-making tasks. Most existing work, however, requires the control signals to be known, or is limited to fully-observable or linear systems. This paper introduces a probabilistic approach to inverse optimal control for stochastic non-linear systems with missing control signals and partial observability that unifies existing approaches. By using an explicit model of the noise characteristics of the sensory and control systems of the agent in conjunction with local linearization techniques, we derive an approximate likelihood for the model parameters, which can be computed within a single forward pass. We evaluate our proposed method on stochastic and partially observable version of classic control tasks, a navigation task, and a manual reaching task. The proposed method has broad applicability, ranging from imitation learning to sensorimotor neuroscience

Untersuchungen zur Aquiferdynamik im Einzugsgebiet des Blautopfs (Oberjura, Süddeutschland)

Armbruster, V.; Selg, M.: Der Abfluss des Blautopfs im Spiegel der Grundwasserneubildung Bauer, M.; Selg, M.: Altersstruktur und Mittlere Verweilzeit im Grundwasser des Blautopfs und anderer Quellen und Brunnen im Oberjura-Karst Süddeutschlands Selg, M.; Schopper, M.; Straub, R.: Kurzzeitdynamik und Direktabfluss des Blautopf

Safety and efficacy of intravenously administered tedisamil for rapid conversion of recent-onset atrial fibrillation or atrial flutter

AbstractObjectivesThe goal of the present study was to assess the efficacy and safety of intravenous tedisamil, a new antiarrhythmic compound, for conversion of recent-onset atrial fibrillation (AF) or atrial flutter (AFL) to normal sinus rhythm (NSR).BackgroundTedisamil is a novel antiarrhythmic drug with predominantly class III activity. Its efficacy and safety for conversion of recent onset AF or AFL to NSR is not known.MethodsThis was a multicenter, double-blind, randomized, placebo-controlled, sequential ascending dose-group trial. A total of 201 patients with symptomatic AF or AFL of 3 to 48 h duration were enrolled in a two-stage study. During stage 1, patients were randomized to receive tedisamil at 0.4 mg/kg body weight or matching placebo; during stage 2, patients received tedisamil at 0.6 mg/kg body weight or matching placebo. Treatments were given as single intravenous infusions. The primary study end point consisted of the percentage of patients converting to NSR for at least 60 s within 2.5 h.ResultsOf 175 patients representing the intention-to-treat sample, conversion to NSR was observed in 41% (25/61) of the tedisamil 0.4 mg/kg group, 51% (27 of 53) of the tedisamil 0.6 mg/kg group, and 7% (4/59) of the placebo group (p < 0.001 for both tedisamil groups vs. placebo). Average time to conversion was 35 min in patients receiving tedisamil. There were two instances of self-terminating ventricular tachycardia: one episode of torsade de pointes and one of monomorphic ventricular tachycardia, both in patients receiving 0.6 mg/kg tedisamil.ConclusionsTedisamil at dosages of 0.4 and 0.6 mg/kg was superior to placebo in converting AF or AFL. Tedisamil has a rapid onset of action leading to conversion within 30 to 40 min in the majority of responders

Probing Plasmodium falciparum sexual commitment at the single-cell level

Background: Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure. Here we apply single cell transcriptomics to unravel the program inducing sexual differentiation in Plasmodium falciparum. Parasites have to make this essential life-cycle decision in preparation for human-to-mosquito transmission. Methods: By combining transcriptional profiling with quantitative imaging and genetics, we defined a transcriptional signature in sexually committed cells. Results: We found this transcriptional signature to be distinct from general changes in parasite metabolism that can be observed in response to commitment-inducing conditions. Conclusions: This proof-of-concept study provides a template to capture transcriptional diversity in parasite populations containing complex mixtures of different life-cycle stages and developmental programs, with important implications for our understanding of parasite biology and the ongoing malaria elimination campaign

Do pesticide and pathogen interactions drive wild bee declines?

There is clear evidence for wild insect declines globally. Habitat loss, climate change, pests, pathogens and environmental pollution have all been shown to cause detrimental effects on insects. However, interactive effects between these stressors may be the key to understanding reported declines. Here, we review the literature on pesticide and pathogen interactions for wild bees, identify knowledge gaps, and suggest avenues for future research fostering mitigation of the observed declines. The limited studies available suggest that effects of pesticides most likely override effects of pathogens. Bees feeding on flowers and building sheltered nests, are likely less adapted to toxins compared to other insects, which potential susceptibility is enhanced by the reduced number of genes encoding detoxifying enzymes compared with other insect species. However, to date all 10 studies using a fully-crossed design have been conducted in the laboratory on social bees using Crithidia spp. or Nosema spp., identifying an urgent need to test solitary bees and other pathogens. Similarly, since laboratory studies do not necessarily reflect field conditions, semi-field and field studies are essential if we are to understand these interactions and their potential effects in the real-world. In conclusion, there is a clear need for empirical (semi-)field studies on a range of pesticides, pathogens, and insect species to better understand the pathways and mechanisms underlying their potential interactions, in particular their relevance for insect fitness and population dynamics. Such data are indispensable to drive forward robust modelling of interactive effects in different environmental settings and foster predictive science. This will enable pesticide and pathogen interactions to be put into the context of other stressors more broadly, evaluating their relative importance in driving the observed declines of wild bees and other insects. Ultimately, this will enable the development of more effective mitigation measures to protect bees and the ecosystem services they supply

Head kinematics in patients with neck pain compared to asymptomatic controls : a systematic review

Background: Neck pain is one of the most common musculoskeletal disorders encountered by healthcare providers. A precise assessment of functional deficits, including sensorimotor control impairment, is regarded necessary for tailored exercise programmes. Sensorimotor control can be measured by kinematic characteristics, such as velocity, acceleration, smoothness, and temporal measures, or by assessing movement accuracy. This systematic review aims to identify movement tasks and distinct outcome variables used to measure kinematics and movement accuracy in patients with neck pain and present their results in comparison to asymptomatic controls. Methods: Electronic searches were conducted in MEDLINE, PEDro, Cochrane Library and CINAHL databases from inception to August 2020. Risk of bias of included studies was assessed. Movement tasks and specific outcome parameters used were collated. The level of evidence for potential group differences in each outcome variable between patients with neck pain and controls was evaluated. Results: Twenty-seven studies examining head kinematics and movement accuracy during head-aiming, functional and unconstrained movement tasks of the head were included. Average Risk of Bias of included studies was moderate. In total, 23 different outcome variables were assessed. A strong level of evidence for an increased movement time and for an increased number of errors during head aiming tasks was found. Moderate evidence was found in traumatic neck pain for a decreased mean velocity, peak acceleration, and reaction time, and for point deviation and time on target during head aiming tasks. Moderate evidence was found for decreased acceleration during unconstrained movements, too. Results on the remaining movement task and outcome variables showed only limited, very limited or even conflicting level of evidence for patients with neck pain to differ from controls. Conclusions: Sensorimotor control in NP in the way of kinematic and movement accuracy characteristics of head motion was examined in head aiming, functional or unconstrained movement tasks. The results from this review indicate that for some characteristics that describe sensorimotor control, patients with NP differ from healthy controls. Systematic review registration: PROSPERO registration number: CRD42020139083