Unveiling Sources of Heating in the Vicinity of the Orion BN/KL Hot Core as Traced by Highly Excited Inversion Transitions of Ammonia

Using the Expanded Very Large Array, we have mapped the vicinity of the Orion BN/KL Hot Core with sub-arcsecond angular resolution in seven metastable inversion transitions of ammonia: (J,K)=(6,6) to (12,12). This emission comes from levels up to 1500 K above the ground state, enabling identification of source(s) responsible for heating the region. We used this multi-transition dataset to produce images of the rotational/kinetic temperature and the column density of ammonia for ortho and para species separately and on a position-by-position basis. We find rotational temperature and column density in the range 160-490 K and (1-4)x10^17 cm^-2, respectively. Our spatially-resolved images show that the highest (column) density and hottest gas is found in a northeast-southwest elongated ridge to the southeast of Source I. We have also measured the ortho-para ratio of ammonia, estimated to vary in the range 0.9-1.6. Enhancement of ortho with respect to para and the offset of hot ammonia emission peaks from known (proto)stellar sources provide evidence that the ammonia molecules have been released from dust grains into the gas-phase through the passage of shocks and not by stellar radiation. We propose that the combined effect of Source I's proper motion and its low-velocity outflow impinging on a pre-existing dense medium is responsible for the excitation of ammonia and the Orion Hot Core. Finally, we found for the first time evidence of a slow (5 km/s) and compact (1000 AU) outflow towards IRc7.Comment: To appear in Astrophysical Journal Letters Special Issue on the EVLA. 8 pages, 4 figure

Midazolam use for dental conscious sedation: how safe are we?

Aim: To explore the safety awareness of midazolam use amongst dentist in the UK. Materials and methods: A cross-sectional study on 203 dentists was undertaken, 146 of whom currently practice conscious sedation using intravenous midazolam. Use of high strength midazolam; awareness of the Rapid Response Report (RRR) and the National Reporting and Learning System (NRLS); and midazolam related incidents were explored. Results: Formal training in conscious sedation was variable with 35.6% holding a postgraduate sedation qualification. Flumazenil administration was common practice (63%) although used very selectively. Use to reverse respiratory depression was minimal (4%). Awareness of the RRR and the NRLS was generally low but higher among those working in general dental practice (p<0.05). Comparative analysis showed that high dose midazolam was administered more frequently in gastroenterology than in dentistry (p<0.001) with higher incidences of overdose (12.4% Vs 4.8%) and death (8.3% Vs 0%) within a 3 year period. Conclusions: High strength midazolam administration remains prevalent in dentistry, despite recommendations by the DoH. Use of flumazenil for reasons other than respiratory depression in dentistry should warrant little concern. The low incidence of reported harm is positive but may be due to a lack of uptake of national reporting systems

The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort

Background: Estimates of the incidence and prevalence of chronic diseases can be made using established cohort studies but these estimates may have lower reliability if based purely on self-reported diagnosis.Methods: The MRC Cognitive Function & Ageing Study ( MRC CFAS) has collected longitudinal data from a population-based random sample of 13004 individuals over the age of 65 years from 5 centres within the UK. Participants were asked at baseline and after a two-year follow-up whether they had received a diagnosis of Parkinson's disease. Our aim was to make estimates of the incidence and prevalence of PD using self-reporting, and then investigate the validity of self-reported diagnosis using other data sources where available, namely death certification and neuropathological examination.Results: The self-reported prevalence of Parkinson's disease ( PD) amongst these individuals increases with age from 0.7% (95% CI 0.5 - 0.9) for 65 - 75, 1.4% ( 95% CI 1.0 - 1.7) for 75 - 85, and 1.6% ( 95% CI 1.0 - 2.3) for 85+ age groups respectively. The overall incidence of self reported PD in this cohort was 200/100,000 per year ( 95% CI 144 - 278). Only 40% of the deceased individuals reporting prevalent PD and 35% of those reporting incident PD had diagnoses of PD recorded on their death certificates. Neuropathological examination of individuals reporting PD also showed typical PD changes in only 40%, with the remainder showing basal ganglia pathologies causing parkinsonism rather than true PD pathology.Conclusion: Self-reporting of PD status may be used as a screening tool to identify patients for epidemiological study, but inevitably identifies a heterogeneous group of movement disorders patients. Within this group, age, male sex, a family history of PD and reduced cigarette smoking appear to act as independent risk factors for self-reported PD

An HI Imaging Survey of Asymptotic Giant Branch Stars

We present an imaging study of a sample of eight asymptotic giant branch (AGB) stars in the HI 21-cm line. Using observations from the Very Large Array, we have unambiguously detected HI emission associated with the extended circumstellar envelopes of six of the targets. The detected HI masses range from M_HI ~ 0.015-0.055 M_sun. The HI morphologies and kinematics are diverse, but in all cases appear to be significantly influenced by the interaction between the circumstellar envelope and the surrounding medium. Four stars (RX Lep, Y UMa, Y CVn, and V1942 Sgr) are surrounded by detached HI shells ranging from 0.36 to 0.76 pc across. We interpret these shells as resulting from material entrained in a stellar outflow being abruptly slowed at a termination shock where it meets the local medium. RX Lep and TX Psc, two stars with moderately high space velocities (V_space>56 km/s), exhibit extended gaseous wakes (~0.3 and 0.6 pc in the plane of the sky), trailing their motion through space. The other detected star, R Peg, displays a peculiar "horseshoe-shaped" HI morphology with emission extended on scales up to ~1.7 pc; in this case, the circumstellar debris may have been distorted by transverse flows in the local interstellar medium. We briefly discuss our new results in the context of the entire sample of evolved stars that has been imaged in HI to date.Comment: Accepted to AJ. A version with full resolution figures is available at http://www.haystack.mit.edu/hay/staff/lmatthew/matthews_HI_survey.pd

A Documentary of High-Mass Star Formation: Probing the Dynamical Evolution of Orion Source I on 10-100 AU Scales using SiO Masers

A comprehensive picture of high-mass star formation has remained elusive, in part because examples of high-mass YSOs tend to be relatively distant, deeply embedded, and confused with other emission sources. These factors have impeded dynamical investigations within tens of AU of high-mass YSOs--scales that are critical for probing the interfaces where outflows from accretion disks are launched and collimated. Using observations of SiO masers obtained with the VLA and the VLBA, the KaLYPSO project is overcoming these limitations by mapping the structure and dynamical/temporal evolution of the material 10-1000 AU from the nearest high-mass YSO: Radio Source I in the Orion BN/KL region. Our data include ~40 epochs of VLBA observations over a several-year period, allowing us to track the proper motions of individual SiO maser spots and to monitor changes in the physical conditions of the emitting material with time. Ultimately these data will provide 3-D maps of the outflow structure over approximately 30% of the outflow crossing time. Here we summarize recent results from the KaLYPSO project, including evidence that high-mass star formation is occurring via disk-mediated accretion.Comment: 5 pages; to appear in the proceedings of IAU Symposium 242, Astrophysical Masers and their Environments, ed. J. Chapman & W. Baa