Measuring Sizes of Marginally Resolved Young Globular Clusters with HST

We present a method to derive sizes of marginally resolved star clusters from HST/WFPC2 observations by fitting King models to observations. We describe results on both simulated images and on observations of young compact clusters in NGC 3597 and NGC 1275. From the simulations, we find that we can measure King model concentrations (c) to an accuracy of about a factor of two for all combinations of c and King radius (r_0) of interest if the data have high S/N (>~ 500 for the integrated brightness). If the concentration is accurately measured, we can measure the King radius accurately. For lower S/N, marginally resolved King profiles suffer from a degeneracy; different values of the concentration give different r_0 but have comparable reduced chi-squared values. In this case, neither the core radius nor the concentration can be constrained individually, but the half-light radius can be recovered accurately. In NGC 3597, we can only differentiate between concentrations for the very brightest clusters; these suggest a concentration of ~ 2. Assuming a concentration of 2 for the rest of the objects, we find an average King radius for the clusters in NGC 3597 of 0.7 pc, while the clusters in NGC 1275 have an average radius of 1.1 pc. These are similar to the average core radii for Galactic globular clusters, 0.92 pc. We find average half-light radii of 5.4 pc and 6.2 pc for the young clusters in NGC 3597 and NGC 1275, respectively, while the average half-light radii of Galactic globulars is 3.4 pc. The spread in the derived radial parameters in each cluster system is comparable to that observed in the Galactic globular cluster system.Comment: 38 pages, 19 figures, accepted for publication in PAS

Principles for the post-GWAS functional characterisation of risk loci

Several challenges lie ahead in assigning functionality to susceptibility SNPs. For example, most effect sizes are small relative to effects seen in monogenic diseases, with per allele odds ratios usually ranging from 1.15 to 1.3. It is unclear whether current molecular biology methods have enough resolution to differentiate such small effects. Our objective here is therefore to provide a set of recommendations to optimize the allocation of effort and resources in order maximize the chances of elucidating the functional contribution of specific loci to the disease phenotype. It has been estimated that 88% of currently identified disease-associated SNP are intronic or intergenic. Thus, in this paper we will focus our attention on the analysis of non-coding variants and outline a hierarchical approach for post-GWAS functional studies

Nonlinear Krylov Acceleration Applied to a Discrete Ordinates Formulation of the k-Eigenvalue Problem

We compare variants of Anderson Mixing with the Jacobian-Free Newton-Krylov and Broyden methods applied to an instance of the k-eigenvalue formulation of the linear Boltzmann transport equation. We present evidence that one variant of Anderson Mixing finds solutions in the fewest number of iterations. We examine and strengthen theoretical results of Anderson Mixing applied to linear problems.Comment: This final revision includes results of the C5G7-MOX problem; Nonlinear Krylov Acceleration Applied to a Discrete Ordinates Formulation of the k-Eigenvalue Problem, Accepted by the Journal of Computational Physics December 201

Assessing the Educational Quality of Training Videos for Collection of a Nasopharyngeal Swab

Introduction: The SARS-CoV-2 pandemic has forced healthcare systems to disseminate their training materials quickly and broadly, including instruction on identifying cases of infection through correct nasopharyngeal swabbing. Incorrect nasopharyngeal swabbing technique leads to substandard sampling, patient discomfort, and increased risk of complications. We set out to evaluate the quality of educational videos on the nasopharyngeal swab procedure. Methods: Using video search engines, videos on nasopharyngeal swabbing were identified and distributed to two reviewers. The quality of videos was assessed using a scoring system that examined indications, contraindications, personal protective equipment use, swab depth, swab angle, and audiovisual quality. Descriptive statistics and Spearman’s correlation coefficients were utilized to analyze video quality and its association with individual video characteristics. Results: Videos received an average composite score of 5.4 (range: 0-10), with about half of all videos properly discussing and demonstrating the nasopharyngeal swab technique. Over 62% of reviews indicated that the reviewer would not recommend the video to a trainee, with the vast majority identifying improper swab technique as the main factor. There were no statistically significant associations between video score and publication date, number of views, and subscribers to the publisher. Conclusion: Our study shows a glaring lack of quality educational videos on the nasopharyngeal swab procedure. Health care providers should be cautious when using educational videos to learn procedures as popularity may not be associated with accuracy

Non-native vascular flora of the Arctic : Taxonomic richness, distribution and pathways

We present a comprehensive list of non-native vascular plants known from the Arctic, explore their geographic distribution, analyze the extent of naturalization and invasion among 23 subregions of the Arctic, and examine pathways of introductions. The presence of 341 non-native taxa in the Arctic was confirmed, of which 188 are naturalized in at least one of the 23 regions. A small number of taxa (11) are considered invasive; these plants are known from just three regions. In several Arctic regions there are no naturalized non-native taxa recorded and the majority of Arctic regions have a low number of naturalized taxa. Analyses of the non-native vascular plant flora identified two main biogeographic clusters within the Arctic: American and Asiatic. Among all pathways, seed contamination and transport by vehicles have contributed the most to non-native plant introduction in the Arctic.Peer reviewe

Deep Hubble Space Telescope observations of star clusters in NGC 1275

We present an analysis of compact star clusters in deep Hubble Space Telescope Wide Field Planetary Camera 2 images of NGC 1275. B- and R-band photometry of roughly 3000 clusters shows a bimodality in the B-R colors, suggesting that distinct old and young cluster populations are present. The small spread in the colors of the blue clusters is consistent with the hypothesis that they are a single-age population, with an inferred age of 0.1 to 1 Gyr. The luminosity function shows increasing numbers of blue clusters to the limit of our photometry, which reaches several magnitudes past the turnover predicted if the cluster population is identical to current Galactic globular clusters seen at a younger age. The blue clusters have a spatial distribution that is more centrally peaked than that of the red clusters. The individual clusters are slightly resolved, with core radii ≾0.75 pc if they have modified Hubble profiles. We estimate the specific frequencies of the old and young populations and discuss the uncertainties in these estimates. We find that the specific frequency of the young population in NGC 1275 is currently larger than that of the old population and will remain so as the young population evolves, even if the majority of the low-mass clusters are eventually destroyed. If the young population formed during a previous merger, this suggests that mergers can increase the specific frequency of globular clusters in a galaxy. However, the presently observed young population likely contains too few clusters to have a significant impact on the overall specific frequency as it will be observed in the future

Deep Hubble Space Telescope observations of blue star clusters in NGC 3597

We have analyzed HST/WFPC2 images of NGC 3597 and find ~700 compact objects surrounding the galaxy with an average (B-R)_0~0.6. We propose that the majority of these objects are young globular clusters. They have a spread in colors that is consistent with that expected for a population of young clusters with a common age and spread induced by photometric errors and reddening within NGC 3597. If these objects were similar to the Galactic globular cluster system seen at a younger age, we would predict a turnover in the luminosity function at B~23. However, we find that the luminosity function for the clusters is increasing to the limits of our photometry (B~27)

Signals for Lorentz Violation in Electrodynamics

An investigation is performed of the Lorentz-violating electrodynamics extracted from the renormalizable sector of the general Lorentz- and CPT-violating standard-model extension. Among the unconventional properties of radiation arising from Lorentz violation is birefringence of the vacuum. Limits on the dispersion of light produced by galactic and extragalactic objects provide bounds of 3 x 10^{-16} on certain coefficients for Lorentz violation in the photon sector. The comparative spectral polarimetry of light from cosmologically distant sources yields stringent constraints of 2 x 10^{-32}. All remaining coefficients in the photon sector are measurable in high-sensitivity tests involving cavity-stabilized oscillators. Experimental configurations in Earth- and space-based laboratories are considered that involve optical or microwave cavities and that could be implemented using existing technology.Comment: 23 pages REVTe

Lorentz and CPT Violation in Neutrinos

A general formalism is presented for violations of Lorentz and CPT symmetry in the neutrino sector. The effective hamiltonian for neutrino propagation in the presence of Lorentz and CPT violation is derived, and its properties are studied. Possible definitive signals in existing and future neutrino-oscillation experiments are discussed. Among the predictions are direction-dependent effects, including neutrino-antineutrino mixing, sidereal and annual variations, and compass asymmetries. Other consequences of Lorentz and CPT violation involve unconventional energy dependences in oscillation lengths and mixing angles. A variety of simple models both with and without neutrino masses are developed to illustrate key physical effects. The attainable sensitivities to coefficients for Lorentz violation in the Standard-Model Extension are estimated for various types of experiments. Many experiments have potential sensitivity to Planck-suppressed effects, comparable to the best tests in other sectors. The lack of existing experimental constraints, the wide range of available coefficient space, and the variety of novel effects imply that some or perhaps even all of the existing data on neutrino oscillations might be due to Lorentz and CPT violation.Comment: 25 pages REVTe

Deep HST Observations of Star Clusters in NGC 1275

We present an analysis of compact star clusters in deep HST/WFPC2 images of NGC 1275. B and R band photometry of roughly 3000 clusters shows a bimodality in the B-R colors, suggesting that distinct old and young cluster populations are present. The small spread in the colors of the blue clusters is consistent with the hypothesis that they are a single age population, with an inferred age of 0.1 to 1 Gyr. The luminosity function shows increasing numbers of blue clusters to the limit of our photometry, which reaches several magnitudes past the turnover predicted if the cluster population were identical to current Galactic globulars seen at a younger age. The blue clusters have a spatial distribution which is more centrally peaked than that of the red clusters. The individual clusters are slightly resolved, with core radii <~ 0.75 pc if they have modified Hubble profiles. We estimate the specific frequencies of the old and young populations and discuss the uncertainties in these estimates. We find that the specific frequency of the young population in NGC 1275 is currently larger than that of the old population and will remain so as the young population evolves, even if the majority of the low mass clusters are eventually destroyed. If the young population formed during a previous merger, this suggests that mergers can increase the specific frequency of globulars in a galaxy. However, the presently observed young population likely contains too few clusters to have a significant impact on the overall specific frequency as it will be observed in the future.Comment: 26 pages, 9 figures, to be published in the Astronomical Journa