Research Framework for Consumer Satisfaction with Internet Shopping

Consumer satisfaction with Internet shopping has been conceptualized in a variety of ways. Studies in this area remain broad and appear relatively fragmented. In view of this, the purpose of this study is to propose a research framework that integrates both end-user computing satisfaction literature and service quality literature. This framework explicitly considers information quality, system quality, and service quality as the key dimensions of consumer satisfaction with Internet shopping. We believe the research framework and propositions serve as salient guidelines for researchers

A new family of AdS4AdS_4 S-folds in type IIB string theory

We construct infinite new classes of $AdS_4\times S^1\times S^5$ solutions of type IIB string theory which have non-trivial $SL(2,\mathbb{Z})$ monodromy along the $S^1$ direction. The solutions are supersymmetric and holographically dual, generically, to $\mathcal{N}=1$ SCFTs in $d=3$. The solutions are first constructed as $AdS_4\times \mathbb{R}$ solutions in $D=5$ $SO(6)$ gauged supergravity and then uplifted to $D=10$. The solutions all arise as limiting cases of Janus solutions of $d=4$, $\mathcal{N}=4$ SYM theory which are supported both by a different value of the coupling constant on either side of the interface, as well as by fermion and boson mass deformations. As special cases, the construction recovers three known S-fold constructions, which preserve $\mathcal{N}=1,2$ and 4 supersymmetry, as well as a recently constructed $\mathcal{N}=1$ $AdS_4\times S^1\times S^5$ solution (not S-folded). We also present some novel "one-sided Janus" solutions that are non-singular.Comment: 54 pages, 13 figure

Core and skin temperature influences on the surface electromyographic responses to an isometric force and position task

<p><b>Electromyographic responses of root-mean-square amplitude (RMS; A), mean power frequency (MPF; B) and median power frequency (MDF; C) to passive heating and cooling for the 1-minute isometric force (black bars) and position (open bars) task in 18 participants.</b> Temperature states: initial T_re and (BASE); hot T_re, hot (H-H); hot T_re, cool (H-C); and end of the protocol where T_re returned to normal and was cool (POST). ^aSignificantly different from baseline (BASE). ^bSignificantly different from hot core-hot skin (H-H). ^cSignificantly different from hot core-cool skin(H-C). ^dSignificantly different from end of protocol (POST).</p

A Dual-Identity Perspective of Obsessive Online Social Gaming

Obsessive online social gaming has become a worldwide societal challenge that deserves more scholarly investigation. However, this issue has not received much attention in the information systems (IS) research community. Guided by dual-system theory, we theoretically derive a typology of obsessive technology use and contextually adapt it to conceptualize obsessive online social gaming. We also build upon identity theory to develop a dual-identity perspective (i.e., IT identity and social identity) of obsessive online social gaming. We test our research model using a longitudinal survey of 627 online social game users. Our results demonstrate that the typology of obsessive technology use comprises four interrelated types: impulsive use, compulsive use, excessive use, and addictive use. IT identity positively affects the four obsessive online social gaming archetypes and fully mediates the effect of social identity on obsessive online social gaming. The results also show that IT identity is predicted by embeddedness, self-efficacy, and instant gratification, whereas social identity is determined by group similarity, group familiarity, and intragroup communication. Our study contributes to the IS literature by proposing a typology of obsessive technology use, incorporating identity theory to provide a contextualized explanation of obsessive online social gaming and offering implications for addressing the societal challenge

CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype.

Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States, whereas colorectal cancer is the third most common cancer. The RNA-binding protein HuR (ELAVL1) supports a pro-oncogenic network in gastrointestinal (GI) cancer cells through enhanced HuR expression. Using a publically available database, HuR expression levels were determined to be increased in primary PDA and colorectal cancer tumor cohorts as compared with normal pancreas and colon tissues, respectively. CRISPR/Cas9 technology was successfully used to delete the HuR gene in both PDA (MIA PaCa-2 and Hs 766T) and colorectal cancer (HCT116) cell lines. HuR deficiency has a mild phenotype

Key Articles, Guidelines, and Consensus Papers Relative to the Treatment of Dyslipidemias—2005

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90074/1/phco.26.7.939.pd

Searching for the light dark gauge boson in GeV-scale experiments

We study current constraints and search prospects for a GeV scale vector boson at a range of low energy experiments. It couples to the Standard Model charged particles with a strength <= 10^-3 to 10^-4 of that of the photon. The possibility of such a particle mediating dark matter self-interactions has received much attention recently. We consider searches at low energy high luminosity colliders, meson decays, and fixed target experiments. Based on available data, searches both at colliders and in meson decays can discover or exclude such a scenario if the coupling strength is on the larger side. We emphasize that a dedicated fixed target experiment has a much better potential in searching for such a gauge boson, and outline the desired properties of such an experiment. Two different optimal designs should be implemented to cover the range of coupling strength 10^-3 to 10^-5, and < 10^-5 of the photon, respectively. We also briefly comment on other possible ways of searching for such a gauge boson.Comment: 33 pages, 5 figures; v2: corrected discussion of Upsilon decays, updates to discussion of fixed-target experiments and QED constraints, numerous minor changes, references added; v3: typo corrected relative to the JHEP published versio

Environmental Forensic Characterization of Former Rail Yard Soils Located Adjacent to the Statue of Liberty in the New York/New Jersey Harbor

Identifying inorganic and organic soil contaminants in urban brownfields can give insights into the adverse effects of industrial activities on soil function, ecological health, and environmental quality. Liberty State Park in Jersey City (N.J., USA) once supported a major rail yard that had dock facilities for both cargo and passenger service; a portion remains closed to the public, and a forest developed and spread in this area. The objectives of this study were to: 1) characterize the organic and inorganic compounds in Liberty State Park soils and compare the findings to an uncontaminated reference site (Hutcheson Memorial Forest); and 2) identify differences between the barren low-functioning areas and the forested high-functioning areas of the brownfield. Soil samples were solvent-extracted, fractionated, and analyzed by gas chromatography–mass spectrometry and subjected to loss-on-ignition, pyrolysis-gas chromatography–mass spectrometry, inductively-coupled-plasma mass spectrometry, and optical microscopy analyses. Compared to soil from the reference site, the forested soils in Liberty State Park contained elevated percentages of organic matter (30–45%) and more contaminants, such as fossil-fuel-derived hydrocarbons and coal particles. Microscopy revealed bituminous and anthracite coal, coke, tar/pitch, and ash particles. Barren and low-functioning site 25R had a similar organic contaminant profile but contained a higher metal load than other Liberty State Park sites and also lacked higher plant indicators. These can obscure the signatures of contaminants, and data from adjacent barren and vegetated sites are valuable references for soils studies. A deeper understanding of the chemistry, biochemistry, and ecology of barren soils can be leveraged to prevent land degradation and to restore dysfunctional and phytotoxic soils