A Review of the Evidence Supporting the Taste of Non‐esterified Fatty Acids in Humans

Dietary fats contribute to the flavor of foods by multiple mechanisms. A role for their taste has only recently gained credence. Current evidence indicates non‐esterified fatty acids (NEFA) are the effective stimuli for the taste component. CD36 and GPR120 are putative receptors, but may not fully account for the totality of the range of sensations elicited by fatty acids. The sensory quality of long‐chain NEFA is not adequately characterized by commonly accepted taste primary qualities and has been termed oleogustus. There is marked individual variability in sensitivity to the taste of NEFA prompting hypotheses of genetic and environmental determinants. Though an association with BMI has been proposed, the preponderance of evidence is not supportive. The importance of oleogustus has not been fully established, but likely contributes to flavor, which influences food choice as well as lipid metabolism and chronic disease risk. A better understanding of oleogustus may provide insights useful for product formulation

Smell you later - the repelling effect of secondary plant compounds against water voles and common voles

Fischer, D., Prokop, A., Wink, M., Mattes, H., Jacob, J

Multiskilled Health Practitioners: Results of a Graduate Assessment

To ascertain the assimilation of graduates into multiskilled practice, the Add-A-Comp Program, Methodist Hospital of Indiana, conducted an assessment of graduates over a 30-month period. Input was received both from the program’s graduates and supervisors of the graduates. Of the 40 responding graduates, 24 (60%) had functioned in a multiskilled capacity. The majority of graduates reported increased job satisfaction, security, challenge, opportunities, and perceived value to their employer resulting from their multiskilled employment, with 58% receiving additional compensation for multiskilled functioning. Of the 24 supervisor respondents, 92% felt that their multiskilled graduates’ knowledge and competency levels had met their expectations and that the sponsorship was worth the investment. Many of the Add-A-Comp modules utilize a self-directed learning packet approach with 92% of graduates using these packets indicating an excellent or satisfactory rating for this instructional method

Ferroelectricity in the xAg2Nb4O11–(1−x)Na2Nb4O11 solid solution

Compositions in the (AgxNa1-x)2Nb4O11 solid solution have been prepared by a conventional solid state method. Composites containing Ag2Nb4O11 have been shown to be ferroelectric and the Curie temperature shown to decrease from 149 °C at x = 1 to 62 °C at x = 0.7. Roomtemperature compositions with x ≤ 0.7 are monoclinic, while those with x ≥ 0.8 are rhombohedral with structures consistent with the relevant end-members. At x = 0.75, the structure was mainly rhombohedral but with coexistence of the monoclinic structure, indicating the proximity of a phase boundary

Minor Histocompatibility Antigen DBY Elicits a Coordinated B and T Cell Response after Allogeneic Stem Cell Transplantation

We examined the immune response to DBY, a model H-Y minor histocompatibility antigen (mHA) in a male patient with chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplant from a human histocompatibility leukocyte antigen (HLA)-identical female sibling. Patient peripheral blood mononuclear cells were screened for reactivity against a panel of 93 peptides representing the entire amino acid sequence of DBY. This epitope screen revealed a high frequency CD4(+) T cell response to a single DBY peptide that persisted from 8 to 21 mo after transplant. A CD4(+) T cell clone displaying the same reactivity was established from posttransplant patient cells and used to characterize the T cell epitope as a 19-mer peptide starting at position 30 in the DBY sequence and restricted by HLA-DRB1*1501. Remarkably, the corresponding X homologue peptide was also recognized by donor T cells. Moreover, the T cell clone responded equally to mature HLA-DRB1*1501 male and female dendritic cells, indicating that both DBY and DBX peptides were endogenously processed. After transplant, the patient also developed antibodies that were specific for recombinant DBY protein and did not react with DBX. This antibody response was mapped to two DBY peptides beginning at positions 118 and 536. Corresponding DBX peptides were not recognized. These studies provide the first demonstration of a coordinated B and T cell immune response to an H-Y antigen after allogeneic transplant. The specificity for recipient male cells was mediated by the B cell response and not by donor T cells. This dual DBX/DBY antigen is the first mHA to be identified in the context of chronic GVHD

Analyse und Untersuchung der Quantisierungseffekte beim Goertzel-Filter

Digitale Filter können in praktischen Anwendungen nur mit endlicher Wortbreite realisiert werden. Deshalb müssen Quantisierungseffekte verstanden werden, um die Eigenschaften und die Performanz der digitalen Filter geeignet einstellen zu können. Die am stärksten beeinflussten Aspekte sind neben Frequenzgang, die Stabilität und das Signal-Rausch-Verhältnis. Zu geringe Wortbreiten führen zu drastischen Veränderungen der Filtereigenschaften. Eine zu konservativ gewählte Wortbreite hingegen, erhöht die Größe und somit die Anzahl der Operationen des Filters unnötigerweise. Ziel dieses Beitrages ist es, für eine bestimmte Filterklasse optimale Wortbreiten zu finden, welche sowohl die Anzahl der Berechnungen und damit Operationen minimieren als auch sicherstellen, dass vorgegebene Toleranzbereiche für spezifizierte Filtereigenschaften eingehalten werden können. Die Untersuchungen werden an einem Goertzel-Filter durchgeführt, welches aufgrund seiner effizienten Eigenschaften besonders für die spektrale Bewertung von Mixed-Signal Schaltungen und Systemen geeignet ist

Secreted Frizzled-related Protein 2 (sFRP2) Redirects Non-canonical Wnt Signaling from Fz7 to Ror2 during Vertebrate Gastrulation

This is the final version of the article. Available from American Society for Biochemistry and Molecular Biology via the DOI in this record.Convergent extension movements during vertebrate gastrulation require a balanced activity of non-canonical Wnt signaling pathways, but the factors regulating this interplay on the molecular level are poorly characterized. Here we show that sFRP2, a member of the secreted frizzled-related protein (sFRP) family, is required for morphogenesis and papc expression during Xenopus gastrulation. We further provide evidence that sFRP2 redirects non-canonical Wnt signaling from Frizzled 7 (Fz7) to the receptor tyrosine kinase-like orphan receptor 2 (Ror2). During this process, sFRP2 promotes Ror2 signal transduction by stabilizing Wnt5a-Ror2 complexes at the membrane, whereas it inhibits Fz7 signaling, probably by blocking Fz7 receptor endocytosis. The cysteine-rich domain of sFRP2 is sufficient for Ror2 activation, and related sFRPs can substitute for this function. Notably, direct interaction of the two receptors via their cysteine-rich domains also promotes Ror2-mediated papc expression but inhibits Fz7 signaling. We propose that sFRPs can act as a molecular switch, channeling the signal input for different non-canonical Wnt pathways during vertebrate gastrulation

Concerning the Phases of Annual Variations of Nuclear Decay Rates

Recent analyses of datasets acquired at the Brookhaven National Laboratory and at the Physikalisch-Technische Bundesanstalt both show evidence of pronounced annual variations, suggestive of a solar influence. However, the phases of decay-rate maxima do not correspond precisely to the phase of minimum Sun-Earth distance, as might then be expected. We here examine the hypothesis that decay rates are influenced by an unknown solar radiation, but that the intensity of the radiation is influenced not only by the variation in Sun-Earth distance, but also by a possible North-South asymmetry in the solar emission mechanism. We find that this can lead to phases of decay-rate maxima in the range 0 to 0.183 or 0.683 to 1 (September 6 to March 8) but that, according to this hypothesis, phases in the range 0.183 to 0.683 (March 8 to September 6) are "forbidden." We find that phases of the three datasets here analyzed fall in the allowed range.Comment: 5 Pages, 5 Figure