Allylic and Allenylic Dearomatization of Indoles promoted by Graphene Oxide via Covalent Grafting Activation Mode

The site‐selective allylative and allenylative dearomatization of indoles with alcohols is performed under carbocatalytic regime in the presence of graphene oxide (GO, 10 wt% loading) as the promoter. Metal‐free conditions, absence of stoichiometric additive, environmentally friendly conditions (H2O/CH3CN, 55 \ub0C, 6 h), broad substrate scope (33 examples, yield up to 92%) and excellent site‐ and stereoselectivity characterize the present methodology. Moreover, a covalent activation model exerted by GO functionalities was corroborated by spectroscopic, experimental and computational evidences. Recovering and regeneration of the GO catalyst via simple acidic treatment was also documented

Power Over Fibre Systems for the Italian SKA-Low Demonstrators

The Power over Fibre technique allows to power remote electronics without using copper cables. Avoiding any interaction between the antenna and its power/signal cable is attractive in the case of testing systems where the evaluation of antenna and/or array performance are crucial parameters under investigation. This is the case of the Sardina Array Demonstrator, an Italian SKA testing platform. In this work is evaluated the applicability of this technology in order to power the electronics of the antennas which will form SAD. The results of an extensive measurement campaign, with respect to both temperature and fibre length, of commercial PoF receivers, is here presented

Real-life comparison of Pirfenidone and Nintedanib in patients with Idiopathic Pulmonary Fibrosis: a 24-month assessment.

Background: Real-life data on the use of pirfenidone and nintedanib to treat patients with idiopathic pulmonary fibrosis (IPF) are still scarce. Methods: We compared the efficacy of either pirfenidone (n=78) or nintedanib (n=28) delivered over a 24-month period in patients with IPF, followed at two regional clinic centers in Italy, with a group of patients who refused the treatment (n=36), and who were considered to be controls. All patients completed regular visits at 1- to 3-month intervals, where primary [forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO)] and secondary outcomes (side effects, treatment compliance, and mortality) were recorded. Results: Over time, the decline in FVC and DLCO was significantly higher (p=0.0053 and p=0.037, respectively) in controls when compared with the combined treated group, with no significant difference between the two treated groups. Compared to patients with less advanced disease (GAP (Gender, Age, Physiology) stage I), those in GAP stages II and III showed a significantly higher decline in both FVC and DLCO irrespective of the drug taken. Side effects were similarly reported in patients receiving pirfenidone and nintedanib (5% and 7%, respectively), whereas mortality did not differ among the three groups. Conclusion: This real-life study demonstrated that both pirfenidone and nintedanib were equally effective in reducing the decline of FVC and DLCO versus non-treated patients after 24 months of treatment; however, patients with more advanced disease were likely to show a more rapid decline in respiratory function

Efficacy of radioembolization according to tumor morphology and portal vein thrombosis in intermediate–advanced hepatocellular carcinoma

Purpose: We analyzed overall survival (OS) following radioembolization according to macroscopic growth pattern (nodular vs infiltrative) and vascular invasion in intermediate-advanced hepatocellular carcinoma (HCC). Methods: Between September 2005 and November 2013, 104 patients (50.0% portal vein thrombosis [PVT], 29.8% infiltrative morphology) were treated. Results: Median OS differed significantly between patients with segmental and lobar or main PVT (p = 0.031), but was 17 months in both those with patent vessels and segmental PVT. Median OS did not differ for infiltrative and nodular HCC. Median OS was prolonged in patients with a treatment response at 3 months (p = 0.023). Prior TACE was also a significant predictor of improved OS. Conclusion: A further indication for radioembolization might be infiltrative HCC, since OS was similar to nodular types

Charting the Galactic acceleration field II. A global mass model of the Milky Way from the STREAMFINDER Atlas of Stellar Streams detected in Gaia DR3

We present an atlas and follow-up spectroscopic observations of 87 thin stream-like structures detected with the STREAMFINDER algorithm in Gaia DR3, of which 29 are new discoveries. Here we focus on using these streams to refine mass models of the Galaxy. Fits with a double power law halo with the outer power law slope set to $-\beta_h=3$ yield an inner power law slope $-\gamma_h=0.97^{+0.17}_{-0.21}$, a scale radius of $r_{0, h}=14.7^{+4.7}_{-1.0}$ kpc, a halo density flattening $q_{m, h}=0.75\pm0.03$, and a local dark matter density of $\rho_{h, \odot}=0.0114\pm0.0007 {\rm M_\odot pc^{-3}}$. Freeing $\beta$ yields $\beta=2.53^{+0.42}_{-0.16}$, but this value is heavily influenced by our chosen virial mass limit. The stellar disks are found to have a combined mass of $4.20^{+0.44}_{-0.53}\times10^{10} {\rm M_\odot}$, with the thick disk contributing $12.4\pm0.7$\% to the local stellar surface density. The scale length of the thin and thick disks are $2.17^{+0.18}_{-0.08}$ kpc and $1.62^{+0.72}_{-0.13}$ kpc, respectively, while their scale heights are $0.347^{+0.007}_{-0.010}$ kpc and $0.86^{+0.03}_{-0.02}$ kpc, respectively. The virial mass of the favored model is $M_{200}=1.09^{+0.19}_{-0.14}\times 10^{12} {\rm M_\odot}$, while the mass inside of 50 kpc is $M_{R<50}=0.46\pm0.03\times 10^{12} {\rm M_\odot}$. We introduce the Large Magellanic Cloud (LMC) into the derived potential models, and fit the "Orphan" stream therein, finding a mass for the LMC that is consistent with recent estimates. Some highlights of the atlas include the nearby trailing arm of $\omega$-Cen, and a nearby very metal-poor stream that was once a satellite of the Sagittarius dwarf galaxy. Finally, we unambiguously detect a hot component around the GD-1 stream, consistent with it having been tidally pre-processed within its own DM subhalo.Comment: 43 pages, 26 figures, submitted to Ap

A real-time KLT implementation for radio-SETI applications

SETI, the Search for ExtraTerrestrial Intelligence, is the search for radio signals emitted by alien civilizations living in the Galaxy. Narrow-band FFT-based approaches have been preferred in SETI, since their computation time only grows like N*lnN, where N is the number of time samples. On the contrary, a wide-band approach based on the Kahrunen-Lo`eve Transform (KLT) algorithm would be preferable, but it would scale like N*N. In this paper, we describe a hardware-software infrastructure based on FPGA boards and GPU-based PCs that circumvents this computation-time problem allowing for a real-time KLT

Current drive at plasma densities required for thermonuclear reactors

Progress in thermonuclear fusion energy research based on deuterium plasmas magnetically confined in toroidal tokamak devices requires the development of efficient current drive methods. Previous experiments have shown that plasma current can be driven effectively by externally launched radio frequency power coupled to lower hybrid plasma waves. However, at the high plasma densities required for fusion power plants, the coupled radio frequency power does not penetrate into the plasma core, possibly because of strong wave interactions with the plasma edge. Here we show experiments performed on FTU (Frascati Tokamak Upgrade) based on theoretical predictions that nonlinear interactions diminish when the peripheral plasma electron temperature is high, allowing significant wave penetration at high density. The results show that the coupled radio frequency power can penetrate into high-density plasmas due to weaker plasma edge effects, thus extending the effective range of lower hybrid current drive towards the domain relevant for fusion reactors

Corrigendum: Current drive at plasma densities required for thermonuclear reactors

Nature Communications 1: Article number: 55 (2010); Published: 10 August 2010; Updated:19 September 2013. In Fig. 3 of this Article, the colours of the blue and green curves were accidentally interchanged while the manuscript was being revised. In addition, the x axis labels on Fig. 4 should have read 'Frequency (MHz)'

Italian Guidelines in diagnosis and treatment of alopecia areata

Alopecia areata (AA) is an organ-specific autoimmune disorder that targets anagen phase hair follicles. The course is unpredictable and current available treatments have variable efficacy. Nowadays, there is relatively little evidence on treatment of AA from well-designed clinical trials. Moreover, none of the treatments or devices commonly used to treat AA are specifically approved by the Food and Drug Administration. The Italian Study Group for Cutaneous Annexial Disease of the Italian Society of dermatology proposes these Italian guidelines for diagnosis and treatment of Alopecia Areata deeming useful for the daily management of the disease. This article summarizes evidence-based treatment associated with expert-based recommendations

Sardinia Array Demonstrator: Instrument Overview and Status

In the framework of the Square Kilometer Array (SKA) project, the Italian Institute for Astrophysics (INAF) has addressed several efforts in the design and prototyping of aperture arrays for low-frequency radio astronomical research. The Sardinia Array Demonstrator (SAD) is a national project aimed to develop know-how in this area and to test different architectural technologies and calibration algorithms. SAD consists of 128 prototypical dual-polarized Vivaldi antennas designed to operate at radio frequencies below 650 MHz. The antennas will be deployed at the Sardinia Radio Telescope’s site with a versatile approach able to provide two different array configurations: (i) all antennas grouped in one large station or (ii) spread among a core plus few satellite stations. This paper provides an overview of the SAD project from an instrumental point of view, and illustrates its status after 2 years from its start