Excitation of Giant Monopole Resonance in 208^{208}Pb and 116^{116}Sn Using Inelastic Deuteron Scattering

The excitation of the isoscalar giant monopole resonance (ISGMR) in $^{116}$Sn and $^{208}$Pb has been investigated using small-angle (including $0^\circ$) inelastic scattering of 100 MeV/u deuteron and multipole-decomposition analysis (MDA). The extracted strength distributions agree well with those from inelastic scattering of 100 MeV/u $\alpha$ particles. These measurements establish deuteron inelastic scattering at E$_d \sim$ 100 MeV/u as a suitable probe for extraction of the ISGMR strength with MDA, making feasible the investigation of this resonance in radioactive isotopes in inverse kinematics.Comment: 5 pages, 4 figures. To be published in Phys. Lett.

Testing the Mutually Enhanced Magicity Effect in Nuclear Incompressibility via the Giant Monopole Resonance in the 204,206,208^{204,206,208}Pb Isotopes

Using inelastic $\alpha$-scattering at extremely forward angles, including $0^\circ$, the strength distributions of the isoscalar giant monopole resonance (ISGMR) have been measured in the $^{204,206,208}$Pb isotopes in order to examine the proposed mutually enhanced magicity (MEM) effect on the nuclear incompressibility. The MEM effect had been suggested as a likely explanation of the "softness" of nuclear incompressibility observed in the ISGMR measurements in the Sn and Cd isotopes. Our experimental results rule out any manifestation of the MEM effect in nuclear incompressibility and leave the question of the softness of the open-shell nuclei unresolved still.Comment: Accepted for publication in Physics Letters B. Very minor changes in tex

Are There Nuclear Structure Effects on the Isoscalar Giant Monopole Resonance and Nuclear Incompressibility near A~90?

"Background-free" spectra of inelastic $\alpha$-particle scattering have been measured at a beam energy of 385 MeV in $^{90, 92}$Zr and $^{92}$Mo at extremely forward angles, including 0$^{\circ}$. The ISGMR strength distributions for the three nuclei coincide with each other, establishing clearly that nuclear incompressibility is not influenced by nuclear shell structure near $A\sim$90 as was claimed in recent measurements.Comment: 5 pages, 4 figures; accepted for publication in Phys. Lett.

Isoscalar Giant Monopole, Dipole, and Quadrupole Resonances in 90,92^{90,92}Zr and 92^{92}Mo

The isoscalar giant monopole, dipole, and quadrupole strength distributions have been deduced in $^{90, 92}$Zr, and $^{92}$Mo from "background-free" spectra of inelastic $\alpha$-particle scattering at a beam energy of 385 MeV at extremely forward angles, including 0$^{\circ}$. These strength distributions were extracted by a multipole-decomposition analysis based on the expected angular distributions of the respective multipoles. All these strength distributions for the three nuclei practically coincide with each other, affirming that giant resonances, being collective phenomena, are not influenced by nuclear shell structure near $A\sim$90, contrary to the claim in a recent measurement.Comment: 12 pages, 12 figures; Accepted for publication in Phys. Rev. C. arXiv admin note: text overlap with arXiv:1607.0219

In-beam spectroscopy of medium- and high-spin states in 133^{133}Ce

Medium and high-spin states in $^{133}$Ce were investigated using the $^{116}$Cd($^{22}$Ne, $5n$) reaction and the Gammasphere array. The level scheme was extended up to an excitation energy of $\sim22.8$ MeV and spin 93/2 . Eleven bands of quadrupole transitions and two new dipole bands are identified. The connections to low-lying states of the previously known, high-spin triaxial bands were firmly established, thus fixing the excitation energy and, in many cases, the spin parity of the levels. Based on comparisons with cranked Nilsson-Strutinsky calculations and tilted axis cranking covariant density functional theory, it is shown that all observed bands are characterized by pronounced triaxiality. Competing multiquasiparticle configurations are found to contribute to a rich variety of collective phenomena in this nucleus.Comment: 20 pages, 11 figure

Evidence for Multiple Chiral Doublet Bands in 133^{133}Ce

Two distinct sets of chiral-partner bands have been identified in the nucleus $^{133}$Ce. They constitute a multiple chiral doublet (M$\chi$D), a phenomenon predicted by relativistic mean field (RMF) calculations and observed experimentally here for the first time. The properties of these chiral bands are in good agreement with results of calculations based on a combination of the constrained triaxial RMF theory and the particle-rotor model.Comment: Minor changes based on referee reviews and corrections of some typo

Integrated engineering environments for large complex products

An introduction is given to the Engineering Design Centre at the University of Newcastle upon Tyne, along with a brief explanation of the main focus towards large made-to-order products. Three key areas of research at the Centre, which have evolved as a result of collaboration with industrial partners from various sectors of industry, are identified as (1) decision support and optimisation, (2) design for lifecycle, and (3) design integration and co-ordination. A summary of the unique features of large made-to-order products is then presented, which includes the need for integration and co-ordination technologies. Thus, an overview of the existing integration and co-ordination technologies is presented followed by a brief explanation of research in these areas at the Engineering Design Centre. A more detailed description is then presented regarding the co-ordination aspect of research being conducted at the Engineering Design Centre, in collaboration with the CAD Centre at the University of Strathclyde. Concurrent Engineering is acknowledged as a strategy for improving the design process, however design coordination is viewed as a principal requirement for its successful implementation. That is, design co-ordination is proposed as being the key to a mechanism that is able to maximise and realise any potential opportunity of concurrency. Thus, an agentoriented approach to co-ordination is presented, which incorporates various types of agents responsible for managing their respective activities. The co-ordinated approach, which is implemented within the Design Co-ordination System, includes features such as resource management and monitoring, dynamic scheduling, activity direction, task enactment, and information management. An application of the Design Co-ordination System, in conjunction with a robust concept exploration tool, shows that the computational design analysis involved in evaluating many design concepts can be performed more efficiently through a co-ordinated approach

Role of microRNAs (miRNAs) in the pathophysiology of Diabetes mellitus

© 2017 EDIZIONI MINERVA MEDICA. Diabetes mellitus is becoming the critical problem among the entire world and it is difficult to understand the molecular mechanism representing the concept of diabetic pathology. Recently the knowledge of the involvement of genetics in type 2 diabetes mellitus (T2DM) susceptibility has sketched a great concentration towards the transcriptional activity of β cells within the pancreas. This disease becomes the leading cause of death, so it is necessary to study the molecular pathogenesis, phenotypes, and characteristics to design the therapeutic parameters. Here in this review role of miRNA is being illustrated as it plays a crucial role in the pathogenesis, progression, and fate of beta cells of pancreas regulating the insulin secretion. Here in this review, we try to include the effects and pathophysiology of various miRNA in diabetes mellitus and on the various sites of the human body

Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells.

Wnt5a can activate Rho GTPases in chronic lymphocytic leukemia (CLL) cells by inducing the recruitment of ARHGEF2 to ROR1. Mass spectrometry on immune precipitates of Wnt5a-activated ROR1 identified 14-3-3ζ, which was confirmed by co-immunoprecipitation. The capacity of Wnt5a to induce ROR1 to complex with 14-3-3ζ could be blocked in CLL cells by treatment with cirmtuzumab, a humanized mAb targeting ROR1. Silencing 14-3-3ζ via small interfering RNA impaired the capacity of Wnt5a to: (1) induce recruitment of ARHGEF2 to ROR1, (2) enhance in vitro exchange activity of ARHGEF2 and (3) induce activation of RhoA and Rac1 in CLL cells. Furthermore, CRISPR/Cas9 deletion of 14-3-3ζ in ROR1-negative CLL cell-line MEC1, and in MEC1 cells transfected to express ROR1 (MEC1-ROR1), demonstrated that 14-3-3ζ was necessary for the growth/engraftment advantage of MEC1-ROR1 over MEC1 cells. We identified a binding motif (RSPS857SAS) in ROR1 for 14-3-3ζ. Site-directed mutagenesis of ROR1 demonstrated that serine-857 was required for the recruitment of 14-3-3ζ and ARHGEF2 to ROR1, and activation of RhoA and Rac1. Collectively, this study reveals that 14-3-3ζ plays a critical role in Wnt5a/ROR1 signaling, leading to enhanced CLL migration and proliferation