Evolutionary Robotics: a new scientific tool for studying cognition

We survey developments in Artificial Neural Networks, in Behaviour-based Robotics and Evolutionary Algorithms that set the stage for Evolutionary Robotics in the 1990s. We examine the motivations for using ER as a scientific tool for studying minimal models of cognition, with the advantage of being capable of generating integrated sensorimotor systems with minimal (or controllable) prejudices. These systems must act as a whole in close coupling with their environments which is an essential aspect of real cognition that is often either bypassed or modelled poorly in other disciplines. We demonstrate with three example studies: homeostasis under visual inversion; the origins of learning; and the ontogenetic acquisition of entrainment

Home and Business Energy Reduction

Course Code: ENR/AEDE 4567The focus of our project is to reduce energy consumption community-wide by 20% over the next five years within the residential and commercial sectors. This 20% reduction is a goal within Green Memo III, set forth by the City of Columbus and Mayor Michael B. Coleman. Focusing on five objectives, we conducted research, gathered data on best practices from cities that have been making strides in this area, reached out to key energy providers, and provided a cost-benefit analysis on the financial feasibility of our goals. We hope to advise Columbus decision makers on how to effectively target homes and commercial buildings in order to market energy efficiency programs. We believe these programs will effectively reduce overall energy consumption and greenhouse gas (GHG) emissions for the City of Columbus.Academic Major: Environment, Economy, Development, and Sustainabilit

ORS Responsive Manufacturing 6U Spacecraft

The Operationally Responsive Space Office is developing a small satellite capability and small satellite design specifically for advanced manufacturing and assembly methods for a semi-automated assembly and test facility. Designing a small satellite to be assembled and tested with this novel and innovative approach enables reduced costs, schedule, and risk. This presentation will discuss the implementation, unique design features, lessons learned, and challenges associated with developing for this new rapid-assembly capability as well as the unique benefits and challenges of assembly and test using automated, robotic systems. The presentation will also include discussions of the role that design-for-manufacturing, modular open system architecture, componentized subsystems, and standardized interfaces each play in developing the spacecraft. Assembly processes, ground support interfaces, and other assembly, integration and test needs will also be discussed

Business Games for Environment, Sustainability and Governance (ESG)

No abstract available

Testing the methodological utility of trace element analysis for detetecting dietary differences in fossil fauna from Turkana

International audienc

Early adoption in an agile online teaching environment: an intrapreneurial perspective

The Covid-19 pandemic has blown through the Higher Education sector like a Schumpterian ‘gale of creative destruction’ (Schumpeter, 1934), accelerating the pace of change, disrupting entrenched pedagogical approaches, and revealing glimpses of the future of teaching. This study identifies how university-based early adopters responded to this ‘gale,’ successfully implementing the rapid change required to pivot to online teaching while addressing institutional requests to support the reluctant majority. Adopting an innovative interdisciplinary framework, this study advances understanding about the criticality of early-adopter behaviour in implementing change. The triggers, dynamics and impact of early-adopter behaviours are identified, as are the resultant implications for institutions for resourcing, recognising, and rewarding early adopters. The research design is underpinned by polyphony (Belova, 2010). Theoretical aspects from entrepreneurship (Stevenson, Roberts & Grousebeck, 1989) and networked learning (Dohn, Cranmer, Sime, De Laat & Ryberg, 2018) are also incorporated, relating early adopter behaviour to the entrepreneurial process in the context of virtual learning communities. This study uses vignettes from early adopters who have pivoted to online teaching in a university, identifying their experiences of instigating and supporting change. The findings highlight the facilitators of, and constraints on, early adopter behaviour, identifying the contextual characteristics necessary to challenge preconceived institutional notions and develop intrapreneurial mindsets that more readily support and implement early-adopter behaviours

Making it in the Modern Job Market: A Study of Communication among the Deaf and Hard of Hearing Population

Gemstone Team AUDIO (Assessing and Understanding Deaf Individuals' Occupations)Due to the increasing importance of communication in the professional world, deaf and hard of hearing individuals are being marginalized in the job market through employment opportunities and salary. The purpose of the research study was to investigate the significance of the communication barrier further. The two research questions the team focused on were: (1) Are the communication skills further developed by deaf and hard of hearing students at mainstream universities comparable to those of deaf and hard of hearing students at specialized universities? (2) How does attending a mainstream versus a specialized university prepare a deaf individual to communicate through written and oral communication skills? In the first portion of the study, the team distributed an original online survey to obtain demographic data, as well as a sample of written communication skills. In phase two, the team conducted video-taped interviews. Both written and inter-personal communications were scored using rubrics developed and tested by the team

Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice

<p>Abstract</p> <p>Background</p> <p>Prosaposin encodes, in tandem, four small acidic activator proteins (saposins) with specificities for glycosphingolipid (GSL) hydrolases in lysosomes. Extensive GSL storage occurs in various central nervous system regions in mammalian prosaposin deficiencies.</p> <p>Results</p> <p>Our hypomorphic prosaposin deficient mouse, PS-NA, exhibited 45% WT levels of brain saposins and showed neuropathology that included neuronal GSL storage and Purkinje cell loss. Impairment of neuronal function was observed as early as 6 wks as demonstrated by the narrow bridges tests. Temporal transcriptome microarray analyses of brain tissues were conducted with mRNA from three prosaposin deficient mouse models: PS-NA, prosaposin null (PS-/-) and a V394L/V394L glucocerebrosidase mutation combined with PS-NA (4L/PS-NA). Gene expression alterations in cerebrum and cerebellum were detectable at birth preceding the neuronal deficits. Differentially expressed genes encompassed a broad spectrum of cellular functions. The number of down-regulated genes was constant, but up-regulated gene numbers increased with age. CCAAT/enhancer-binding protein delta (CEBPD) was the only up-regulated transcription factor in these two brain regions of all three models. Network analyses revealed that CEBPD has functional relationships with genes in transcription, pro-inflammation, cell death, binding, myelin and transport.</p> <p>Conclusion</p> <p>These results show that: 1) Regionally specific gene expression abnormalities precede the brain histological and neuronal function changes, 2) Temporal gene expression profiles provide insights into the molecular mechanism during the GSL storage disease course, and 3) CEBPD is a candidate regulator of brain disease in prosaposin deficiency to participate in modulating disease acceleration or progression.</p

Real-world outcomes of sipuleucel-T treatment in PROCEED, a prospective registry of men with metastatic castration-resistant prostate cancer.

BackgroundThe large registry, PROVENGE Registry for the Observation, Collection, and Evaluation of Experience Data (PROCEED)(NCT01306890), evaluated sipuleucel-T immunotherapy for asymptomatic/minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC).MethodsPROCEED enrolled patients with mCRPC receiving 3 biweekly sipuleucel-T infusions. Assessments included overall survival (OS), serious adverse events (SAEs), cerebrovascular events (CVEs), and anticancer interventions (ACIs). Follow-up was for ≥3&nbsp;years or until death or study withdrawal.ResultsIn 2011-2017, 1976 patients were followed for 46.6&nbsp;months (median). The median age was 72&nbsp;years, and the baseline median prostate-specific antigen level was 15.0&nbsp;ng/mL; 86.7% were white, and 11.6% were African American. Among the patients, 1902 had 1 or more sipuleucel-T infusions. The median OS was 30.7&nbsp;months (95% confidence interval [CI], 28.6-32.2&nbsp;months). Known prognostic factors were independently associated with OS in a multivariable analysis. Among the 1255 patients who died, 964 (76.8%) died of prostate cancer (PC) progression. The median time from the first infusion to PC death was 42.7&nbsp;months (95% CI, 39.4-46.2&nbsp;months). The incidence of sipuleucel-T-related SAEs was 3.9%. The incidence of CVEs was 2.8%, and the rate per 100 person-years was 1.2 (95% CI, 0.9-1.6). The CVE incidence among 11,972 patients with mCRPC from the Surveillance, Epidemiology, and End Results-Medicare database was 2.8%; the rate per 100 person-years was 1.5 (95% CI, 1.4-1.7). One or more ACIs (abiraterone, enzalutamide, docetaxel, cabazitaxel, or radium 223) were received by 77.1% of the patients after sipuleucel-T; 32.5% and 17.4% of the patients experienced 1- and 2-year treatment-free intervals, respectively.ConclusionsPROCEED provides contemporary survival data for sipuleucel-T-treated men in a real-world setting of new life-prolonging agents, which will be useful in discussing treatment options with patients and in powering future trials with sipuleucel-T. The safety and tolerability of sipuleucel-T in PROCEED were consistent with previous findings