Logic Locking over TFHE for Securing User Data and Algorithms

2024 29th Asia and South Pacific Design Automation Conference (ASP-DAC), January 22-25, 2024, Incheon, Republic of KoreaThis paper proposes the application of logic locking over TFHE to protect both user data and algorithms, such as input user data and models in machine learning inference applications. With the proposed secure computation protocol algorithm evaluation can be performed distributively on honest-but-curious user computers while keeping the algorithm secure. To achieve this, we combine conventional logic locking for untrusted foundries with TFHE to enable secure computation. By encrypting the logic locking key using TFHE, the key is secured with the degree of TFHE. We implemented the proposed secure protocols for combinational logic neural networks and decision trees using LUT-based obfuscation. Regarding the security analysis, we subjected them to the SAT attack and evaluated their resistance based on the execution time. We successfully configured the proposed secure protocol to be resistant to the SAT attack in all machine learning benchmarks. Also, the experimental result shows that the proposed secure computation involved almost no TFHE runtime overhead in a test case with thousands of gates

The Combination of D-dimer and Glasgow Prognostic Score Can Be Useful in Predicting VTE in Patients with Stage IIIC and IVA Ovarian Cancer

Cancer patients have increased risk of venous thromboembolism (VTE) that must be assessed before treatment. This study aimed to determine effective VTE biomarkers in gynecologic cancer (GC). We investigated the correlation between D-dimer levels, Khorana risk score (KRS), Glasgow prognostic score (GPS), and VTE in 1499 GC patients (583 cervical cancer (CC), 621 endometrial cancer (EC), and 295 ovarian cancer (OC) patients) treated at our institution between January 2008 and December 2019. χ2 and Mann–Whitney U-tests were used to determine statistical significance. We used receiver operating characteristic-curve analysis to evaluate the discriminatory ability of each parameter. D-dimer levels were significantly correlated with KRS and GPS in patients with GC. VTE was diagnosed in 11 CC (1.9%), 27 EC (4.3%), and 39 OC patients (13.2%). Optimal D-dimer cut-off values for VTE were 3.1, 3.2, and 3.9 μg/ml in CC, EC and OC patients, respectively. D-dimer could significantly predict VTE in all GC patients. Furthermore, D-dimer combined with GPS was more accurate in predicting VTE than other VTE biomarkers in stage IIIC and IVA OC (AUC: 0.846; p<0.001). This study demonstrates that combined D-dimer and GPS are useful in predicting VTE in patients with OC

Not taking sick leave for gynecologic cancer treatment is negatively associated with returning to the same workplace

Background: Gynecologic cancers are one of the most common types of malignancies in working-age women. We aimed to determine the factors that impede women from returning to the same workplace after treatment for such cancers. Methods: A questionnaire-based survey was conducted on 194 women who underwent treatment for gynecologic cancer at the Okayama University (≥1 year after cancer treatment and Results: The median age at diagnosis was 49.0 years, and the median time from cancer treatment to questionnaire completion was 3.8 years. Not returning to the same workplace was positively associated with not being regularly employed (P = 0.018), short work time per day (P = 0.023), low personal income (P = 0.004), not taking sick leave (P Conclusions: Not taking sick leave likely was negatively associated with returning to the same workplace after the treatment for gynecologic cancer. Therefore, we suggest that steps be taken to formally introduce a sick leave system over and above the paid leave system in Japan

Large Population of ALMA Galaxies at z>6 with Very High [OIII]88um to [CII]158um Flux Ratios: Evidence of Extremely High Ionization Parameter or PDR Deficit?

We present our new ALMA observations targeting [OIII]88um, [CII]158um, [NII]122um, and dust continuum emission for three Lyman break galaxies at z=6.0293-6.2037 identified in the Subaru/Hyper Suprime-Cam survey. We clearly detect [OIII] and [CII] lines from all of the galaxies at 4.3-11.8sigma levels, and identify multi-band dust continuum emission in two of the three galaxies, allowing us to estimate infrared luminosities and dust temperatures simultaneously. In conjunction with previous ALMA observations for six galaxies at z>6, we confirm that all the nine z=6-9 galaxies have high [OIII]/[CII] ratios of L[OIII]/L[CII]~3-20, ~10 times higher than z~0 galaxies. We also find a positive correlation between the [OIII]/[CII] ratio and the Lya equivalent width (EW) at the ~90% confidence level. We carefully investigate physical origins of the high [OIII]/[CII] ratios at z=6-9 using Cloudy, and find that high density of the interstellar medium, low C/O abundance ratio, and the cosmic microwave background attenuation are responsible to only a part of the z=6-9 galaxies. Instead, the observed high [OIII]/[CII] ratios are explained by 10-100 times higher ionization parameters or low photodissociation region (PDR) covering fractions of 0-10%, both of which are consistent with our [NII] observations. The latter scenario can be reproduced with a density bounded nebula with PDR deficit, which would enhance the Lya, Lyman continuum, and C+ ionizing photons escape from galaxies, consistent with the [OIII]/[CII]-Lya EW correlation we find.Comment: 20 pages, 18 figures, Accepted for publication in Ap

Subaru High-z Exploration of Low-Luminosity Quasars (SHELLQs) VIII. A less biased view of the early co-evolution of black holes and host galaxies

We present ALMA [CII] line and far-infrared (FIR) continuum observations of three $z > 6$ low-luminosity quasars ($M_{\rm 1450} > -25$) discovered by our Subaru Hyper Suprime-Cam (HSC) survey. The [CII] line was detected in all three targets with luminosities of $(2.4 - 9.5) \times 10^8~L_\odot$, about one order of magnitude smaller than optically luminous ($M_{\rm 1450} \lesssim -25$) quasars. The FIR continuum luminosities range from $< 9 \times 10^{10}~L_\odot$ (3$\sigma$ limit) to $\sim 2 \times 10^{12}~L_\odot$, indicating a wide range in star formation rates in these galaxies. Most of the HSC quasars studied thus far show [CII]/FIR luminosity ratios similar to local star-forming galaxies. Using the [CII]-based dynamical mass ($M_{\rm dyn}$) as a surrogate for bulge stellar mass ($M_{\rm bulge}$), we find that a significant fraction of low-luminosity quasars are located on or even below the local $M_{\rm BH} - M_{\rm bulge}$ relation, particularly at the massive end of the galaxy mass distribution. In contrast, previous studies of optically luminous quasars have found that black holes are overmassive relative to the local relation. Given the low luminosities of our targets, we are exploring the nature of the early co-evolution of supermassive black holes and their hosts in a less biased way. Almost all of the quasars presented in this work are growing their black hole mass at much higher pace at $z \sim 6$ than the parallel growth model, in which supermassive black holes and their hosts grow simultaneously to match the local $M_{\rm BH} - M_{\rm bulge}$ relation at all redshifts. As the low-luminosity quasars appear to realize the local co-evolutionary relation even at $z \sim 6$, they should have experienced vigorous starbursts prior to the currently observed quasar phase to catch up with the relation.Comment: 19 pages, 11 figures, 4 tables. Accepted for publication in Publications of the Astronomical Society of Japan (PASJ

Subaru High-z Exploration of Low-Luminosity Quasars (SHELLQs) III. Star formation properties of the host galaxies at z≳6z \gtrsim 6 studied with ALMA

We present our ALMA Cycle 4 measurements of the [CII] emission line and the underlying far-infrared (FIR) continuum emission from four optically low-luminosity ($M_{\rm 1450} > -25$) quasars at $z \gtrsim 6$ discovered by the Subaru Hyper Suprime Cam (HSC) survey. The [CII] line and FIR continuum luminosities lie in the ranges $L_{\rm [CII]} = (3.8-10.2) \times 10^8~L_\odot$ and $L_{\rm FIR} = (1.2-2.0) \times 10^{11}~L_\odot$, which are at least one order of magnitude smaller than those of optically-luminous quasars at $z \gtrsim 6$. We estimate the star formation rates (SFR) of our targets as $\simeq 23-40~M_\odot ~{\rm yr}^{-1}$. Their line and continuum-emitting regions are marginally resolved, and found to be comparable in size to those of optically luminous quasars, indicating that their SFR or likely gas mass surface densities (key controlling parameter of mass accretion) are accordingly different. The $L_{\rm [CII]}/L_{\rm FIR}$ ratios of the hosts, $\simeq (2.2-8.7) \times 10^{-3}$, are fully consistent with local star-forming galaxies. Using the [CII] dynamics, we derived their dynamical masses within a radius of 1.5-2.5 kpc as $\simeq (1.4-8.2) \times 10^{10}~M_\odot$. By interpreting these masses as stellar ones, we suggest that these faint quasar hosts are on or even below the star-forming main sequence at $z \sim 6$, i.e., they appear to be transforming into quiescent galaxies. This is in contrast to the optically luminous quasars at those redshifts, which show starburst-like properties. Finally, we find that the ratios of black hole mass to host galaxy dynamical mass of the most of low-luminosity quasars including the HSC ones are consistent with the local value. The mass ratios of the HSC quasars can be reproduced by a semi-analytical model that assumes merger-induced black hole-host galaxy evolution.Comment: 20 pages, 9 figures, 4 tables. Accepted for publication in PAS

Efficacy and safety of olaparib, olaparib plus bevacizumab and niraparib maintenance treatment in Japanese patients with platinum-sensitive advanced ovarian cancer

Objective: To investigate whether maintenance treatment could be safely and effectively performed with olaparib, olaparib plus bevacizumab and niraparib in platinum-sensitive advanced ovarian cancer at multiple institutions in Japan. Methods: We investigated progression-free survival and adverse events in 117 patients with platinum-sensitive advanced ovarian cancer treated with maintenance therapy. Results: The median progression-free survival of 117 patients was 20.1 months. Patients with germline BRCA pathogenic variants had a significantly better prognosis than the other groups (P Conclusion: Maintenance treatment was performed effectively and safely. Renal function deterioration is likely to occur during maintenance treatment, and careful administration is important in platinum-sensitive advanced ovarian cancer

Wide and Deep Exploration of Radio Galaxies with Subaru HSC (WERGS). III. Discovery of a z = 4.72 Radio Galaxy with Lyman Break Technique

We report a discovery of $z = 4.72$ radio galaxy, HSC J083913.17+011308.1, by using the Lyman break technique with the Hyper Suprime-Cam Subaru Strategic Survey (HSC-SSP) catalog for VLA FIRST radio sources. The number of known high-$z$ radio galaxies (HzRGs) at $z > 3$ is quite small to constrain the evolution of HzRGs so far. The deep and wide-area optical survey by HSC-SSP enables us to apply the Lyman break technique to a large search for HzRGs. For an HzRG candidate among pre-selected $r$-band dropouts with a radio detection, a follow-up optical spectroscopy with GMOS/Gemini has been performed. The obtained spectrum presents a clear Ly$\alpha$ emission line redshifted to $z=4.72$. The SED fitting analysis with the rest-frame UV and optical photometries suggests the massive nature of this HzRG with $\log{M_*/M_{\odot}} = 11.4$. The small equivalent width of Ly$\alpha$ and the moderately red UV colors indicate its dusty host galaxy, implying a chemically evolved and dusty system. The radio spectral index does not meet a criterion for an ultra-steep spectrum: $\alpha^{325}_{1400}$ of $-1.1$ and $\alpha^{150}_{1400}$ of $-0.9$, demonstrating that the HSC-SSP survey compensates for a sub-population of HzRGs which are missed in surveys focusing on an ultra-steep spectral index.Comment: 10 pages, 5 figures, accepted for publication in A

Discovery of the First Low-Luminosity Quasar at z > 7

We report the discovery of a quasar at z = 7.07, which was selected from the deep multi-band imaging data collected by the Hyper Suprime-Cam (HSC) Subaru Strategic Program survey. This quasar, HSC J124353.93+010038.5, has an order of magnitude lower luminosity than do the other known quasars at z > 7. The rest-frame ultraviolet absolute magnitude is M1450 = -24.13 +/- 0.08 mag and the bolometric luminosity is Lbol = (1.4 +/- 0.1) x 10^{46} erg/s. Its spectrum in the optical to near-infrared shows strong emission lines, and shows evidence for a fast gas outflow, as the C IV line is blueshifted and there is indication of broad absorption lines. The Mg II-based black hole mass is Mbh = (3.3 +/- 2.0) x 10^8 Msun, thus indicating a moderate mass accretion rate with an Eddington ratio 0.34 +/- 0.20. It is the first z > 7 quasar with sub-Eddington accretion, besides being the third most distant quasar, known to date. The luminosity and black hole mass are comparable to, or even lower than, those measured for the majority of low-z quasars discovered by the Sloan Digital Sky Survey, and thus this quasar likely represents a z > 7 counterpart to quasars commonly observed in the low-z universe.Comment: Accepted for publication in ApJ Letter

Subaru High-z Exploration of Low-luminosity Quasars (SHELLQs). XIII. Large-scale Feedback and Star Formation in a Low-luminosity Quasar at z = 7.07 on the Local Black Hole to Host Mass Relation

We present Atacama Large Millimeter/submillimeter Array [C II] 158 μm line and underlying far-infrared (FIR) continuum emission observations (0 70 × 0 56 resolution) toward HSC J124353.93+010038.5 (J1243+0100) at z = 7.07, the only low-luminosity (M1450 > −25 mag) quasar currently known at z > 7. The FIR continuum is bright (1.52 mJy) and resolved with a total luminosity of LFIR = 3.5 × 1012 Le. The spatially extended component is responsible for ∼40% of the emission. The area-integrated [C II] spectrum shows a broad wing (FWHM = 997 km s−1 , L[C II] = 1.2 × 109 Le), as well as a bright core (FWHM = 235 km s−1 , L[C II] = 1.9 × 109 Le). This wing is the first detection of a galactic-scale quasar-driven outflow (atomic outflow rate >447 Me yr−1 ) at z > 7. The estimated large mass-loading factor of the total outflow (e.g., 9 relative to the [C II]-based star formation rate) suggests that this outflow will soon quench the star formation of the host. The core gas dynamics are governed by rotation, with a rotation curve suggestive of a compact bulge (∼3.3 × 1010 Me), although it is not yet spatially resolved. Finally, we found that J1243+0100 has a black hole mass–to–dynamical mass (and –to–bulge mass) ratio of ∼0.4% (∼1%), consistent with the local value within the uncertainties. Our results therefore suggest that the black hole–host coevolution relation is already in place at z ∼ 7 for this object