Coping strategies and health-related quality of life in children and adolescents with type 1 diabetes

The aim of this study was to identify relationships between coping strategies and different aspects of health-related quality of life in children with type 1 diabetes measured with the Croatian translation of the PedsQL 4.0 Generic Core Scales and PedsQL Diabetes Module. The sample consisted of 199 schoolchildren: 47 patients with type 1 diabetes and 152 healthy children. Children health problems were rated with PedsQL 4.0 Generic Core Scale and with PedsQL Diabetes Module. Coping strategies were measured with The Coping Strategies Inventory for Children and Adolescents. The results showed that all subscales of the PedsQL 4.0 Generic Core Scales and the PedsQL Diabetes Module have satisfactory reliability with the majority of scales exceeding a Cronbach α of 0,70. Significant correlations were found between coping strategies and different aspects of health-related quality of life and those correlations were higher in girls than in boys. The findings of the present study suggest that child psychologists and clinicians treating children and adolescents suffering diabetes should address coping strategies related to specific health-related problems and assist them in developing more effective ways of coping

The Elbow-EpiTrainer : A method of delivering graded resistance to the extensor carpi radialis brevis. Effectiveness of a prototype device in a healthy population

This document is the Accepted Manuscript version of the following article: Navsaria R, Ryder DM, Lewis JS, et al, 'The Elbow-EpiTrainer: a method of delivering graded resistance to the extensor carpi radialis brevi:. Effectiveness of a prototype device in a healthy population', British Journal of Sports Medicine, Vol. 49(5):318-322, March 2015, available online at: http://bjsm.bmj.com/content/49/5/318. Published by the BMJ Publishing Group Limited.Background: Tennis elbow or lateral epicondylopathy (LE) is experienced as the lateral elbow has a reported prevalence of 1.3%, with symptoms lasting up to 18 months. LE is most commonly attributed to tendinopathy involving the extensor carpi radialis brevis (ECRB) tendon. The aim of tendinopathy management is to alleviate symptoms and restore function that initially involves relative rest followed by progressive therapeutic exercise. Objective: To assess the effectiveness of two prototype exercises using commonly available clinical equipment to progressively increase resistance and activity of the ECRB. Method: Eighteen healthy participants undertook two exercise progressions. Surface electromyography was used to record ECRB activity during the two progressions, involving eccentric exercises of the wrist extensors and elbow pronation exercises using a prototype device. The two progressions were assessed for their linearity of progression using repeated ANOVA and linear regression analysis. Five participants repeated the study to assess reliability. Results: The exercise progressions led to an increase in ECRB electromyographic (EMG) activity (p0.7) between the first and second tests for five participants. Conclusions: Manipulation of resistance and leverage with the prototype exercises was effective in creating significant increases of ECRB normalised EMG activity in a linear manner that may, with future research, become useful to clinicians treating LE. In addition, between trial reliability for the device to generate a consistent load was acceptable.Peer reviewe

The Tic20 gene family: Phylogenetic analysis and evolutionary considerations

Tic20 is a polytopic protein of the inner envelope membrane of chloroplasts, and it is proposed to act as a translocation channel during chloroplast protein import. By analysing 29 sequences from diverse organisms, it was evident that Tic20-related proteins form two distinct clades, termed Group 1 and Group 2. The former group includes canonical Tic20 proteins that are essential for chloroplast development, while members of the latter are of unknown function. An increased evolutionary rate, in connection with adaptation to terrestrial life, was detected in Group 1. Interestingly, the sub-cellular (genomic) localization of genes coding for Group 1 proteins differs between evolutionary lineages

Toc75_trees_Topel_PSB_2011

The resulting 50% majority rule consensus trees (with and without branch length data) from the analysis of the data in "Toc75_allignment_Topel_PSB_2011.nex". The tree with branch lengths was used for figure 1 in the paper

Toc75_allignment_Topel_PSB_2011

Alignment of the C-terminal end of 48 Toc75 amino acid sequences. The alignemnt has been truncated so that only the part corresponding to residues 651-818 of atToc75-III remains and was used for the phylogenetic analysis. Also included in the file are the instructions to MrBayes, that was used to analyze the data

trnLF-trnSG.tree.fig4

The resulting 50% majority rule consensus trees (with and without branch length data) from the analysis of the data in "trnLF-trnSG.alignemnt.fig4.nex". The tree with branch lengths was used for figure 4

ITS.ETS.alignment.fig_3

Alignment of 1075 DNA characters and 136 gap-code characters from the nuclear ribosomal markers 'ITS1 (partial), 5.8S rRNA gene and ITS2 (partial)' and 'external transcribed spacer (partial) and 18S rRNA gene (partial)'. Gaps are indicated by "-". Also included in the file are the instructions to MrBayes used to analyze the data

Geographical distribution of the ivesioids.

<p>Shaded area represents the exten of the Great Basin. Locations where climate data were sampled for the bioclimatic models for extant species are marked with dots. State names are abbreviated: AZ – Arizona, CA – California, CO – Colorado, ID – Idaho, MT – Montana, NE – Nevada, NM – New Mexico, OR – Oregon, UT – Utah, WA – Washington and WY – Wyoming. Background image by <a href="http://www.earthobservatory.nasa.gov" target="_blank">www.earthobservatory.nasa.gov</a>.</p

Ancestral bioclimatic models projected into palaeoclimatic scenarios.

<p>Red areas are inferred to have had a suitable climate for the ancestral population by four climate variables and areas in yellow by three. Numbers corresponds to the nodes in the ivesioid clade in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050358#pone-0050358-g003" target="_blank">figure 3</a>.</p

Optimized ancestral maximum and minimum values for the four climate variables used. Temperatures are given in °C and precipitation in millimeters.

<p>Node numbers corresponds to the numbers indicated in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050358#pone.0050358.s002" target="_blank">figure S2</a>.</p