12,923 research outputs found
Rotating 5D-Kaluza-Klein Space-Times from Invariant Transformations
Using invariant transformations of the five-dimensional Kaluza-Klein (KK)
field equations, we find a series of formulae to derive axial symmetric
stationary exact solutions of the KK theory starting from static ones. The
procedure presented in this work allows to derive new exact solutions up to
very simple integrations. Among other results, we find exact rotating solutions
containing magnetic monopoles, dipoles, quadripoles, etc., coupled to scalar
and to gravitational multipole fields.Comment: 24 pages, latex, no figures. To appear in Gen. Rel. Grav., 32,
(2000), in pres
Oscillatons revisited
In this paper, we study some interesting properties of a spherically
symmetric oscillating soliton star made of a real time-dependent scalar field
which is called an oscillaton. The known final configuration of an oscillaton
consists of a stationary stage in which the scalar field and the metric
coefficients oscillate in time if the scalar potential is quadratic. The
differential equations that arise in the simplest approximation, that of
coherent scalar oscillations, are presented for a quadratic scalar potential.
This allows us to take a closer look at the interesting properties of these
oscillating objects. The leading terms of the solutions considering a quartic
and a cosh scalar potentials are worked in the so called stationary limit
procedure. This procedure reveals the form in which oscillatons and boson stars
may be related and useful information about oscillatons is obtained from the
known results of boson stars. Oscillatons could compete with boson stars as
interesting astrophysical objects, since they would be predicted by scalar
field dark matter models.Comment: 10 pages REVTeX, 10 eps figures. Updated files to match version
published in Classical and Quantum Gravit
Plasma membrane-specific interactome analysis reveals calpain 1 as a druggable modulator of rescued Phe508del-CFTR cell surface stability
Cystic fibrosis (CF) is a genetic disease caused by mutations in the gene encoding CF transmembrane conductance regulator (CFTR), a chloride channel normally expressed at the surface of epithelial cells. The most frequent mutation, resulting in Phe-508 deletion, causes CFTR misfolding and its premature degradation. Low temperature or pharmacological correctors can partly rescue the Phe508del-CFTR processing defect and enhance trafficking of this channel variant to the plasma membrane (PM). Nevertheless, the rescued channels have an increased endocytosis rate, being quickly removed from the PM by the peripheral protein quality-control pathway. We previously reported that rescued Phe508del-CFTR (rPhe508del) can be retained at the cell surface by stimulating signaling pathways that coax the adaptor molecule ezrin (EZR) to tether rPhe508del–Na+/H+-exchange regulatory factor-1 (NHERF1) complexes to the actin cytoskeleton, thereby averting the rapid internalization of this channel variant. However, the molecular basis for why rPhe508del fails to recruit active EZR to the PM remains elusive. Here, using a proteomics approach, we characterized and compared the core components of wt-CFTR– or rPhe508del–containing macromolecular complexes at the surface of human bronchial epithelial cells. We identified calpain 1 (CAPN1) as an exclusive rPhe508del interactor that prevents active EZR recruitment, impairs rPhe508del anchoring to actin, and reduces its stability in the PM. We show that either CAPN1 downregulation or its chemical inhibition dramatically improves the functional rescue of Phe508del-CFTR in airway cells. These observations suggest that CAPN1 constitutes an attractive target for pharmacological intervention, as part of CF combination therapies restoring Phe508del-CFTR function.This work was supported by a center grant UID/MULTI/04046/2019
to BioISI and project PTDC/BIA-CEL/28408/2017 and IF2012 to PM,
both from FCT, Portugal. AMM was recipient of fellowship
SFRH/BD/52490/2014 from BioSYS PhD programme PD65-2012,
and PB of fellowship SFRH/BPD/94322/2013.N/
Unified Models of Inflation and Quintessence
We apply an extended version of the method developed in reference
Int.J.Mod.Phys.D5(1996)71, to derive exact cosmological (flat)
Friedmann-Robertson-Walker solutions in RS2 brane models with a perfect fluid
of ordinary matter plus a scalar field fluid trapped on the brane. We found new
exact solutions, that can serve to unify inflation and quintessence in a common
theoretical framework.Comment: 8 pages, no figure
Decoherence, pointer engineering and quantum state protection
We present a proposal for protecting states against decoherence, based on the
engineering of pointer states. We apply this procedure to the vibrational
motion of a trapped ion, and show how to protect qubits, squeezed states,
approximate phase eigenstates and superpositions of coherent states.Comment: 1 figur
Axisymmetric Stationary Solutions as Harmonic Maps
We present a method for generating exact solutions of Einstein equations in
vacuum using harmonic maps, when the spacetime possesses two commutating
Killing vectors. This method consists in writing the axisymmetric stationry
Einstein equations in vacuum as a harmonic map which belongs to the group
SL(2,R), and decomposing it in its harmonic "submaps". This method provides a
natural classification of the solutions in classes (Weil's class, Lewis' class
etc).Comment: 17 TeX pages, one table,( CINVESTAV- preprint 12/93
Entangled coherent states and squeezing in N trapped ions
We consider a resonant bichromatic excitation of N trapped ions that
generates displacement and squeezing in their collective motion conditioned to
their ionic internal state, producing eventually Scrhodinger cat states and
entangled squeezing. Furthermore, we study the case of tetrachromatic
illumination or producing the so called entangled coherent states in two
motional normal modes.Comment: 4 Revtex pages, no figures. To appear in Proceedings of "Mysteries,
Puzzles and Paradoxes in Quantum Mechanics", Garda Lake, Italy (2001
Identification of a spatio-temporal model of crystal growth based on boundary curvature
A new method of identifying the spatio-temporal transition rule of crystal growth is introduced based on the connection between growth kinetics and dentritic
morphology. Using a modified three-point-method, curvatures of the considered crystal branch are calculated and curvature direction is used to measure growth
velocity. A polynomial model is then produced based on a curvature-velocity relationship to represent the spatio-temporal growth process. A very simple simulation
example is used initially to clearly explain the methodology. The results of identifying a model from a real crystal growth experiment show that the proposed
method can produce a good representation of crystal growth
Inflation from IIB Superstrings with Fluxes
We study the conditions needed to have an early epoch of inflationary
expansion with a potential coming from IIB superstring theory with fluxes
involving two moduli fields. The phenomenology of this potential is different
from the usual hybrid inflation scenario and we analize the possibility that
the system of field equations undergo a period of inflation in three different
regimes with the dynamics modified by a Randall-Sundrum II term in the
Friedmann equation. We find that the system can produce inflation and due to
the modification of the dynamics, a period of accelerated contraction can
follow or preceed this inflationary stage depending on the sign of one of the
parameters of the potential. We discuss on the viability of this model in a
cosmological context.Comment: 10 pages, 6 figure
- …