Slavko Zlatić's vocal music

Slavko Zlatić je skladatelj koji je svojim radom ostavio dubok trag ne samo u istarskoj, već i u hrvatskoj umjetničkoj glazbi. Zadužio je buduće naraštaje svojim radovima i angažmanom na polju amaterizma. Zaslužan je i za stvaranje studija glazbe na današnjem Sveučilištu Jurja Dobrile u Puli kojemu je upravo on udario temelj svojim predanim radom i angažmanom. Isto tako, vrlo je važna društvena djelatnost kojom se bavio pa je iza sebe ostavio veliki broj zapaženih nastupa. Danas se susret zborova „Naš kanat je lip“, koji se svake godine održava u Poreču, održava njemu u čast u vrijeme njegova rođendana. Ostavio je značajan opus umjetničkih djela, kako vokalnih, tako instrumentalnih i vokalno-instrumentalnih. Nije se libio koristiti elemente narodnog folklora u instrumentalnoj umjetničkoj glazbi na način da je koristio instrumente nazalnog tona u svrhu dočaravanja sviranja na narodnim instrumentima. Upravo je na tom polju potpuni inovator. Isto tako, nije mu bilo strano niti koristiti suvremene skladateljske tehnike vidljive u brojnim djelima. U velikom dijelu svojih vokalnih skladbi koristio se narodnim napjevima koje je sam prikupljao i zapisivao, no i sam je skladao melodije po uzoru na narodne. Koristio se pritom već poznatim načinima zapisivanja i harmoniziranja narodnih napjeva do kojih su svojim proučavanjem i radom došla dvojica njegovih prethodnika - Ivan Matetić Ronjgov i Matko Brajša Rašan. U skladbama na području vokalne glazbe u kojima se javljaju elementi istarskoprimorskog folklora, melodija koja se koristi uglavnom se sastoji od izmjene malih i velikih sekundi te malih terca, u obratu seksta sa završetkom u oktavi (unisonu). Kad je riječ o melodijama preuzetim iz narodnog dvoglasja, Zlatić većinom podvostručava dvije postojeće melodijske linije. U vlastitim melodijama je nešto slobodniji, no nastoji skladati u duhu narodne glazbe. Harmonijski jezik kojim se koristi na navedenom polju odudara od klasične harmonije zbog svojih specifičnosti koje nije moguće na standardni način uklopiti u njezine zakonitosti. Vidljivo je to u skladbama koje su nastale na temelju narodnih napjeva koje nije moguće klasično harmonizirati iz razloga što napjevi u sebi sadrže tonove koji ne odgovaraju poznatim ljestvicama već su proizašli iz istarskog niza. Skladbe koje Zlatić sklada na tekst narodne poezije nastaju po uzoru na narodne skladbe te u njima koristi tonske nizove po istom uzoru pa je i harmonizacija u istom duhu. Skladbe nastale u duhu suvremenog načina skladanja prikazuju Zlatića u potpuno drugom svjetlu. Nije mu strana upotreba modalnosti (Varijacije na narodnu temu) kao ni skladanje u duhu impresionizma (Čačkole). Iznimno je interesantna skladba Il brindisi u kojoj Zlatić prikazuje glazbu prisutnu u gradskim sredinama istarskog primorja sjedinjenu s elementima istarskog folklora. Širina Zlatićeva skladateljskog opusa u smislu upotrebe različitih stilova i stvaranja pod utjecajem narodne glazbe je vrlo interesantna. Zlatić u svojim djelima na području vokalne glazbe uspijeva postići zavidnu širinu. Rezultat njegova rada su dijela velike ljepote i umjetničke vrijednosti koja se učestalo izvode na brojnim pozornicama.Slavko Zlatić is a composer whose work is very significant not only for the istrian music, but for the croatian music also. He left a big influence on the younger population of musicians with his compositions and works on the field of music amateurism. We can consider him as the founder of the music study that has today become the Music academy of the University of Juraj Dobrila in Pula. What it also very important is his work on the social field where he made numerous concerts. The annual choir meeting „Naš kanat je lip“ takes place in occasion of his birthday in Poreč every year. Zlatić left a significant amount of works in the field of vocal, instrumental and vocalinstrumental music. In his instrumental works he didn’t hesitate to use folk elements by using instruments with nasal tone to imitate the way of playing on the folk instruments. That’s the field where he was an absolute innovator. Besides that, the composition technique he worked with was very modern. In many of his vocal works he used folk melodies that he collected. What is interesting is that he composed his own melodies in the folk manner as well. In doing so he used the knowledge achieved by his antecedents Ivan Matetic Ronjgov and Matko Brajsa Rasan’s in the field of transcribing folk melodies. In the vocal compositions where he made use of istrian folk elements, the melody is made of exchanging small intervals, minor and major seconds and thirds, and sixths with octave ending (unison). In the melodies made of folk two voice music, Zlatić uses the technique of doubling the two already existing melodic lines. In his own compositions he is a little more free in composing but also tries to compose in the manner of folk music. His harmonic language in that field is a bit different from the classical harmonic language because of the specifics that aren’t possible to put in the standard harmonic rules. The compositions born in the folk manner aren’t suitable to harmonize in the classical way because the folk melodies are made of sounds that aren’t found in the standard major or minor keys, rather, they are the product of the so called “Istrian key”. The compositions made on the basis of the folk poetry are made of the same characteristics as earlier explained. The compositions composed in the contemporary way show Zlatić in a whole new light. The use of modality (Varijacije na narodnu temu) as well as composing in the impressionistic manner (Čačkole) aren’t new to him. The piece Il brindisi is very interesting because in that work Zlatić shows the music as it was in the istrian cities of the past with some element of istrian folklore. In the field of composing vocal music Zlatić’s conception is very large. The product of his work are compositions of significant beauty and value. His works are very popular and played very often across the country and beyond

Slavko Zlatić's vocal music

Slavko Zlatić je skladatelj koji je svojim radom ostavio dubok trag ne samo u istarskoj, već i u hrvatskoj umjetničkoj glazbi. Zadužio je buduće naraštaje svojim radovima i angažmanom na polju amaterizma. Zaslužan je i za stvaranje studija glazbe na današnjem Sveučilištu Jurja Dobrile u Puli kojemu je upravo on udario temelj svojim predanim radom i angažmanom. Isto tako, vrlo je važna društvena djelatnost kojom se bavio pa je iza sebe ostavio veliki broj zapaženih nastupa. Danas se susret zborova „Naš kanat je lip“, koji se svake godine održava u Poreču, održava njemu u čast u vrijeme njegova rođendana. Ostavio je značajan opus umjetničkih djela, kako vokalnih, tako instrumentalnih i vokalno-instrumentalnih. Nije se libio koristiti elemente narodnog folklora u instrumentalnoj umjetničkoj glazbi na način da je koristio instrumente nazalnog tona u svrhu dočaravanja sviranja na narodnim instrumentima. Upravo je na tom polju potpuni inovator. Isto tako, nije mu bilo strano niti koristiti suvremene skladateljske tehnike vidljive u brojnim djelima. U velikom dijelu svojih vokalnih skladbi koristio se narodnim napjevima koje je sam prikupljao i zapisivao, no i sam je skladao melodije po uzoru na narodne. Koristio se pritom već poznatim načinima zapisivanja i harmoniziranja narodnih napjeva do kojih su svojim proučavanjem i radom došla dvojica njegovih prethodnika - Ivan Matetić Ronjgov i Matko Brajša Rašan. U skladbama na području vokalne glazbe u kojima se javljaju elementi istarskoprimorskog folklora, melodija koja se koristi uglavnom se sastoji od izmjene malih i velikih sekundi te malih terca, u obratu seksta sa završetkom u oktavi (unisonu). Kad je riječ o melodijama preuzetim iz narodnog dvoglasja, Zlatić većinom podvostručava dvije postojeće melodijske linije. U vlastitim melodijama je nešto slobodniji, no nastoji skladati u duhu narodne glazbe. Harmonijski jezik kojim se koristi na navedenom polju odudara od klasične harmonije zbog svojih specifičnosti koje nije moguće na standardni način uklopiti u njezine zakonitosti. Vidljivo je to u skladbama koje su nastale na temelju narodnih napjeva koje nije moguće klasično harmonizirati iz razloga što napjevi u sebi sadrže tonove koji ne odgovaraju poznatim ljestvicama već su proizašli iz istarskog niza. Skladbe koje Zlatić sklada na tekst narodne poezije nastaju po uzoru na narodne skladbe te u njima koristi tonske nizove po istom uzoru pa je i harmonizacija u istom duhu. Skladbe nastale u duhu suvremenog načina skladanja prikazuju Zlatića u potpuno drugom svjetlu. Nije mu strana upotreba modalnosti (Varijacije na narodnu temu) kao ni skladanje u duhu impresionizma (Čačkole). Iznimno je interesantna skladba Il brindisi u kojoj Zlatić prikazuje glazbu prisutnu u gradskim sredinama istarskog primorja sjedinjenu s elementima istarskog folklora. Širina Zlatićeva skladateljskog opusa u smislu upotrebe različitih stilova i stvaranja pod utjecajem narodne glazbe je vrlo interesantna. Zlatić u svojim djelima na području vokalne glazbe uspijeva postići zavidnu širinu. Rezultat njegova rada su dijela velike ljepote i umjetničke vrijednosti koja se učestalo izvode na brojnim pozornicama.Slavko Zlatić is a composer whose work is very significant not only for the istrian music, but for the croatian music also. He left a big influence on the younger population of musicians with his compositions and works on the field of music amateurism. We can consider him as the founder of the music study that has today become the Music academy of the University of Juraj Dobrila in Pula. What it also very important is his work on the social field where he made numerous concerts. The annual choir meeting „Naš kanat je lip“ takes place in occasion of his birthday in Poreč every year. Zlatić left a significant amount of works in the field of vocal, instrumental and vocalinstrumental music. In his instrumental works he didn’t hesitate to use folk elements by using instruments with nasal tone to imitate the way of playing on the folk instruments. That’s the field where he was an absolute innovator. Besides that, the composition technique he worked with was very modern. In many of his vocal works he used folk melodies that he collected. What is interesting is that he composed his own melodies in the folk manner as well. In doing so he used the knowledge achieved by his antecedents Ivan Matetic Ronjgov and Matko Brajsa Rasan’s in the field of transcribing folk melodies. In the vocal compositions where he made use of istrian folk elements, the melody is made of exchanging small intervals, minor and major seconds and thirds, and sixths with octave ending (unison). In the melodies made of folk two voice music, Zlatić uses the technique of doubling the two already existing melodic lines. In his own compositions he is a little more free in composing but also tries to compose in the manner of folk music. His harmonic language in that field is a bit different from the classical harmonic language because of the specifics that aren’t possible to put in the standard harmonic rules. The compositions born in the folk manner aren’t suitable to harmonize in the classical way because the folk melodies are made of sounds that aren’t found in the standard major or minor keys, rather, they are the product of the so called “Istrian key”. The compositions made on the basis of the folk poetry are made of the same characteristics as earlier explained. The compositions composed in the contemporary way show Zlatić in a whole new light. The use of modality (Varijacije na narodnu temu) as well as composing in the impressionistic manner (Čačkole) aren’t new to him. The piece Il brindisi is very interesting because in that work Zlatić shows the music as it was in the istrian cities of the past with some element of istrian folklore. In the field of composing vocal music Zlatić’s conception is very large. The product of his work are compositions of significant beauty and value. His works are very popular and played very often across the country and beyond

Mogu li faktori rizika biti bolji prediktori rane akutne mezenterijalne ishemije od laboratorijskih i slikovnih pretraga? Retrospektivna studija i algoritam za ranu intervenciju

Objectives The aim is to delineate relevant risk factors and construct an algorithm for earlier performance of selective mesenteric angiography, thus lowering mortality rates of acute mesenteric ischemia. Methods During a 5-year period 31 patients were examined. Thirteen risk factors were analysed and compared to standard diagnostic procedures. Results Only one patient did not have arterial hypertension. The second most common risk factor is atrial fibrillation with the incidence rate of 64.5%. The largest group of patients (38.7%) had two risk factors and there were 6.5% patients with six risk factors and 87.2% of all patients had two or more risk factors. In 67.7% of the patients we only performed emergency laparotomy due to inoperable state. Hospital mortality was 74.2%. Conclusions Combination of age over 70, hypertension and two or more risk factors associated with elevated D-dimers, in a patient with severe abdominal pain and minimal clinical findings with nonspecific laboratory findings and plain abdominal radiographs, could be an indication for early selective mesenteric angiography.Ciljevi Cilj je naznačiti relevantne faktore rizika i izraditi algoritam za ranije slučajeve selektivne mezenterijalne angiografije te na taj način smanjiti stopu smrtnosti akutne mezenterijalne ishemije. Metode Tijekom petogodišnjeg razdoblja pregledan je 31 pacijent. Analizirano je 13 faktora rizika koji su uspoređeni sa standardnim dijagnostičkim postupcima. Rezultati Samo jedan pacijent nije imao arterijsku hipertenziju. Drugi najčešći faktor rizika je atrijalna fibrilacija s učestalošću od 64,5%. Najveća skupina pacijenata (38,7%) imala je dva faktora rizika, 6,5% pacijenata imalo je šest faktora rizika, a 87,2% svih pacijenata imalo je dva ili više faktora rizika. U 67,7% pacijenata izveli smo samo hitnu laparotomiju zbog neoperabilnog stanja. Bolnička smrtnost bila je 74,2%. Zaključci Kombinacija dobi iznad 70, hipertenzije i dva ili više faktora rizika povezanih s povišenim D-dimerima, kod pacijenta sa znatnom abdominalnom boli i minimalnim kliničkim zaključcima s nespecifičnim laboratorijskim zaključcima i uobičajenim abdominalnim radiografima mogu biti indikacija za ranu selektivnu mezenterijalnu angiografiju

Tumor retroperitoneuma: pričaj mi o živcima Retroperitonealni femoralni schwannom sa jatrogenom postoperacijskom femoralnom neuropatijom: prikaz slučaja

Retroperitoneal femoral schwannomas constitute a rather small percentage of primary retroperitoneal tumors. Proper preoperative diagnosis is often difficult since imaging studies are nonspecific and differential diagnosis quite extensive. We present the case of a 71-year-old patient with a radiologically described retroperitoneal mass - postoperatively confirmed by pathohistology as a benign schwannoma. The tumor was removed in toto; however, the postoperative course was complicated with symptoms of femoral nerve damage. Although benign in nature (and exceedingly rare to turn malignant) schwannomas are treated surgically as the rate of complete resection without nerve damage is high. Left untreated they gain in mass and can cause significant pain due to displacement of the involved nerve. The significance of this case report is in highlighting the importance of considering schwannomas as a differential diagnosis of retroperitoneal tumors which in turn will lead to a strong strategy for avoiding postoperative complications.Retroperitonealni schwannomi femoralnog živca predstavljaju mali udio primarnih tumora retroperitoneuma. Uzimajući u obzir kako je radiološka dijagnostika u ovom slučaju nespecifična, a diferencijalna dijagnoza primarnih retroperitonealnih tumora široka, ispravnu preoperacijsku dijagnozu ponekad je teško postići. U ovom radu prikazat ćemo slučaj 71-godišnjeg pacijenta sa radiološki opisanim tumorom retroperitoneuma koji je nakon kirurške ekstirpacije patohistološki definiran kao schwannom. Tumor je odstranjen u cijelosti, međutim postoperacijski tijek kompliciran je simptomima jatrogenog oštećenja femoralnog živca. Iako su schwannomi uglavnom dobroćudni tumori uz rijetke slučajeve maligne alteracije, njihovo liječenje prvenstveno je kirurško. Postotak cjelovite resekcije bez oštećenja živca je visok. Neliječeni schwanomi dobivaju na masi te uzrokuju bol pomicanjem i pritiskanjem okolnih struktura. Važnost ovog prikaza leži u naglašavanju femoralnog schwannoma kao diferencijalno-dijagnostičke mogućnosti u razmatranju retroperitonealnih tumora. Na taj način može se stvoriti uspješna strategija sprječavanja postoperacijskih komplikacija

Recurrent retroperitoneal dedifferentiated liposarcoma

Liposarcomas (LPS) are malignant tumors deriving from the adipocytic differentiation process. They are divided into four subtypes of LPS – well-dif ferentiated (WDLPS), dedifferentiated (DDLPS), myxoid (MLPS), and pleomorphic (PLPS). Regarding histological subtype and molecular pathology, tumors have different recurrence rates, radiosensitivity, and chemosensitivity, representing a challenge to every physician involved in their treatment decision. DDLPS commonly appears as a focal outgrowth of a WDLPS lesion

Immunohistochemical expression of 8-oxo-7,8-dihydro-2′-deoxyguanosine in cytoplasm of tumour and adjacent normal mucosa cells in patients with colorectal cancer

BACKGROUND: The aim of this research was to study the levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in tumour tissue samples of colorectal carcinoma based upon immunohistochemical detection and compare those results with patients' outcome. ----- METHODS: Tumour blocks of patients surgically treated for colorectal cancer were evaluated by 8-oxodG immunohistochemical staining. The expression was analysed in 500 tumour cells. The percentage of positive cells, as well as staining intensity, was recorded, and Allred score was calculated. For each patient, data of age, gender, tumour size and location, margin status, histologic grade, tumour stage, lymph node status, vascular invasion, overall survival, and therapy protocols were collected. Tumour grade was divided into two groups as low and high grade. ----- RESULTS: In this study, 146 consecutive patients with primary colorectal carcinoma were included. All data were available for 138 patients, and they were included in this research. There were 83 male and 55 female patients; the median age was 64 years (range 35-87 years). The results showed shorter 5- and 10-year survival in patients with 8-oxodG positive tumour cells (5-year survival, n=138, Mantel-Cox, chi-square 4.116, degree of freedom (df)=1, p<0.05; 10-year survival, n=134, Mantel-Cox, chi-square 4.374, df=1, p<0.05). The results showed a positive correlation between Allred score and high tumour grade (two-tailed Spearman's ρ 0.184; p<0.05), as well as with non-polypoid tumour growth (two-tailed Spearman's ρ 0.198; p<0.05). There was no significant difference of 8-oxodG expression related to age, sex, blood group, size and tumour site, distance from the edge of the resected tumour margin, lymph nodes involvement, and vascular invasion. ----- CONCLUSIONS: In this study, the positive correlation between 8-oxodG presence in the tumour cells, worse clinical outcome, higher tumour grade, and flat morphology was found

COVID-19 i kolorektalni karcinom – toksične poveznice i kako ih prekinuti: KBC Zagreb, iskustvo tercijarnog centra

Colorectal cancer (CRC) is one of the most prevalent oncological diseases globally, taking 3rd place in incidence in the general population. High in mortality, it is also a form of cancer whose outcome is highly dependable on its stage at diagnosis. Therefore, many countries have adopted a more or less successful screening process to ensure early diagnosis and, in turn, higher survival rates and better results overall. The COVID-19 pandemic has altered the established medical routines worldwide, with massively postponing diagnostic procedures and elective surgeries. This study aims to measure the effect the pandemic has had on colorectal cancer treatment in our Institution. Variables such as deferral time from diagnosis to commencement of treatment, lapse of time between different phases of the treatment process, time of presentation (elective versus emergent surgery), the physical status of the patient at the time of surgery (ASA classification) and metastatic index (positive lymph node ratio), were taken into account. We juxtaposed data from patients treated at the Surgical Department of Clinical Hospital Center in Zagreb in 2019 and 2020, the latter being heavily affected by the pandemic. In 2019 and 2020, 347 and 314 patients, respectively, with C18-C20 diagnoses (International Statistical Classification of Diseases and Related Health Problems ICD-10), have been treated at our Hospital. With exclusion criteria applied, the patient count falls to 173 for 2019 and 157 for 2020. These numbers include operated cases with or without an anastomosis formation and with or without neoadjuvant chemotherapy applied. From the analysis we excluded patients with recurrent colorectal tumors, synchronous and metachronous tumors, and patients treated palliatively. Furthermore, colorectal adenomas were also excluded from the study. Our data shows significant difference between observed variables in the two patient groups, attributed to the COVID-19 pandemic. Since there is still no reliable way to predict the duration of this global health crisis, it is imperative to implement strategies to lessen the damaging effect the pandemic has had on favourable oncosurgical treatment outcomes in colorectal cancer patients.Kolorektalni karcinom jedna je od najčešćih onkoloških bolesti u svijetu. Uz visoki mortalitet obilježena je i ovisnošću ishoda liječenja o stadiju bolesti u trenutku dijagnoze. Mnoge su države stoga usvojile više ili manje uspješne programe probira kako bi osigurale ranu dijagnozu, bolje stope preživljenja te generalno optimalnije ishode liječenja. Pandemija COVID-19 u kratkom je roku promijenila temelje medicinske svakodnevice uz nemale odgode dijagnostičkih procedura i elektivnih zahvata. Cilj ovog rada jest procijeniti utjecaj koji je pandemija imala na liječenje kolorektalnog karcinoma u našoj ustanovi. Uspoređivana su dva jednogodišnja razdoblja – 2019. i 2020. od kojih je potonja godina bila značajno pogođena COVID 19 pandemijom. Uspoređivali smo podatke pacijenta liječenih na Zavodu za kirurgiju Kliničkog bolničkog Centra Zagreb, vođenih pod MKB dijagnozama C18-C20. U 2019. godini na našem je Zavodu liječeno 347 pacijena s kolorektalnim karcinom, po primjeni kriterija isključenja ta brojka pada na 173. Bolesnika s operiranim karcinomom koloektuma u 2020. godini u našoj je ustanovi bilo 314, po primjeni kriterija isključenja 157. Praćeni parametri uključivali su vremensku odgodu od incijalne dijagnoze do početka liječenja, vrijeme proteklo između različitih etapa onko kirurškog liječenja, odnos elektivnih i hitnih zahvata, fizičku spremnost pacijenata u vrijeme operacije (ASA klasifikacija) te metastatski index (udio pozitivnih metastatskih limfnih čvorova u dobivenim preparatima). U studiju su uključeni bolesnici neovisno o primjeni neoadjuvantne kemoterapije te neovisno je li intraoepracijski uspostavljen kontinuitet probavne cijevi. Recidivni tumori, metakroni i sinkroni tumori, palijativno liječeni pacijenti, reoperirani te pacijenti operirani uslijed kolorektalnog adenoma nisu uključeni u ovu studiju. Naši podaci pokazuju značajne razlike među praćenim parametrima u dva razdoblja te se iste uvelike pripisuju utjecaju COVID-19 pandemije. Kako su budućnost i trajanje ove medicinske krize još uvijek neizvjesni, potrebno je što prije usvojiti strategije kojima bi se smanjio razorni utjecaj pandemije na ishode liječenja bolesnika sa kolorektalnim karcinomom

Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Cytoreductive Surgery (CS) as Treatment of Peritoneal Carcinomatosis: Preliminary Results in Croatia

The purpose of our study was to evaluate initial results following introduction of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Cytoreductive Surgery (CS). Twenty two patients with intraperitoneal malignancy undergone cytoreductive surgery (CS) and hyperthermic intraoperative chemotherapy (HIPEC) between January of 2007 and January 2010. Nine patients had adenocarcinoma of colorectal origin, 8 patients had ovarian cancer, and 5 had pseudomyxoma peritonei. Inclusion criteria were diagnosis of peritoneal carcinomatosis based on intraoperative assessment during first operative procedure for intraabdominal malignancy or follow-up diagnostic imaging proof. Excluded were patients with known malignant proliferation outside abdomen, liver metastasis and ASA score 4 and higher. All patients with pseudomyxoma peritonei diagnosis are alive, with mean follow-up time 24.8 months (range 15–35). In group of patients with adenocarcinoma from colorectal origin, 3 died, resulting in mean survival time 7.6 months (range 1–16). In group of patients with ovarian cancer, 2 died, resulting in mean survival time 13.8 months (range 0–31). Two patients died in early postoperative period. Most of the patients had some sort of mental disorder. Although HIPEC with CS improves survival, during introduction period higher morbidity and mortality could be expected