Akt-Induced Phosphorylation of N-CoR at Serine 1450 Contributes to Its Misfolded Conformational Dependent Loss (MCDL) in Acute Myeloid Leukemia of the M5 Subtype

10.1371/journal.pone.0070891PLoS ONE88-POLN

Anomalous octahedral distortions in LaFe1-xNixO3

Perovskite-type LaFe1-xNixO3 in the composition range with orthorhombic crystal structure (x = 0.0, 0.1, 0.3 and 0.5) was prepared by the standard solid-state reaction method. The phase formation was checked by synchrotron x-ray diffraction. The structure was refined from the collected x-ray diffraction data using the Reitveld refinement method. The synthesized compositions crystallized mainly in the Pbnm symmetry. The available data in the literature on the structural properties and crystal phase evolution of the solid solution series LaFe1-xNixO3 were also analysed critically. We report an anomalous variation in the octahedral deformations in these compositions. In order to explore the composition-dependent microscopic changes driving these structural distortions, we used the refined structural parameters (cell dimensions and atomic coordinates) from our own results and the literature to calculate and see the effects of composition on several structural distortion parameters in an orthorhombic perovskite. Variation of these parameters strongly suggested that incorporation of Ni in LaFeO3 caused the octahedral deformation to increase. However, octahedral tilting decreased with the addition of Ni in LaFeO3. The obtained change in the orthorhombic distortions was caused by the possible presence of Jahn-Teller Fe4+ cations

Proton, UV, and X-ray Induced Luminescence in Tb3+ Doped LuGd2Ga2Al3O12 Phosphors

The well-known solid-state reaction method is used for the synthesis of Tb doped LuGd2Ga2Al3O12 phosphor. XRD and SEM techniques are used for the phase and structural morphology of the synthesized phosphor. UV, X-ray and proton induced spectroscopy is used to study the luminescence properties. LuGd2Ga2Al3O12:Tb3+ phosphor shows its highest peak in green and blue region. The two major emission peaks correspond to 5D3→7FJ (at 480 to 510 nm, blue region) and 5D4→7FJ (at 535 to 565 nm, green region). Green emission is dominant; therefore, it may be used as an efficient green phosphor. The absorption spectra of the synthesized material matches well with the spectra of light emitting diodes (LEDs); therefore, it may have applications in LEDs. X-ray spectroscopic study suggests that this phosphor may have uses in medical applications, such as X-ray imaging. The synthesized phosphor exhibits 81% efficacy in comparison to the commercial plasma display panel material (Gd2O2S:Tb3+). The Commission Internationale de l’Eclairage (CIE) chromaticity diagram is obtained for this phosphor. The decay time of ms range is measured for the synthesized phosphor

Evaluation of hemodynamically severe coronary stenosis as determined by fractional flow reserve with frequency domain optical coherence tomography measured anatomical parameters

AbstractObjectivesThe main objective of this study is to determine the correlation between fractional flow reserve (FFR)- and frequency domain optical coherence tomography (FD-OCT)-measured lumen parameters, and to determine the diagnostic competence of FD-OCT concerning the identification of severe coronary stenosis.MethodsA total of 41 coronary stenoses in 30 patients were assessed consecutively by quantitative coronary angiography (QCA), FFR, and FD-OCT. Stenoses were labeled severe if FFR≤0.80. The minimal lumen area (MLA), minimal lumen diameter (MLD), and percent lumen area stenosis (%AS) were measured using FD-OCT.ResultsFFR was ≤0.80 in 10 stenoses (24.4%). A poor but significant correlation between FFR and FD-OCT-measured MLA (r2=0.4, p<0.001), MLD (r2=0.28, p<0.001), and %AS (r2=0.13, p=0.02) was found. In the overall group, the diagnostic efficiency of MLA and MLD in identifying significant stenosis was moderate. The area under the curve (AUC) was 0.80 [95% confidence interval (CI): 0.64–0.91] for MLA and 0.76 (95% CI: 0.60–0.88) for MLD. The best cut-off values of FD-OCT-measured lumen parameters to identify stenosis with FFR≤0.80 were 1.62mm2 [specificity 97%, sensitivity 70%, positive predictive value (PPV) 89% and negative predictive value (NPV) 91%] for MLA and 1.23mm (specificity 87%, sensitivity 70%, PPV 64% and NPV 90%) for MLD. The diagnostic efficiency of MLA in identifying significant stenosis in vessels having reference diameter<3mm was high. The AUC was 0.96 (95% CI: 0.83–1.0).ConclusionsThe FFR values and FD-OCT anatomical parameters MLA, MLD were found to be significantly correlated. In the overall group, the FD-OCT-measured MLA and MLD have shown moderate diagnostic efficiency in the functional evaluation of significant stenosis. FD-OCT-measured MLA has high diagnostic efficiency in identifying severe coronary stenosis in vessels having reference diameter <3mm