New Insights into the Surfactant-Assisted Liquid-Phase Exfoliation of Bi2S3 for Electrocatalytic Applications

During water electrolysis, adding an electrocatalyst for the hydrogen evolution reaction (HER) is necessary to reduce the activation barrier and thus enhance the reaction rate. Metal chalcogenide-based 2D nanomaterials have been studied as an alternative to noble metal electrocatalysts because of their interesting electrocatalytic properties and low costs of production. However, the difficulty in improving the catalytic efficiency and industrializing the synthetic methods have become a problem in the potential application of these species in electrocatalysis. Liquid-phase exfoliation (LPE) is a low-cost and scalable technique for lab- and industrial-scale synthesis of 2D-material colloidal inks. In this work, we present, to the best of our knowledge, for the first time a systematic study on the surfactant-assisted LPE of bulk Bi2S3 crystalline powder to produce nanosheets (NSs). Different dispersing agents and LPE conditions have been tested in order to obtain colloidal low-dimensional Bi2S3 NSs in H2O at optimized concentrations. Eventually, colloidally stable layered nano-sized Bi2S3 suspensions can be produced with yields of up to ~12.5%. The thus obtained low-dimensional Bi2S3 is proven to be more active for HER than the bulk starting material, showing an overpotential of only 235 mV and an optimized Tafel slope of 125 mV/dec. Our results provide a facile top-down method to produce nano-sized Bi2S3 through a green approach and demonstrate that this material can have a good potential as electrocatalyst for HER

O-ZONE: affordable stratospheric air dynamic sampling device

The current situation regarding air pollution, global warming and the world approaching the point of no return have led the United Nations to focus on improving the environmental situation through the SDGs [1]. In line with these ambitions, O-ZONE team, was born in 2019 with the clear objective of taking concrete action against climate change [2]. The team's goal is to build a compact, low-cost, and reusable device to sample stratospheric pollutants, at various altitudes and thus provide air quality indications in mid-range areas for monitoring, prevention, and rapid intervention in case of unpredictable events. The O-ZONE team was therefore born as an idea of some students from the Aerospace Engineering course at the same University. The students took part in the REXUS/BEXUS project by Swedish National Space Agency (SNSA), Deutsches Zentrum für Luft- und Raumfahrt (DLR) and European Space Agency (ESA) [3]. As in each of these projects, the team tackled the various steps of space missions but, in this case, with extra constraints. They had to work during the lockdown with various complications due to the pandemic. Although the launch was delayed, the students carried on with their motivation and then launched their device on board the BEXUS 30. The prototype launched in Kiruna - Sweden (at the Esrange base), and which reached an altitude of 27.8 km, is a sampling system for Volatile Organic Compounds (VOCs), such as NOX and SOX, Particulate Matter (PM) and Chlorofluorocarbons (CFCs) responsible for the depletion of the Ozone layer [4]. These types of samplers [2] fill the technological gap in atmospheric analysis; the current state of the art allows air to be monitored only statically from ground stations or by satellite analysis [5], while O-ZONE presents an accessible, easy-to-use and rapid in situ sampling method. This paper describes the technical specifications and design aspects of the device and the experience that has allowed the students to grow as a team, especially in terms of personal skills and the ability to work with concurrent engineering and interdisciplinarity. Finally, the experiment results will be shown

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

New Insights into the Surfactant-Assisted Liquid-Phase Exfoliation of Bi2S3 for Electrocatalytic Applications

During water electrolysis, adding an electrocatalyst for the hydrogen evolution reaction (HER) is necessary to reduce the activation barrier and thus enhance the reaction rate. Metal chalcogenide-based 2D nanomaterials have been studied as an alternative to noble metal electrocatalysts because of their interesting electrocatalytic properties and low costs of production. However, the difficulty in improving the catalytic efficiency and industrializing the synthetic methods have become a problem in the potential application of these species in electrocatalysis. Liquid-phase exfoliation (LPE) is a low-cost and scalable technique for lab- and industrial-scale synthesis of 2D-material colloidal inks. In this work, we present, to the best of our knowledge, for the first time a systematic study on the surfactant-assisted LPE of bulk Bi2S3 crystalline powder to produce nanosheets (NSs). Different dispersing agents and LPE conditions have been tested in order to obtain colloidal lowdimensional Bi2S3 NSs in H2O at optimized concentrations. Eventually, colloidally stable layered nano-sized Bi2S3 suspensions can be produced with yields of up to ~12.5%. The thus obtained low-dimensional Bi2S3 is proven to be more active for HER than the bulk starting material, showing an overpotential of only 235 mV and an optimized Tafel slope of 125 mV/dec. Our results provide a facile top-down method to produce nano-sized Bi2S3 through a green approach and demonstrate that this material can have a good potential as electrocatalyst for HER

Conservative treatment for insertional achilles tendinopathy. platelet-rich plasma and focused shock waves. a retrospective study

BACKGROUND: Insertional Achilles tendinopathy (IAT) represents a serious challenge for both physiatrists and surgeons. Here we analyse the results obtained by two conservative treatments [platelet-rich plasma (PRP) injections and focused extracorporeal shock-wave therapy (ESWT)] in physically active patients with IAT. METHODS: During two consecutive periods, 45 consecutive patients with IAT were treated with 3 sessions of ESWT (2400 impulses at 0.17-0.25 mJ/mm2 per session) (24 cases between September 2011 and July 2013) or with 2 autologous PRP injections over two weeks (21 cases between September 2013 and July 2015). All patients were evaluated at 0, 2-, 4-, 6-month follow-up after therapy. The outcome measures were VISA-A, VAS, Patient Satisfaction. RESULTS: Intra-group analysis showed a significant improvement of VISA-A and VAS scores in both groups at all time-points. No differences between groups were observed for VAS and VISA-A scores at all time-points, excepted for VISA-A at 4-months in favour of ESWT group (P=0.049). Patient satisfaction increased progressively (>70% at 6 months) and with no differences between two groups. CONCLUSION: Both ESWT and PRP therapy are effective and safe. Our study confirms the success of these conservative treatments in Achilles tendinopathy, even in the insertional one

Safety of Rapid Daratumumab Infusion: A Retrospective, Multicenter, Real-Life Analysis on 134 Patients With Multiple Myeloma

BackgroundThe anti-CD38 monoclonal antibody daratumumab is the backbone of most anti-multiple myeloma (MM) regimens. To mitigate the risk of infusion-related reactions (IRRs), intravenous daratumumab administration requires 7 hours for the first infusion and 3.5-4 hours thereafter, thus making daratumumab-containing regimens burdensome for patients and health care resources. Preliminary data suggest that a rapid (90-minute) infusion of daratumumab is safe and does not increase IRRs. The rapid schedule was adopted by our centers since 2019. MethodsWe conducted an observational multi-center, real-life study to assess the safety of rapid daratumumab infusion protocol from the third administration in relapsed MM patients receiving daratumumab alone or in combination with lenalidomide-dexamethasone or bortezomib-dexamethasone. The primary endpoint was the safety of the rapid infusion protocol, particularly in terms of IRRs. ResultsA total of 134 MM patients were enrolled. IRRs occurred in 7 (5%) patients and were mostly mild (6/7 of grade 1-2), with only 1 patient experiencing a grade 3 IRR. Due to the IRRs, 5 (3.7%) patients discontinued the rapid infusions and resumed daratumumab at the standard infusion rate, while 1 patient permanently discontinued daratumumab. In 4/7 patients (57%), IRRs occurred while resuming rapid daratumumab infusions after a temporary interruption (2-4 months). No other adverse event was considered related to the rapid infusion protocol. ConclusionsOur findings confirmed the safety of rapid daratumumab infusions starting from the third administration. In case of prolonged daratumumab interruption, it is advisable to resume infusions at the standard rate (3.5 hours) before switching to the rapid infusion

O-ZONE: affordable stratospheric air dynamic sampling device

The current situation regarding air pollution, global warming and the world approaching the point of no return have led the United Nations to focus on improving the environmental situation through the SDGs [1]. In line with these ambitions, O-ZONE team, was born in 2019 with the clear objective of taking concrete action against climate change [2]. The team's goal is to build a compact, low-cost, and reusable device to sample stratospheric pollutants, at various altitudes and thus provide air quality indications in mid-range areas for monitoring, prevention, and rapid intervention in case of unpredictable events. The O-ZONE team was therefore born as an idea of some students from the Aerospace Engineering course at the same University. The students took part in the REXUS/BEXUS project by Swedish National Space Agency (SNSA), Deutsches Zentrum für Luft- und Raumfahrt (DLR) and European Space Agency (ESA) [3]. As in each of these projects, the team tackled the various steps of space missions but, in this case, with extra constraints. They had to work during the lockdown with various complications due to the pandemic. Although the launch was delayed, the students carried on with their motivation and then launched their device on board the BEXUS 30. The prototype launched in Kiruna - Sweden (at the Esrange base), and which reached an altitude of 27.8 km, is a sampling system for Volatile Organic Compounds (VOCs), such as NOX and SOX, Particulate Matter (PM) and Chlorofluorocarbons (CFCs) responsible for the depletion of the Ozone layer [4]. These types of samplers [2] fill the technological gap in atmospheric analysis; the current state of the art allows air to be monitored only statically from ground stations or by satellite analysis [5], while O-ZONE presents an accessible, easy-to-use and rapid in situ sampling method. This paper describes the technical specifications and design aspects of the device and the experience that has allowed the students to grow as a team, especially in terms of personal skills and the ability to work with concurrent engineering and interdisciplinarity. Finally, the experiment results will be shown

Antimicrobial and antitumor activity of S-methyl dithiocarbazate Schiff base zinc(II) complexes

Schiff bases (SB) obtained from S-methyl dithiocarbazate and aromatic aldehydes: salicylaldehyde (H2L1), o-vanillin (H2L2), pyridoxal (H2L3) and 2,6-diformyl-4-methylphenol (H3L4), and their corresponding Zn(II)-complexes (1-4), are synthesized. All compounds are characterized by elemental analyses, infrared, UV-Vis, nuclear magnetic resonance spectroscopy and mass spectrometry. The structures of H2L2 and [Zn2(L1)2(H2O)(DMF)] (1a) (DMF = dimethylformamide) are solved by single crystal X-ray diffraction. The SB coordinates the metal center through the Ophenolate, Nimine and Sthiolate atoms. The radical scavenging activity is tested using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, with all ligand precursors showing IC50 values ~40 μM. Cytotoxicity studies with several tumor cell lines (PC-3, MCF-7 and Caco-2) as well as a non-tumoral cell line (NHDF) are reported. Interestingly, 1 has relevant and selective antiproliferative effect against Caco-2 cells (IC50 = 9.1 μM). Their antimicrobial activity is evaluated in five bacterial strains (Klebsiella pneumoniae, Acinetobacter baumannii, Listeria monocytogenes, Pseudomonas aeruginosa and Staphylococcus aureus) and two yeast strains (Candida albicans and Candida tropicalis) with some compounds showing bacteriostatic and fungicidal activity. The minimal inhibitory concentration (MIC90) of HnL against Mycobacterium tuberculosis is also reported, with H2L2 and H3L4 showing very high activity (MIC90 < 0.6 μg/mL). The ability of the compounds to bind bovine serum albumin (BSA) and DNA is evaluated for H3L4 and [Zn2(L4)(CH3COO)] (4), both showing high binding constants to BSA (ca. 106 M-1) and ability to bind DNA. Overall, the reported compounds show relevant antitumor and antimicrobial properties, our data indicating they may be promising compounds in several fields of medicinal chemistry.FCT (projects UIDB/00100/2020, UIDP/00100/2020, PTDC/QUI-QAN/32242/2017, UID/Multi/00709/2019, UIDB/50006/2020, UIDB/04378/2020 , SAICTPAC/0019/2015; PD/BD/128320/2017), Programa Operacional Regional de Lisboa (LISBOA-01-0145-FEDER-007317) e FEDER POCI-COMPETE 2020-Operational Programme Competitiveness and Internationalisation (Project POCI-01-0145-FEDER-007491). Yemataw Addis and Israel Tekamo thank the Erasmus Mundus program.info:eu-repo/semantics/publishedVersio

Antimicrobial and antitumor activity of S-methyl dithiocarbazate Schiff base zinc(II) complexes

Schiff bases (SB) obtained from S-methyl dithiocarbazate and aromatic aldehydes: salicylaldehyde (H2L1), o-vanillin (H2L2), pyridoxal (H2L3) and 2,6-diformyl-4-methylphenol (H3L4), and their corresponding Zn(II)-complexes (1-4), are synthesized. All compounds are characterized by elemental analyses, infrared, UV-Vis, nuclear magnetic resonance spectroscopy and mass spectrometry. The structures of H2L2 and [Zn2(L1)2(H2O)(DMF)] (1a) (DMF = dimethylformamide) are solved by single crystal X-ray diffraction. The SB coordinates the metal center through the Ophenolate, Nimine and Sthiolate atoms. The radical scavenging activity is tested using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, with all ligand precursors showing IC50 values ~40 μM. Cytotoxicity studies with several tumor cell lines (PC-3, MCF-7 and Caco-2) as well as a non-tumoral cell line (NHDF) are reported. Interestingly, 1 has relevant and selective antiproliferative effect against Caco-2 cells (IC50 = 9.1 μM). Their antimicrobial activity is evaluated in five bacterial strains (Klebsiella pneumoniae, Acinetobacter baumannii, Listeria monocytogenes, Pseudomonas aeruginosa and Staphylococcus aureus) and two yeast strains (Candida albicans and Candida tropicalis) with some compounds showing bacteriostatic and fungicidal activity. The minimal inhibitory concentration (MIC90) of HnL against Mycobacterium tuberculosis is also reported, with H2L2 and H3L4 showing very high activity (MIC90 < 0.6 μg/mL). The ability of the compounds to bind bovine serum albumin (BSA) and DNA is evaluated for H3L4 and [Zn2(L4)(CH3COO)] (4), both showing high binding constants to BSA (ca. 106 M-1) and ability to bind DNA. Overall, the reported compounds show relevant antitumor and antimicrobial properties, our data indicating they may be promising compounds in several fields of medicinal chemistry.info:eu-repo/semantics/publishedVersio